Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Dieter Lutjohann"'
Autor:
Yvonne Benatzy, Megan A. Palmer, Dieter Lütjohann, Rei-Ichi Ohno, Nadja Kampschulte, Nils Helge Schebb, Dominik C. Fuhrmann, Ryan G. Snodgrass, Bernhard Brüne
Publikováno v:
Redox Biology, Vol 72, Iss , Pp 103149- (2024)
Macrophage cholesterol homeostasis is crucial for health and disease and has been linked to the lipid-peroxidizing enzyme arachidonate 15-lipoxygenase type B (ALOX15B), albeit molecular mechanisms remain obscure. We performed global transcriptome and
Externí odkaz:
https://doaj.org/article/b933358c808c402089a6eeabdce94bbe
Autor:
Sarah Schumacher, Laura Klose, Jessica Lambertz, Dieter Lütjohann, Ronald Biemann, Stefanie Kuerten, Lars Fester
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial function plays an important role in the maintenance of male fertility. However, the mechanisms underlying mitochondrial defect-related infertility remain mostly unclear. Here we show that a deficiency of PARL (Parl −/−), a
Externí odkaz:
https://doaj.org/article/bcd2118931454ac8b89d118579038ce3
Autor:
Baravan Al‐Kassou, Lara Al‐Kassou, Thorsten Mahn, Dieter Lütjohann, Jasmin Shamekhi, Nicola Willemsen, Sven Thomas Niepmann, Stephan Baldus, Malte Kelm, Georg Nickenig, Eicke Latz, Sebastian Zimmer
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 3 (2024)
Background Aortic stenosis has pathophysiological similarities with atherosclerosis, including the deposition of cholesterol‐containing lipoproteins. The resulting cholesterol crystals activate the NLRP3 (NOD‐like receptor protein 3) inflammasome
Externí odkaz:
https://doaj.org/article/8256c019cdd446ceb39c342897b4d23c
Autor:
Matteo Spinedi, Christopher Clark, Leonardo Zullo, Anja Kerksiek, Giorgio Pistis, Enrique Castelao, Armin von Gunten, Martin Preisig, Dieter Lütjohann, Julius Popp
Publikováno v:
iScience, Vol 27, Iss 2, Pp 109013- (2024)
Summary: Neurodegenerative, vascular, and dementia diseases are linked to dysregulations in cholesterol metabolism. Dietary plant sterols, or phytosterols, may interfere to neurodegeneration and cognitive decline, and have cholesterol-lowering, anti-
Externí odkaz:
https://doaj.org/article/679ba0983d91415e9526cf37ffdc8e96
Autor:
Silia Ayadi, Silvia Friedrichs, Regis Soulès, Laly Pucheu, Dieter Lütjohann, Sandrine Silvente-Poirot, Marc Poirot, Philippe de Medina
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 12, Pp 100479- (2023)
Oncosterone (6-oxo-cholestane-3β,5α-diol; OCDO) is an oncometabolite and a tumor promoter on estrogen receptor alpha-positive breast cancer (ER(+) BC) and triple-negative breast cancers (TN BC). OCDO is an oxysterol formed in three steps from chole
Externí odkaz:
https://doaj.org/article/ee27e267e8924c2fa1d3759a0eacd722
Autor:
Rebekka Bauer, Sofie Patrizia Meyer, Rebecca Raue, Megan A. Palmer, Vanesa Maria Guerrero Ruiz, Giulia Cardamone, Silvia Rösser, Milou Heffels, Fabian Roesmann, Alexander Wilhelm, Dieter Lütjohann, Kathi Zarnack, Dominik Christian Fuhrmann, Marek Widera, Tobias Schmid, Bernhard Brüne
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Hypoxia contributes to numerous pathophysiological conditions including inflammation-associated diseases. We characterized the impact of hypoxia on the immunometabolic cross-talk between cholesterol and interferon (IFN) responses. Specifically, hypox
Externí odkaz:
https://doaj.org/article/0529142dc6c74d528346fa922d05bbcf
Autor:
Christopher Clark, Mehdi Gholam, Leonardo Zullo, Anja Kerksiek, Enrique Castelao, Armin von Gunten, Martin Preisig, Dieter Lütjohann, Julius Popp
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106740- (2023)
Summary: Dysregulations in cholesterol metabolism are associated with neurodegenerative and vascular pathologies, and dementia. Diet-derived plant sterols (phytosterols) have cholesterol-lowering, anti-inflammatory, and antioxidant properties and may
Externí odkaz:
https://doaj.org/article/0af2c3be12fb4d51ace2f4d09437cedc
Autor:
Sultan Mashnafi, Sabine Baumgartner, Ronald P. Mensink, Desiree Perlee, Lonneke A. van Vught, Dieter Lütjohann, Jogchum Plat
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 126 (2023)
Inflammation is associated with changes in plasma lipids, lipoproteins, and cholesterol efflux capacity (CEC). It is unknown if the changes in lipids and lipoproteins during inflammation are related to changes in cholesterol absorption, synthesis, an
Externí odkaz:
https://doaj.org/article/b1bcaef49814453b9e26fd01feacc5cc
Autor:
Nikita Martens, Melissa Schepers, Na Zhan, Frank Leijten, Gardi Voortman, Assia Tiane, Ben Rombaut, Janne Poisquet, Nienke van de Sande, Anja Kerksiek, Folkert Kuipers, Johan W. Jonker, Hongbing Liu, Dieter Lütjohann, Tim Vanmierlo, Monique T. Mulder
Publikováno v:
Marine Drugs, Vol 19, Iss 4, p 190 (2021)
We recently found that dietary supplementation with the seaweed Sargassum fusiforme, containing the preferential LXRβ-agonist 24(S)-saringosterol, prevented memory decline and reduced amyloid-β (Aβ) deposition in an Alzheimer’s disease (AD) mous
Externí odkaz:
https://doaj.org/article/60ab9b769a024bbc9a50fbfe5a1ccf2c
Autor:
Ryan G. Snodgrass, Ekaterina Zezina, Dmitry Namgaladze, Sahil Gupta, Carlo Angioni, Gerd Geisslinger, Dieter Lütjohann, Bernhard Brüne
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Arachidonate 15-lipoxygenase (ALOX15) and arachidonate 15-lipoxygenase, type B (ALOX15B) catalyze the dioxygenation of polyunsaturated fatty acids and are upregulated in human alternatively activated macrophages (AAMs) induced by Th2 cytokine interle
Externí odkaz:
https://doaj.org/article/d7a10fff9ad64af8bd354fb6ea7e9273