Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dieter Haag"'
Autor:
Dieter Haag, Mark A. Findeis, Wesley F. Austin, Nathan O. Fuller, Janos Kovacs, Ruichao Shen, Steffen Phillip Creaser, Gerd Osswald, Jed L. Hubbs, J. L. Ives, Bronk Brian Scott
Publikováno v:
Organic Process Research & Development. 18:676-682
The process development and production of two cycloartenol triterpenoid glycosides on a multikilogram scale are described. The two compounds were used as key intermediates for the synthesis of a γ-secretase modulator and a novel potential therapeuti
Publikováno v:
Organic Process Research & Development. 14:142-151
An entirely new synthesis of the important benzimidazole building block BYK308944 was elaborated using the Stobbe reaction as central element. BYK308944 constitutes an important intermediate for the preparation of 3,6,7,8-tetrahydrochromeno[7,8-d]imi
Publikováno v:
Organic Process Research & Development. 12:1170-1182
A process for the synthesis of the potassium-competitive acid blocker BYK 405879 (8) was established based on the approach used in medicinal chemistry (asymmetric hydrogenation of prochiral ketone 15 and Mitsunobu cyclization of the resulting alcohol
Publikováno v:
Chirality. 12:488-495
L-Rhamnal is readily converted into an allyl 2,3-unsaturated-C-glycopyranoside. The (S) configuration of the αL-anomer defines the stereochemical outcome of the future IMDA reaction, leading to the absolute stereochemistry for the trans-decalin moie
Publikováno v:
Organometallics. 17:398-409
A series of new rhodium(I) complexes [L*Rh(NBD)Cl] (L* = chiral cyclic phosphonite with a fused 1,4-dioxane or cyclobutane ring in the backbone) was synthesized via the corresponding borane−phosphonite adducts. They turned out to be highly active c
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :593-596
The diastereoselectivity of the reduction of 2-substituted cyclohexanones 1–6 with 4-substituted diisobutylaluminium phenoxides a–d has been investigated as a function of temperature. The high-temperature region is found to be dominated by hydrid
Autor:
Dieter Haag, Hans-Dieter Scharf
Publikováno v:
The Journal of Organic Chemistry. 61:6127-6135
The asymmetric intramolecular [2 + 2] photocycloaddition of alpha,beta-enoates was evaluated as a simple access to the novel C(2)-symmetric bisphosphanes 22 and 27 possessing a cyclobutane backbone. A source of different chiral auxiliaries for invest
Autor:
Hans-Dieter Scharf, Dieter Haag
Publikováno v:
ChemInform. 28
The asymmetric intramolecular [2 + 2] photocycloaddition of α,β-enoates was evaluated as a simple access to the novel C2-symmetric bisphosphanes 22 and 27 possessing a cyclobutane backbone. A source of different chiral auxiliaries for investigation
Publikováno v:
ChemInform. 28
Publikováno v:
ChemInform. 30
L-Rhamnal is converted into an hex-2-en-4-ulo C-glycopyranoside in which properly configured diastereomeric centers, asymmetric as well as geometric, are developed in the pendant anomeric substitutent via a Claisen aldol addition, and the resulting p