Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dieter Riddall"'
Autor:
Anastasia Karchevskaya, Tomas C. Bellamy, A. W. Edith Chan, David L. Selwood, Robert G. Keynes, Dieter Riddall, Charmaine Griffiths, John Garthwaite
Publikováno v:
Chemical Biology & Drug Design. 94:1680-1693
During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified. Subsequent tests revealed the compounds act by inhibiting lipid peroxidation, a trigger for a
Autor:
Robert G, Keynes, Anastasia, Karchevskaya, Dieter, Riddall, Charmaine H, Griffiths, Tomas C, Bellamy, A W Edith, Chan, David L, Selwood, John, Garthwaite
Publikováno v:
Chemical Biology & Drug Design
During some investigations into the mechanism of nitric oxide consumption by brain preparations, several potent inhibitors of this process were identified. Subsequent tests revealed the compounds act by inhibiting lipid peroxidation, a trigger for a
Publikováno v:
Journal of Neuroimmune Pharmacology. 10:281-292
Multiple sclerosis (MS) is the major immune-mediated, demyelinating, neurodegenerative disease of the central nervous system. Compounds within cannabis, notably Δ9-tetrahydrocannabinol (Δ9-THC) can limit the inappropriate neurotransmissions that ca
Autor:
Masahiro Okuyama, David L. Selwood, Cristina Visintin, Robin Hiley, David Baker, Pui Man Hoi, Abil E. Aliev, Dieter Riddall
Publikováno v:
Organic Letters. 7:1699-1702
[structure: see text] A modular, flexible solid-phase synthetic route for the preparation of biotinylated cross-linking probes of membrane receptors is described. The route utilizes an orthogonal protection strategy employing a Pd[0] cleavable allyl
Publikováno v:
Molecular Pharmacology. 61:97-104
In the rat isolated optic nerve, nitric oxide (NO) activates soluble guanylyl cyclase (sGC), resulting in a selective accumulation of cGMP in the axons. The axons are also selectively vulnerable to NO toxicity. The experiments initially aimed to dete
Autor:
Dieter Riddall, Paul J. Gane, Cristina Garcia Posada, Barrie Lancaster, Lisa Clutterbuck, Cristina Visintin, David L. Selwood, John Garthwaite
Publikováno v:
Journal of medicinal chemistry. 52(9)
We report the discovery of a new class of neuroprotective voltage-dependent sodium channel modulators exemplified by (5-(1-benzyl-1H-indazol-3-yl)-1,2,4-oxadiazol-3-yl)methanamine 11 (CFM1178). The compounds were inhibitors of [(14)C]guanidinium ion
Autor:
Cristina Garcia Posada, John Garthwaite, David L. Selwood, David Baker, Sarah Al-Izki, Lorcan Browne, Dieter Riddall, Katie Lidster, A. W. Edith Chan, Lisa Clutterbuck
Publikováno v:
Journal of Medicinal Chemistry
A series of imidazol-1-ylethylindazole sodium channel ligands were developed and optimized for sodium channel inhibition and in vitro neuroprotective activity. The molecules exhibited displacement of a radiolabeled sodium channel ligand and selectivi
Publikováno v:
Molecular pharmacology. 69(1)
The effectiveness of several antiepileptic, analgesic, and neuroprotective drugs is attributable to state-dependent inhibition of voltage-gated sodium channels. To help characterize their site and mode of action on sodium channels, a member of the la
Publikováno v:
ChemInform. 32
Publikováno v:
Journal of medicinal chemistry. 44(2)