Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dieter Riddall"'
Autor:
Anastasia Karchevskaya, Tomas C. Bellamy, A. W. Edith Chan, David L. Selwood, Robert G. Keynes, Dieter Riddall, Charmaine Griffiths, John Garthwaite
Publikováno v:
Chemical Biology & Drug Design. 94:1680-1693
During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified. Subsequent tests revealed the compounds act by inhibiting lipid peroxidation, a trigger for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a14da4a9f25f9fa1942b18564f7d156d
https://doi.org/10.1111/cbdd.13572
https://doi.org/10.1111/cbdd.13572
Autor:
Robert G, Keynes, Anastasia, Karchevskaya, Dieter, Riddall, Charmaine H, Griffiths, Tomas C, Bellamy, A W Edith, Chan, David L, Selwood, John, Garthwaite
Publikováno v:
Chemical Biology & Drug Design
During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified. Subsequent tests revealed the compounds act by inhibiting lipid peroxidation, a trigger for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23d611e2a97f55d4b56409aea00e08e7
https://pubmed.ncbi.nlm.nih.gov/31127979
https://pubmed.ncbi.nlm.nih.gov/31127979
Publikováno v:
Journal of Neuroimmune Pharmacology. 10:281-292
Multiple sclerosis (MS) is the major immune-mediated, demyelinating, neurodegenerative disease of the central nervous system. Compounds within cannabis, notably Δ9-tetrahydrocannabinol (Δ9-THC) can limit the inappropriate neurotransmissions that ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8006789bf01e379e1660fd4f171866eb
https://doi.org/10.1007/s11481-014-9575-8
https://doi.org/10.1007/s11481-014-9575-8
Autor:
Masahiro Okuyama, David L. Selwood, Cristina Visintin, Robin Hiley, David Baker, Pui Man Hoi, Abil E. Aliev, Dieter Riddall
Publikováno v:
Organic Letters. 7:1699-1702
[structure: see text] A modular, flexible solid-phase synthetic route for the preparation of biotinylated cross-linking probes of membrane receptors is described. The route utilizes an orthogonal protection strategy employing a Pd[0] cleavable allyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1edc5d1023a0fc8d6342d669e9ab43
https://doi.org/10.1021/ol0502578
https://doi.org/10.1021/ol0502578
Publikováno v:
Molecular Pharmacology. 61:97-104
In the rat isolated optic nerve, nitric oxide (NO) activates soluble guanylyl cyclase (sGC), resulting in a selective accumulation of cGMP in the axons. The axons are also selectively vulnerable to NO toxicity. The experiments initially aimed to dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7d695aaec9010677b7069270ef089a
https://doi.org/10.1124/mol.61.1.97
https://doi.org/10.1124/mol.61.1.97
Autor:
Dieter Riddall, Paul J. Gane, Cristina Garcia Posada, Barrie Lancaster, Lisa Clutterbuck, Cristina Visintin, David L. Selwood, John Garthwaite
Publikováno v:
Journal of medicinal chemistry. 52(9)
We report the discovery of a new class of neuroprotective voltage-dependent sodium channel modulators exemplified by (5-(1-benzyl-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine 11 (CFM1178). The compounds were inhibitors of [(14)C]guanidinium ion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5abd643475de5368fc62edf8b5c0d2
https://pubmed.ncbi.nlm.nih.gov/19341281
https://pubmed.ncbi.nlm.nih.gov/19341281
Autor:
Cristina Garcia Posada, John Garthwaite, David L. Selwood, David Baker, Sarah Al-Izki, Lorcan Browne, Dieter Riddall, Katie Lidster, A. W. Edith Chan, Lisa Clutterbuck
Publikováno v:
Journal of Medicinal Chemistry
A series of imidazol-1-ylethylindazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity. The molecules exhibited displacement of a radiolabeled sodium channel ligand and selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87263e50fc2dd414697bd901e60d9ee
https://doi.org/10.1021/acs.jmedchem.5b00508
https://doi.org/10.1021/acs.jmedchem.5b00508
Publikováno v:
Molecular pharmacology. 69(1)
The effectiveness of several antiepileptic, analgesic, and neuroprotective drugs is attributable to state-dependent inhibition of voltage-gated sodium channels. To help characterize their site and mode of action on sodium channels, a member of the la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::549456908acdd76a44dfdd77a96078a0
https://pubmed.ncbi.nlm.nih.gov/16219909
https://pubmed.ncbi.nlm.nih.gov/16219909
Publikováno v:
ChemInform. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4544c4ba9173ba7bfcc214f91253252
https://doi.org/10.1002/chin.200114297
https://doi.org/10.1002/chin.200114297
Publikováno v:
Journal of medicinal chemistry. 44(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82605f00b5e47c99a23f0352942a17f
https://pubmed.ncbi.nlm.nih.gov/11170622
https://pubmed.ncbi.nlm.nih.gov/11170622