Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Dieter Huhn"'
Autor:
Joachim örtel, Stephen Störkel, Dieter Huhn, Karin Kolbe, Detlef Vogel, Stefan Papadileris, Georg Hess, Barbara Seliger, Cornelia Brendel, Andreas Neubauer, Christoph Huber
Publikováno v:
European Journal of Haematology. 57:230-240
The MDM-2 (murine double minute 2) gene codes for a cellular protein that can bind to the p53 tumor suppressor gene product, thereby functioning as a negative regulator of p53. In order to define the role of the MDM-2 gene in the pathogenesis of huma
Autor:
E. Thiel, H. Rodt, B. Netzel, B. Lau, K. Pachmann, P. Dörmer, Gundula Jäger, Dieter Huhn, S. Thierfelder, L. Böning
Publikováno v:
Scandinavian Journal of Haematology. 23:285-292
Cells of the Reh line, originally derived from an ALL of the ‘Non-T, Non-B’ type were cultured in diffusion chambers implanted intraperitoneally into preirradiated CBA mice. At different intervals over a period of 20 d changes in surface characte
Publikováno v:
Scandinavian Journal of Haematology. 26:311-320
136 patients suffering from ALL were subdivided into 5 subtypes (C-ALL, C/T-ALL, pre-T-ALL, B-ALL) according to rosetting tests and using specific antisera directed against membrane antigens. In addition, leukaemic blasts of all patients were investi
Publikováno v:
DMW - Deutsche Medizinische Wochenschrift. 122:268-274
Autor:
Ulrich Mey, Uwe Schlegel, Hendrik Pels, Rudolf Weiss, John Strehl, Ingo G.H. Schmidt-Wolf, Jürgen K. Rockstroh, Dieter Huhn
Publikováno v:
Expert Opinion on Pharmacotherapy. 4:1331-1343
Recently, the median survival of patients with AIDS-related lymphoma has changed significantly. This effect is mainly because of changes in the use of antiviral (highly active antiretroviral therapy; HAART) or chemotherapy regimens. Several novel tre
Autor:
Karl Anton Kreuzer, Philipp le Coutre, Harald Gschaidmeier, Michaela Schwarz, Il-Kang Na, Gerhard Ehninger, Joachim Lupberger, Dieter Huhn, Gökben Baskaynak, Matthias Holdhoff, Christian Schmidt, Witold Prejzner, Uwe Platzbecker
Publikováno v:
American Journal of Hematology. 73:249-255
Previous clinical trials with the tyrosine kinase inhibitor imatinib in chronic-phase Philadelphia chromosome-positive chronic myelogenous leukemia (CML) resulted in 95% of hematologic and 60% major cytogenetic remissions in patients who failed a pre
Autor:
Holger Schulz, Wolfgang-Ulrich Knauf, Michael Hallek, Dieter Huhn, Andreas Engert, Saskia K. Klein, Walter-Erich Aulitzky, Marcel Reiser, Volker Diehl, Manfred Hensel, Ute Rehwald, Axel Hinke, Michael Herold
Publikováno v:
Blood. 100:3115-3120
This multicenter phase 2 trial investigated safety and efficacy of a new immunochemotherapeutic regimen combining rituximab (R) and fludarabine (F) in patients with fludarabine- and anthracycline-naive chronic lymphocytic leukemia (CLL). The rational
Autor:
Bertold Emmerich, Christian Peschel, Anthony D. Ho, Stefanie Srock, Wolfgang Knauf, Christoph von Schilling, Ute Riedel, S. Serke, Martin Wilhelm, Michael Hallek, Dieter Huhn, R. Kuse, Axel Hinke
Publikováno v:
Blood. 98:1326-1331
Rituximab (IDEC-C2B8) is a chimeric antibody that binds to the B-cell surface antigen CD20. Rituximab has significant activity in follicular non-Hodgkin lymphomas. Much less is known about the effects in chronic lymphocytic leukemia (CLL). We have in
Autor:
Andreas E. Albers, Thomas Bieber, Tomislav Dorbic, Stefan Müller, Susanne Kruopis, Andreas Neubauer, Sigrun Niemitz, Tilman Sauerbruch, Beate Trojaneck, Angela Märten, Dieter Huhn, Burghardt Wittig, Jürgen Löffel, Ingo G.H. Schmidt-Wolf, Dimitri Flieger, Silvia Weineck, Heshon Min, Peter Albers
Publikováno v:
Human Gene Therapy. 12:267-278
Therapeutic vaccination of tumor patients with cytokine gene-transfected tumor cells leads to tumor regression in animal models but has so far not resulted in significant clinical benefit. We and others demonstrated that tumor cells transfected to me
Publikováno v:
Cytometry. 46:98-104
Numerous studies have reported that monoclonal antibody (mAb) FMC7 detects an antigen present on only a subset of circulating B lymphocytes. In particular, this mAb may distinguish typical B-cell chronic lymphocytic leukemia (FMC7 negative) from othe