Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Dieter H. Heiland"'
Autor:
Julia C. Kuehn, Patrick Metzger, Nicolas Neidert, Uta Matysiak, Linda Gräßel, Ulrike Philipp, Sabine Bleul, Thomas Pauli, Julia Falkenstein, Henriette Bertemes, Stepan Cysar, Maria Elena Hess, Anna Verena Frey, Jesús Duque-Afonso, Elisabeth Schorb, Marcia Machein, Jürgen Beck, Oliver Schnell, Nikolas von Bubnoff, Anna L. Illert, Christoph Peters, Tilman Brummer, Marco Prinz, Cornelius Miething, Heiko Becker, Silke Lassmann, Martin Werner, Melanie Börries, Justus Duyster, Dieter H. Heiland, Roman Sankowski, Florian Scherer
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-11 (2024)
Abstract Despite major advances in molecular profiling and classification of primary brain tumors, personalized treatment remains limited for most patients. Here, we explored the feasibility of individual molecular profiling and the efficacy of bioma
Externí odkaz:
https://doaj.org/article/1dc07143d8964d58a48d87e8eab4e848
Autor:
Cathy Pichol-Thievend, Oceane Anezo, Aafrin M. Pettiwala, Guillaume Bourmeau, Remi Montagne, Anne-Marie Lyne, Pierre-Olivier Guichet, Pauline Deshors, Alberto Ballestín, Benjamin Blanchard, Juliette Reveilles, Vidhya M. Ravi, Kevin Joseph, Dieter H. Heiland, Boris Julien, Sophie Leboucher, Laetitia Besse, Patricia Legoix, Florent Dingli, Stephane Liva, Damarys Loew, Elisa Giani, Valentino Ribecco, Charita Furumaya, Laura Marcos-Kovandzic, Konstantin Masliantsev, Thomas Daubon, Lin Wang, Aaron A. Diaz, Oliver Schnell, Jürgen Beck, Nicolas Servant, Lucie Karayan-Tapon, Florence M. G. Cavalli, Giorgio Seano
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Glioblastoma (GBM) is a highly lethal type of cancer. GBM recurrence following chemoradiation is typically attributed to the regrowth of invasive and resistant cells. Therefore, there is a pressing need to gain a deeper understanding of the
Externí odkaz:
https://doaj.org/article/3b619e0cc25442dda280674d2cd28cb1
Autor:
Yahaya A. Yabo, Pilar M. Moreno-Sanchez, Yolanda Pires-Afonso, Tony Kaoma, Bakhtiyor Nosirov, Andrea Scafidi, Luca Ermini, Anuja Lipsa, Anaïs Oudin, Dimitrios Kyriakis, Kamil Grzyb, Suresh K. Poovathingal, Aurélie Poli, Arnaud Muller, Reka Toth, Barbara Klink, Guy Berchem, Christophe Berthold, Frank Hertel, Michel Mittelbronn, Dieter H. Heiland, Alexander Skupin, Petr V. Nazarov, Simone P. Niclou, Alessandro Michelucci, Anna Golebiewska
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-29 (2024)
Abstract Background A major contributing factor to glioblastoma (GBM) development and progression is its ability to evade the immune system by creating an immune-suppressive environment, where GBM-associated myeloid cells, including resident microgli
Externí odkaz:
https://doaj.org/article/f50f4bc53bf740dbaa34414a0760ea24
Autor:
Geoffroy Andrieux, Tonmoy Das, Michaela Griffin, Jakob Straehle, Simon M. L. Paine, Jürgen Beck, Melanie Boerries, Dieter H. Heiland, Stuart J. Smith, Ruman Rahman, Sajib Chakraborty
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-34 (2023)
Abstract Background Spatiotemporal heterogeneity originating from genomic and transcriptional variation was found to contribute to subtype switching in isocitrate dehydrogenase-1 wild-type glioblastoma (GBM) prior to and upon recurrence. Fluorescence
Externí odkaz:
https://doaj.org/article/ddc7f16df4c243c3bdd8102718b49299
Autor:
Thomas Zeyen, Anna-Laura Potthoff, Robert Nemeth, Dieter H. Heiland, Michael C. Burger, Joachim P. Steinbach, Peter Hau, Ghazaleh Tabatabai, Martin Glas, Uwe Schlegel, Oliver Grauer, Dietmar Krex, Oliver Schnell, Roland Goldbrunner, Michael Sabel, Niklas Thon, Daniel Delev, Hans Clusmann, Clemens Seidel, Erdem Güresir, Matthias Schmid, Patrick Schuss, Frank A. Giordano, Alexander Radbruch, Albert Becker, Johannes Weller, Christina Schaub, Hartmut Vatter, Judith Schilling, Frank Winkler, Ulrich Herrlinger, Matthias Schneider
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Glioblastoma is the most frequent and malignant primary brain tumor. Even in the subgroup with O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and favorable response to first-line therapy, survival after relaps
Externí odkaz:
https://doaj.org/article/a07626c82ec8444ab56a35322801927a
Autor:
Anie P. Masilamani, Rana Schulzki, Shuai Yuan, Ira V. Haase, Eva Kling, Franziska Dewes, Geoffroy Andrieux, Melanie Börries, Oliver Schnell, Dieter H. Heiland, Oliver Schilling, Roberto Ferrarese, Maria S. Carro
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104625- (2022)
Summary: Proteolytic cleavage is an important post-translational mechanism to increase protein variability and functionality. In cancer, this process can be deregulated to shut off tumor-suppressive functions. Here, we report that in glioblastoma (GB
Externí odkaz:
https://doaj.org/article/010c74390fea42cf89273a755f0a99a0
Autor:
Dieter H. Heiland, Robin Ohle, Debora Cipriani, Pamela Franco, Daniel Delev, Simon P. Behriger, Elias Kellner, Gergana Petrova, Nicolas Neidert, Irina Mader, Mateo Fariña Nuñez, Horst Urbach, Roman Sankowski, Jürgen Beck, Oliver Schnell
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-9 (2020)
Abstract Background Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favorable clinical outcome
Externí odkaz:
https://doaj.org/article/8fd799d9bbda4b3a99dbe6f84861fdf8
Autor:
Marina Giannaki, Debora E. Ruf, Emilie Pfeifer, Katharina Everaerts, Dieter H. Heiland, Oliver Schnell, Christine R. Rose, Eleni Roussa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8975 (2022)
Glioblastoma multiforme (GBM) is the most common and malignant brain tumour. It is characterised by transcriptionally distinct cell populations. In tumour cells, physiological pH gradients between the intracellular and extracellular compartments are
Externí odkaz:
https://doaj.org/article/c995b58c9dea416d9678779a6a6fbaed
Autor:
Matthias Schneider, Anna-Laura Potthoff, Bernd O. Evert, Marius Dicks, Denise Ehrentraut, Andreas Dolf, Elena N. C. Schmidt, Niklas Schäfer, Valeri Borger, Torsten Pietsch, Mike-Andrew Westhoff, Erdem Güresir, Andreas Waha, Hartmut Vatter, Dieter H. Heiland, Patrick Schuss, Ulrich Herrlinger
Publikováno v:
Pharmaceuticals, Vol 14, Iss 3, p 195 (2021)
Glioblastoma is a malignant brain tumor and one of the most lethal cancers in human. Temozolomide constitutes the standard chemotherapeutic agent, but only shows limited efficacy in glioblastoma patients with unmethylated O-6-methylguanine-DNA methyl
Externí odkaz:
https://doaj.org/article/5e791c578d5b4abab80102e9f8484e03
Autor:
Richard Drexler, Jennifer Göttsche, Thomas Sauvigny, Ulrich Schüller, Robin Khatri, Fabian Hausmann, Sonja Hänzelmann, Tobias B Huber, Stefan Bonn, Dieter H Heiland, Daniel Delev, Varun Venkataramani, Frank Winkler, Johannes Weller, Thomas Zeyen, Ulrich Herrlinger, Jens Gempt, Franz L Ricklefs, Lasse Dührsen
Publikováno v:
Neuro-Oncology. 25:1006-1008
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7043f666e32ee0c994a0047e894ba443
https://doi.org/10.1093/neuonc/noad014
https://doi.org/10.1093/neuonc/noad014