Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Dieter H Wolf"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140363 (2015)
The Saccharomyces cerevisiae heat shock proteins Hsp31, Hsp32, Hsp33 and Hsp34 belong to the DJ-1/ThiJ/PfpI superfamily which includes the human protein DJ-1 (PARK7) as the most prominent member. Mutations in the DJ-1 gene are directly linked to auto
Externí odkaz:
https://doaj.org/article/a8157dc66a2b463b86e36946bb0c5b58
Autor:
Thorsten Pfirrmann, Pablo Villavicencio-Lorini, Abinash K Subudhi, Ruth Menssen, Dieter H Wolf, Thomas Hollemann
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120342 (2015)
In Saccharomyces cerevisiae the Gid-complex functions as an ubiquitin-ligase complex that regulates the metabolic switch between glycolysis and gluconeogenesis. In higher organisms six conserved Gid proteins form the CTLH protein-complex with unknown
Externí odkaz:
https://doaj.org/article/32f1bce80ac44ac7a9bd8d19e17b5f2c
Publikováno v:
FEBS Letters. 592:3286-3294
Glucose consumption via glycolysis and its biosynthesis via gluconeogenesis are central reciprocal pathways controlled by a set of different enzymes. In the yeast Saccharomyces cerevisiae, expression of gluconeogenic enzymes is induced when cells are
Publikováno v:
Annual Review of Biochemistry. 87:751-782
Cells must constantly monitor the integrity of their macromolecular constituents. Proteins are the most versatile class of macromolecules but are sensitive to structural alterations. Misfolded or otherwise aberrant protein structures lead to dysfunct
Publikováno v:
Analytical Biochemistry. 515:14-21
Protein misfolding and protein aggregation are causes of severe diseases as neurodegenerative disorders, diabetes and cancer. Therefore, the cell has to constantly monitor the folding status of its proteome. Chaperones and components of the ubiquitin
Autor:
Dieter H, Wolf, Ruth, Menssen
Publikováno v:
FEBS letters. 592(15)
Precise regulation of cellular processes is essential for life. Regarding proteins, many regulatory mechanisms were explored over the years, such as posttranslational modifications (e.g., phosphorylation), enzyme activation or inhibition by small mol
Autor:
Dieter H. Wolf, Ruth Menssen
Publikováno v:
BIOspektrum. 21:608-611
Protein degradation by the ubiquitin-proteasome system (UPS) is essential for life. Degradation of enzymes and other regulatory proteins like activators or inhibitors is crucial for a multitude of cellular processes. Prominent examples are cell cycle
Publikováno v:
Journal of Biological Chemistry. 290:4677-4687
For the assembly of protein complexes in the cell, the presence of stoichiometric amounts of the respective protein subunits is of utmost importance. A surplus of any of the subunits may trigger unspecific and harmful protein interactions and has to
Publikováno v:
Proceedings of the National Academy of Sciences. 110:15271-15276
Quality control and degradation of misfolded proteins are essential processes of all cells. The endoplasmic reticulum (ER) is the entry site of proteins into the secretory pathway in which protein folding occurs and terminally misfolded proteins are
Autor:
Dieter H. Wolf
'Das Internationale Templerlexikon bietet einen hervorragenden Überblick über die (zeitweise) verworrene Geschichte des Ordens der Tempelritter. Das Lexikon bietet umfassende, spannende und historisch exakte Informationen.'Ein Leser, Amazon Wer war