Zobrazeno 1 - 10
of 159
pro vyhledávání: '"Dieter O. Fürst"'
Autor:
Keerthika Lohanadan, Marvin Assent, Anja Linnemann, Julia Schuld, Lukas C. Heukamp, Karsten Krause, Matthias Vorgerd, Jens Reimann, Anne Schänzer, Gregor Kirfel, Dieter O. Fürst, Peter F. M. Van der Ven
Publikováno v:
Cells, Vol 13, Iss 1, p 85 (2023)
Synaptopodin-2 (SYNPO2) is a protein associated with the Z-disc in striated muscle cells. It interacts with α-actinin and filamin C, playing a role in Z-disc maintenance under stress by chaperone-assisted selective autophagy (CASA). In smooth muscle
Externí odkaz:
https://doaj.org/article/d61f3e09ff804350af78d9e5e1d5ffbd
Autor:
Kenichi Kimura, Astrid Ooms, Kathrin Graf-Riesen, Maithreyan Kuppusamy, Andreas Unger, Julia Schuld, Jan Daerr, Achim Lother, Caroline Geisen, Lutz Hein, Satoru Takahashi, Guang Li, Wilhelm Röll, Wilhelm Bloch, Peter F. M. van der Ven, Wolfgang A. Linke, Sean M. Wu, Pitter F. Huesgen, Jörg Höhfeld, Dieter O. Fürst, Bernd K. Fleischmann, Michael Hesse
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
An amino acid exchange (P209L) in the human co-chaperone BAG3 gives rise to severe childhood restrictive cardiomyopathy. Here the authors describe humanized transgenic mouse models which phenocopy the disease and provide insight into the pathogenic m
Externí odkaz:
https://doaj.org/article/6cdac892607d45f6a6225c942b322a42
Autor:
Dominik Sellung, Lorena Heil, Nassam Daya, Frank Jacobsen, Janine Mertens-Rill, Heidi Zhuge, Kristina Döring, Misagh Piran, Hendrik Milting, Andreas Unger, Wolfgang A. Linke, Rudi Kley, Corinna Preusse, Andreas Roos, Dieter O. Fürst, Peter F. M. van der Ven, Matthias Vorgerd
Publikováno v:
Cells, Vol 12, Iss 9, p 1321 (2023)
Myofibrillar myopathies (MFM) are a group of chronic muscle diseases pathophysiologically characterized by accumulation of protein aggregates and structural failure of muscle fibers. A subtype of MFM is caused by heterozygous mutations in the filamin
Externí odkaz:
https://doaj.org/article/20add6ba38594b8185ef55298931e823
Autor:
Youying Mao, Ronen Schneider, Peter F.M. van der Ven, Marvin Assent, Keerthika Lohanadan, Verena Klämbt, Florian Buerger, Thomas M. Kitzler, Konstantin Deutsch, Makiko Nakayama, Amar J. Majmundar, Nina Mann, Tobias Hermle, Ana C. Onuchic-Whitford, Wei Zhou, Nandini Nagarajan Margam, Roy Duncan, Jonathan Marquez, Mustafa Khokha, Hanan M. Fathy, Jameela A. Kari, Sherif El Desoky, Loai A. Eid, Hazem Subhi Awad, Muna Al-Saffar, Shrikant Mane, Richard P. Lifton, Dieter O. Fürst, Shirlee Shril, Friedhelm Hildebrandt
Publikováno v:
Kidney International Reports, Vol 6, Iss 2, Pp 472-483 (2021)
Introduction: Most of the approximately 60 genes that if mutated cause steroid-resistant nephrotic syndrome (SRNS) are highly expressed in the glomerular podocyte, rendering SRNS a “podocytopathy.” Methods: We performed whole-exome sequencing (WE
Externí odkaz:
https://doaj.org/article/dd37eae7f792449e9379ede47e4cb65a
Autor:
Julia Schuld, Zacharias Orfanos, Frédéric Chevessier, Britta Eggers, Lorena Heil, Julian Uszkoreit, Andreas Unger, Gregor Kirfel, Peter F. M. van der Ven, Katrin Marcus, Wolfgang A. Linke, Christoph S. Clemen, Rolf Schröder, Dieter O. Fürst
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Filamin C (FLNc) is mainly expressed in striated muscle cells where it localizes to Z-discs, myotendinous junctions and intercalated discs. Recent studies have revealed numerous mutations in the FLNC gene causing familial and sporadic myopat
Externí odkaz:
https://doaj.org/article/ba3e1050cbf146d9a4a94ff8ab249a1a
Autor:
Andreas Unger, Lisa Beckendorf, Pierre Böhme, Rudolf Kley, Marion von Frieling-Salewsky, Hanns Lochmüller, Rolf Schröder, Dieter O. Fürst, Matthias Vorgerd, Wolfgang A. Linke
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-14 (2017)
Abstract Summary Myopathies encompass a wide variety of acquired and hereditary disorders. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. In this study, we observed incre
Externí odkaz:
https://doaj.org/article/3d5217375fc44a34bd739fc04713fabc
Autor:
Jan eGörtzen, Robert eSchierwagen, Jeanette eBierwolf, Sabine eKlein, Frank Erhard Uschner, Peter F. van der Ven, Dieter O. Fürst, Christian P. Strassburg, Wim eLaleman, Jörg-Matthias ePollok, Jonel eTrebicka
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
Introduction:In liver fibrosis activation of hepatic stellate cells (HSC) comprises phenotypical change into profibrotic and myofibroplastic cells with increased contraction and secretion of extracellular matrix (ECM) proteins. The small GTPase RhoA
Externí odkaz:
https://doaj.org/article/3caf4cf4e3ff47f596df6e57cbff4ad2
Autor:
Andrea Gangfuß, Andreas Hentschel, Lorena Heil, Maria Gonzalez, Anne Schönecker, Christel Depienne, Anna Nishimura, Diana Zengeler, Nicolai Kohlschmidt, Albert Sickmann, Ulrike Schara-Schmidt, Dieter O. Fürst, Peter F.M. van der Ven, Andreas Hahn, Andreas Roos, Anne Schänzer
Publikováno v:
Molecular Genetics and Metabolism. 136:226-237
Popeye domain containing protein 1 (POPDC1) is a highly conserved transmembrane protein essential for striated muscle function and homeostasis. Pathogenic variants in the gene encoding POPDC1 (BVES, Blood vessel epicardial substance) are causative fo
Publikováno v:
Cell and Tissue Research.
Variations in the gene encoding filamin-A-interacting protein 1 (FILIP1) were identified to be associated with a combination of neurological and muscular symptoms. While FILIP1 was shown to regulate motility of brain ventricular zone cells, a process
Autor:
Gerd Bendas, Ulrich Massing, Dieter O. Fürst, Gregor Kirfel, Ralph Graeser, Lenka A. Taylor, Juliane Fritzsche, Martin Schlesinger, Peter Jantscheff
Supplementary Figure 4 from Lysophosphatidylcholine Pretreatment Reduces VLA-4 and P-Selectin–Mediated B16.F10 Melanoma Cell Adhesion In vitro and Inhibits Metastasis-Like Lung Invasion In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f69d327d03e575bced0222a4e83cd4
https://doi.org/10.1158/1535-7163.22482407
https://doi.org/10.1158/1535-7163.22482407