Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Dieter Hamprecht"'
Autor:
Tina Zimmermann, Leo Thomas, Tamara Baader-Pagler, Peter Haebel, Eric Simon, Wolfgang Reindl, Besnik Bajrami, Wolfgang Rist, Ingo Uphues, Daniel J. Drucker, Holger Klein, Rakesh Santhanam, Dieter Hamprecht, Heike Neubauer, Robert Augustin
Publikováno v:
Molecular Metabolism, Vol 66, Iss , Pp 101633- (2022)
Objective: Obesity and its associated comorbidities represent a global health challenge with a need for well-tolerated, effective, and mechanistically diverse pharmaceutical interventions. Oxyntomodulin is a gut peptide that activates the glucagon re
Externí odkaz:
https://doaj.org/article/17b23caf79c94158be502e566134d4c5
Autor:
Alison Findlay, Craig Turner, Heidi Schilter, Mandar Deodhar, Wenbin Zhou, Lara Perryman, Jonathan Foot, Amna Zahoor, Yimin Yao, Ross Hamilton, Mary Brock, Christina Raso, Jessica Stolp, Marie Galati, Dieter Hamprecht, Brett Charlton, Wolfgang Jarolimek
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 11, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/c99b1b5618214a2193bedd33dab46b7d
Autor:
Zhou Wenbin, Mary Brock, Heidi Schilter, Mandar Deodhar, Lara Perryman, Jessica Stolp, Craig Ivan Turner, Dieter Hamprecht, Brett Charlton, Yimin Yao, Wolfgang Jarolimek, Christina Raso, Ross Hamilton, Jonathan Stuart Foot, Marie Galati, Alison D. Findlay, Amna Zahoor
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 11, Pp n/a-n/a (2021)
Clinical and Translational Medicine
Clinical and Translational Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3de0ce4b9cdc8a367fdf85379b88be7
https://doaj.org/article/c99b1b5618214a2193bedd33dab46b7d
https://doaj.org/article/c99b1b5618214a2193bedd33dab46b7d
Publikováno v:
Anti-fibrotic Drug Discovery ISBN: 9781788015103
The hallmark of fibrosis is the accumulation of excessive collagen in tissue as a result of an imbalance between collagen formation and degradation. A key step in collagen formation is its stabilization – and with this, slowing of its degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d159c3af0e387ba4e968c189bceb4887
https://doi.org/10.1039/9781788015783-00145
https://doi.org/10.1039/9781788015783-00145
Autor:
Matteo Di Nicola, Federico Sorana, Cristina Cimarelli, Dieter Hamprecht, Enrico Marcantoni, Roberta Properzi, Riccardo Giovannini, Simone Diomedi
Publikováno v:
Organic & Biomolecular Chemistry. 13:11687-11695
The benzimidazole core is a common moiety in a large number of natural products and pharmacologically active small molecules. The synthesis of novel benzimidazole derivatives remains a main focus in medicinal research. In continuation of the efforts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce475940fb9786d3feed25246253dd43
https://doi.org/10.1039/c5ob01777g
https://doi.org/10.1039/c5ob01777g
Autor:
Holger Wagner, Thomas Trieselmann, Rüdiger Streicher, Dieter Hamprecht, Astrid Volz, Daniela Berta, Paolo Cremonesi, Klaus Fuchs, Gerd Luippold, Herbert Nar, Michael Markert
Publikováno v:
Journal of Medicinal Chemistry. 57:8766-8776
A series of 1,1'-spiro-substituted hexahydrofuroquinoline derivatives exhibiting potent cholesteryl ester transfer protein (CETP) inhibition at reduced lipophilicity was identified. A focused structure-activity relationship (SAR) exploration led to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ff637765eba72695710f87584cc177
https://doi.org/10.1021/jm500431d
https://doi.org/10.1021/jm500431d
Autor:
Enrico Marcantoni, Dieter Hamprecht, Matteo Di Nicola, Cristina Cimarelli, Simone Diomedi, Federico Sorana, Roberta Properzi, Riccardo Giovannini
Publikováno v:
ChemInform. 47
A Ce(III)/Cu(I)-catalytic system mediates the reaction of aryl- and alkylaldehydes (I) and (IV) with o-phenylenediamine (II) to the title compounds in good yields.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87c1af0e78306bbe9e53e2f16e638ce
https://doi.org/10.1002/chin.201616133
https://doi.org/10.1002/chin.201616133
Autor:
Giorgio Bonanomi, Romano Di Fabio, Christian Heidbreder, Luca Tarsi, Silvia Terreni, Adolfo Prandi, Daniele Donati, Dieter Hamprecht, Fabrizio Micheli, Gabriella Gentile
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5491-5494
A new class of azabicyclo[3.1.0]benzenesulfonamides is presented as selective dopamine D3 antagonists together with SAR and selectivity data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d6e5ba0e022a7fe70313d244fa033c
https://doi.org/10.1016/j.bmcl.2010.07.073
https://doi.org/10.1016/j.bmcl.2010.07.073
Autor:
Paolo Celestini, Dieter Hamprecht, Romano Di Fabio, Anna Maria Capelli, Marcella Petrone, Giovanna Tedesco, Federica Damiani, Daniele Donati, Angela Worby, Silvia Terreni, Simone Braggio, Fabrizio Micheli, Stefania Gagliardi, Giorgio Bonanomi, Christian Heidbreder, Gabriella Gentile, Stefano Radaelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:901-907
The synthesis and SAR of a new series of potent and selective dopamine D3 receptor antagonists is reported. The introduction of a tricyclic [h]-fused benzazepine moiety on the recently disclosed scaffold of 1,2,4-triazol-3-yl-thiopropyl-tetrahydroben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6be4c784040906a4df98288c47711e
https://doi.org/10.1016/j.bmcl.2007.12.066
https://doi.org/10.1016/j.bmcl.2007.12.066
Autor:
Albert A. Jaxa-Chamiec, Daniele Donati, Silvia Davalli, Fabrizio Micheli, Marilisa Rinaldi, Giorgio Bonanomi, Giovanna Tedesco, Chiara Gallotti, Martyn D. Wood, Silvia Terreni, Marcella Petrone, Graham J. Riley, Federica Damiani, Dieter Hamprecht, Alessandra Pasquarello, Anna Checchia
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3906-3912
Within the continuous quest for the discovery of novel compounds able to treat anxiety and depression, the generation of a pharmacophore model for 5-HT 2C receptor antagonists and the discovery of a new class of potent and selective 5-HT 2C molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5ba772e4f2408b566e0d2feffaaa17
https://doi.org/10.1016/j.bmcl.2006.05.034
https://doi.org/10.1016/j.bmcl.2006.05.034