Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Dieter Henrik, Heiland"'
Autor:
Roberto Ferrarese, Kevin Joseph, Geoffroy Andrieux, Ira Verena Haase, Francesca Zanon, Eva Kling, Annalisa Izzo, Eyleen Corrales, Marius Schwabenland, Marco Prinz, Vidhya Madapusi Ravi, Melanie Boerries, Dieter Henrik Heiland, Maria Stella Carro
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-19 (2024)
Abstract Glioma associated macrophages/microglia (GAMs) play an important role in glioblastoma (GBM) progression, due to their massive recruitment to the tumor site and polarization to a tumor promoting phenotype. GAMs secrete a variety of cytokines,
Externí odkaz:
https://doaj.org/article/ec64fa7d721f4c9ab4ed1661a43333cb
Autor:
Dylan Scott Lykke Harwood, Vilde Pedersen, Nicolai Schou Bager, Ane Yde Schmidt, Tobias Overlund Stannius, Aušrinė Areškevičiūtė, Knud Josefsen, Dorte Schou Nørøxe, David Scheie, Hannah Rostalski, Maya Jeje Schuang Lü, Alessio Locallo, Ulrik Lassen, Frederik Otzen Bagger, Joachim Weischenfeldt, Dieter Henrik Heiland, Kristoffer Vitting-Seerup, Signe Regner Michaelsen, Bjarne Winther Kristensen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Glioblastoma remains one of the deadliest brain malignancies. First-line therapy consists of maximal surgical tumor resection, accompanied by chemotherapy and radiotherapy. Malignant cells escape surgical resection by migrating into the surr
Externí odkaz:
https://doaj.org/article/c9a8d9f57fc34c07b292a1cad2634555
Autor:
Jan Kueckelhaus, Simon Frerich, Jasim Kada-Benotmane, Christina Koupourtidou, Jovica Ninkovic, Martin Dichgans, Juergen Beck, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Spatially resolved transcriptomics has revolutionized RNA studies by aligning RNA abundance with tissue structure, enabling direct comparisons between histology and gene expression. Traditional approaches to identifying signature genes often
Externí odkaz:
https://doaj.org/article/5ddb7137c89d4ed887c861114fc3f3b6
Autor:
Yahaya A Yabo, Dieter Henrik Heiland
Publikováno v:
PLoS Biology, Vol 22, Iss 5, p e3002640 (2024)
Glioblastoma, the most aggressive and prevalent form of primary brain tumor, is characterized by rapid growth, diffuse infiltration, and resistance to therapies. Intrinsic heterogeneity and cellular plasticity contribute to its rapid progression unde
Externí odkaz:
https://doaj.org/article/6e25a2af75634933afc145003ed5b73c
Autor:
Jasim Kada Benotmane, Jan Kueckelhaus, Paulina Will, Junyi Zhang, Vidhya M. Ravi, Kevin Joseph, Roman Sankowski, Jürgen Beck, Catalina Lee-Chang, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Spatial resolution of the T cell repertoire is essential for deciphering cancer-associated immune dysfunction. Current spatially resolved transcriptomic technologies are unable to directly annotate T cell receptors (TCR). We present spatiall
Externí odkaz:
https://doaj.org/article/3bbd27aa3be14c8cb9783f3bdb460db0
Autor:
Yuanning Zheng, Francisco Carrillo-Perez, Marija Pizurica, Dieter Henrik Heiland, Olivier Gevaert
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Intra-tumoral heterogeneity and cell-state plasticity are key drivers for the therapeutic resistance of glioblastoma. Here, we investigate the association between spatial cellular organization and glioblastoma prognosis. Leveraging single-ce
Externí odkaz:
https://doaj.org/article/22faf8906d774cada1c4535ae16bc84b
Autor:
Junyi Zhang, Jakob Straehle, Kevin Joseph, Nicolas Neidert, Simon Behringer, Jonathan Göldner, Andreas Vlachos, Marco Prinz, Christian Fung, Jürgen Beck, Oliver Schnell, Dieter Henrik Heiland, Vidhya M. Ravi
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102383- (2023)
Summary: Single-cell RNA-sequencing (scRNA-seq) is becoming a ubiquitous method in profiling the cellular transcriptomes of both malignant and non-malignant cells from the human brain. Here, we present a protocol to isolate viable tumor cells from hu
Externí odkaz:
https://doaj.org/article/473e6440d96c4800a6d5cc303d0106ed
Autor:
Joris Guyon, Ignacio Fernandez‐Moncada, Claire M Larrieu, Cyrielle L Bouchez, Antonio C Pagano Zottola, Johanna Galvis, Tiffanie Chouleur, Audrey Burban, Kevin Joseph, Vidhya M Ravi, Heidi Espedal, Gro Vatne Røsland, Boutaina Daher, Aurélien Barre, Benjamin Dartigues, Slim Karkar, Justine Rudewicz, Irati Romero‐Garmendia, Barbara Klink, Konrad Grützmann, Marie‐Alix Derieppe, Thibaut Molinié, Nina Obad, Céline Léon, Giorgio Seano, Hrvoje Miletic, Dieter Henrik Heiland, Giovanni Marsicano, Macha Nikolski, Rolf Bjerkvig, Andreas Bikfalvi, Thomas Daubon
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp 1-20 (2022)
Abstract Lactate is a central metabolite in brain physiology but also contributes to tumor development. Glioblastoma (GB) is the most common and malignant primary brain tumor in adults, recognized by angiogenic and invasive growth, in addition to its
Externí odkaz:
https://doaj.org/article/ba568585186d48d99efb5ec52859e399
Autor:
Saket Jain, Jonathan W. Rick, Rushikesh S. Joshi, Angad Beniwal, Jordan Spatz, Sabraj Gill, Alexander Chih-Chieh Chang, Nikita Choudhary, Alan T. Nguyen, Sweta Sudhir, Eric J. Chalif, Jia-Shu Chen, Ankush Chandra, Alexander F. Haddad, Harsh Wadhwa, Sumedh S. Shah, Serah Choi, Josie L. Hayes, Lin Wang, Garima Yagnik, Joseph F. Costello, Aaron Diaz, Dieter Henrik Heiland, Manish K. Aghi
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
Cancer-associated fibroblasts (CAFs) were presumed absent in glioblastoma given the lack of brain fibroblasts. Serial trypsinization of glioblastoma specimens yielded cells with CAF morphology and single-cell transcriptomic profiles based on their la
Externí odkaz:
https://doaj.org/article/14cced134af940a49b4d6fa72e0c4da9
Autor:
Vidhya M. Ravi, Nicolas Neidert, Paulina Will, Kevin Joseph, Julian P. Maier, Jan Kückelhaus, Lea Vollmer, Jonathan M. Goeldner, Simon P. Behringer, Florian Scherer, Melanie Boerries, Marie Follo, Tobias Weiss, Daniel Delev, Julius Kernbach, Pamela Franco, Nils Schallner, Christine Dierks, Maria Stella Carro, Ulrich G. Hofmann, Christian Fung, Roman Sankowski, Marco Prinz, Jürgen Beck, Henrike Salié, Bertram Bengsch, Oliver Schnell, Dieter Henrik Heiland
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The tumour microenvironment counteracts immune therapy in Glioblastomas. Authors show here, using spatially resolved and single cell transcriptomics, that dysfunctional T cells are induced by a myeloid cell subset via Interleukin-10 signalling, and i
Externí odkaz:
https://doaj.org/article/c8ede93aa6744a97b9b18e93349c871a