Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Dieter Hüsken"'
Publikováno v:
ARKIVOC, Vol 2005, Iss 6, Pp 459-469 (2005)
Externí odkaz:
https://doaj.org/article/dfe0551f505f44fab0dcc85c204b77fa
Publikováno v:
CHIMIA, Vol 54, Iss 10 (2000)
The sequence-specific recognition and cleavage of ribonucleic acids (RNA) represents a fundamental challenge. Metal complexes are among the best synthetic catalysts for the cleavage of RNA. Covalent attachment of suitable macrocyclic lanthanide compl
Externí odkaz:
https://doaj.org/article/ad30e4d2b2c94ea09c944f5914575a08
Autor:
Michael Seifert, Christina Schoch, Michael Geffert, Thomas Vogt, Andreas Archut, Dieter Hüsken, Rudolf-Werner Dreier, Thomas Nesseler
In diesem Band: Seite 5: So spannend kann Wissenschaft sein: Mit dem Erfolgsmodell Kinder-Uni erwerben sich Hochschulen und Hochschullehrer viele Sympathien (Michael Seifert) Seite 21: Forschen, feiern, finanzieren - Jubiläen als PR- und Marketingin
Autor:
John F. Cryan, Daniel Hoyer, Rainer Maier, Francois Natt, Susanne Schmid, R Yamamoto, Peter J. Flor, K Mitsukawa, Dieter Hüsken, Kevin H. McAllister, Laura H. Jacobson, Peter H. Kelly, H van der Putten, Deepak R. Thakker, Markus Fendt
Publikováno v:
Molecular Psychiatry. 13:970-979
Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51c73f69abad864b925cb2e73210991
https://doi.org/10.1038/sj.mp.4002073
https://doi.org/10.1038/sj.mp.4002073
Autor:
Rainer Maier, Francois Natt, Matthias M. Müller, Deepak R. Thakker, Daniel Hoyer, John F. Cryan, Herman van der Putten, Dieter Hüsken
Publikováno v:
Proceedings of the National Academy of Sciences. 101:17270-17275
Gene expression analysis implicates an increasing number of novel genes in the brain as potential targets for the treatment of neurological and psychiatric disorders. Frequently, these genes are ubiquitously expressed in the brain and, thus, may cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a4bb1311f1bdaad58a2ef64e477683
https://doi.org/10.1073/pnas.0406214101
https://doi.org/10.1073/pnas.0406214101
Publikováno v:
Bioconjugate Chemistry. 13:945-951
We report here the first successful sequence-specific cleavage of large RNA using artificial ribonucleases. A series of uniformly 2'-methoxyethoxy-modified oligonucleotides bearing a europium complex were investigated as artificial ribonucleases spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3217e7d44138438079ad95e81c0538d9
https://doi.org/10.1021/bc0200024
https://doi.org/10.1021/bc0200024
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids. 20:1181-1185
Fluorescence labelling of nucleic acids is being used for a wide range of biological applications. The performance of these techniques is dependent on fluorochrome labels with a high sensitivity and high resistance to photobleaching. Indo-cyanine dye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe3458451f5ffb2013e0d6ef8fe8da1
https://doi.org/10.1081/ncn-100002515
https://doi.org/10.1081/ncn-100002515
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:929-933
Ndelta-Fmoc protected nucleoamino acids of type I (Base = T, C, A) have been synthesized and employed as building blocks for the construction of novel polyamide based nucleic acid analogues. Homopyrimidine oligomer A binds to complementary RNA with s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4eff7cf62cf64fbca807fdeed784f26
https://doi.org/10.1016/s0960-894x(00)00121-9
https://doi.org/10.1016/s0960-894x(00)00121-9
Publikováno v:
Nucleosides and Nucleotides. 18:1507-1511
Conjugates of lanthanide complexes and oligonucleotides have been shown to bind and to cleave complementary RNA. Modified oligonucleotide building blocks are required to ensure stability of the oligonucleotide against cellular nucleases. For an effic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47cb9cb1927fbf6d73793030526c1c10
https://doi.org/10.1080/07328319908044770
https://doi.org/10.1080/07328319908044770
Publikováno v:
Nucleosides and Nucleotides. 16:1357-1368
A series of lanthanide complexes were synthesized and conjugated to an oligodeoxynucleotide. Sequence-specific cleavage of a complementary RNA by the conjugates was performed and results are discussed in terms of structure of the complexes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e2223529a569f5e4867d71663642a7a
https://doi.org/10.1080/07328319708006187
https://doi.org/10.1080/07328319708006187