Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Dieter K. Meyer"'
Publikováno v:
Journal of Neurochemistry. 121:597-606
J. Neurochem. (2012) 121, 597–606. Abstract In cultured rat neocortical interneurons, we have studied the effect of long-term application of NMDA or AMPA on the surface density of the NMDA (GluN) receptor subunits GluN1 and GluN2B. Stimulation of C
Publikováno v:
Journal of Biological Chemistry. 281:24955-24969
Dendrite morphogenesis is highly dynamic and characterized by the addition and elongation of processes and also by their selective maintenance, retraction, and elimination. Glutamate can influence these events via N-methyl-d-aspartic acid (NMDA) rece
Autor:
Dieter K. Meyer, Jost Leemhuis, Wolfgang Nörenberg, Steffen Löffler, Kerstin Lindemeyer, Nina Grass
Publikováno v:
Cerebral Cortex. 16:1662-1677
Group I metabotropic glutamate receptors (mGluRIs) can be colocalized with ionotropic glutamate receptors in postsynaptic membranes. We have investigated whether mGluRIs alter the gene transcription induced by N-methyl-D-aspartate (NMDA) and (S)-alph
Autor:
Dieter K. Meyer, Christian Baermann, Ulrike Becker, Catharina Fischer, Isabel Göttsching, Stephanie Boutillier, Gudula Schmidt, Norbert Klugbauer, Jost Leemhuis
Publikováno v:
Journal of Biological Chemistry. 280:25258-25266
Pituitary adenylyl cyclase-activating polypeptide 38 (PACAP38) plays an important role in the proliferation and differentiation of neural cells. In the present study, we have investigated how PACAP38 inhibits the proliferation of cultured neocortical
Autor:
Stephanie Boutillier, Dieter K. Meyer, Bernd Nürnberg, Thomas J. Feuerstein, Klaus Aktories, Jost Leemhuis, Holger Barth, Carsten Brock
Publikováno v:
Journal of Biological Chemistry. 279:585-596
Neurons receive information from other neurons via their dendritic tree. Dendrites and their branches result from alternating outgrowth and retraction. The Rho GTPases Rac and Cdc42 (cell division cycle 42) facilitate the outgrowth of branches, where
Autor:
Gunther Pfeifer, Jost Leemhuis, Dieter K. Meyer, Jörg Schirmer, Holger Barth, Klaus Aktories, Christian Busch
Publikováno v:
Journal of Biological Chemistry. 278:44535-44541
Clostridium difficile toxin B (269 kDa) is one of the causative agents of antibiotic-associated diarrhea and pseudomembranous colitis. Toxin B acts in the cytosol of eukaryotic target cells where it inactivates Rho GTPases by monoglucosylation. The c
Publikováno v:
Journal of Biological Chemistry. 278:32266-32274
Clostridium botulinum C2 toxin is the prototype of the binary actin-ADP-ribosylating toxins and consists of the binding component C2II and the enzyme component C2I. The activated binding component C2IIa forms heptamers, which bind to carbohydrates on
Autor:
Richard Dodel, Olaf Machat, E. Annika Spottke, Dieter K. Meyer, Janeen DuChane, A Smala, Wolfgang H. Oertel, Uwe Siebert, Karin Berger, R Köhne-Volland, Martin Reuther
Publikováno v:
Movement Disorders. 18:898-905
We evaluated the incremental cost-effectiveness of cabergoline compared with levodopa monotherapy in patients with early Parkinson's disease (PD) in the German healthcare system. The study design was based on cost-effectiveness analysis using a Marko
Publikováno v:
Journal of Neurochemistry. 66:1860-1867
In primary culture, type I astroglial cells from neocortex of newborn rats express the proenkephalin gene. The glial cells are not homogeneous but differ in their morphology; i.e., polygonal and process-bearing cells are found. Transcription of the p
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 300:1000-1007
The small GTPase RhoA can retract cell extensions by acting on two Rho kinases (ROCKs). Activated protein kinase A (PKA) inhibits RhoA and induces extensions. The isoquinoline H89 inhibits PKA and thus should prevent the inactivation of RhoA. In kina