Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Dieter Gallemann"'
Autor:
Christian Lüpfert, Martin Dyroff, Oliver von Richter, Dieter Gallemann, Samer El Bawab, Hugues Dolgos, Stefan Hecht, Andreas Johne, Don Jung
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Evofosfamide is a cytotoxic small-molecule prodrug preferentially activated under hypoxic conditions. The cytotoxicity of evofosfamide impacted the generation of in vitro drug-drug interaction (DDI) data, especially in vitro induction results. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1283e1c19491230198345391122408c
https://pubmed.ncbi.nlm.nih.gov/30311747
https://pubmed.ncbi.nlm.nih.gov/30311747
Autor:
Luca Barbero, Hugues Dolgos, Dieter Gallemann, Simona Riva, Mirza Bojić, F. Peter Guengerich, Achim Freisleben
Publikováno v:
Drug Metabolism and Disposition. 42:1438-1446
Cilengitide is a stable cyclic pentapeptide containing an Arg-Gly-Asp motif responsible for selective binding to αVβ3 and αVβ5 integrins. The candidate drug showed unexpected inhibition of cytochrome P450 (P450) 3A4 at high concentrations, that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84636c83e786480b4a2daa63e697ceb5
https://doi.org/10.1124/dmd.114.059295
https://doi.org/10.1124/dmd.114.059295
Autor:
Dominique Perrin, Carl Petersson, Dieter Gallemann, Hugues Dolgos, Tetsuo Yamagata, Ugo Zanelli
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 47(9)
1. We compared direct scaling, regression model equation and the so-called “Poulin et al.” methods to scale clearance (CL) from in vitro intrinsic clearance (CLint) measured in human hepatocytes using two sets of compounds. One reference set comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b3fcc17503d28cc5c7c774176aa50d
https://pubmed.ncbi.nlm.nih.gov/27560606
https://pubmed.ncbi.nlm.nih.gov/27560606
Autor:
Sonja Krösser, Dieter Gallemann, Robert Hermann, Anne Marquet, Peter Wolna, Nicolas Fauchoux, Andreas Johne
Publikováno v:
Biopharmaceutics & Drug Disposition. 33:550-559
The purpose of this mechanistic drug interaction study was to investigate the effects of ketoconazole on the pharmacokinetics of safinamide. Ketoconazole was applied as a potent prototypic inhibitor of cytochrome CYP3A4, to determine the role of CYP3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69d2b679fbf644d9e63da8a0d8f71a9e
https://doi.org/10.1002/bdd.1822
https://doi.org/10.1002/bdd.1822
Autor:
Constance C. Höfer, Achim Freisleben, Hugues Dolgos, Dieter Gallemann, Elmar Wimmer, Markus Fluck, Bernhard Ladstetter
Publikováno v:
Drug Metabolism and Disposition. 38:905-916
In vitro biotransformation studies of sarizotan using human liver microsomes (HLM) showed aromatic and aliphatic monohydroxylation and dealkylation. Recombinant cytochromes P450 (P450) together with P450-selective inhibitors in HLM/hepatocyte culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54cb2c0a0ee88a470683036f22a228c1
https://doi.org/10.1124/dmd.109.029835
https://doi.org/10.1124/dmd.109.029835
Publikováno v:
Clinical Toxicology. 46:551-559
To assess the relationship between blood pressure changes following infusion of antidotal doses of hydroxocobalamin and plasma concentrations of total and free cobalamins-(III).Independent groups of healthy volunteers received single intravenous dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306471ff13c1f90b673d45c94159d35d
https://doi.org/10.1080/15563650701829763
https://doi.org/10.1080/15563650701829763
Autor:
Hugues Dolgos, Friedrich Krätzer, Dieter Gallemann, Tetsuo Yamagata, Markus Fluck, Holger Scheible, Achim Freisleben, Elmar Wimmer
Publikováno v:
Pharmacology Research & Perspectives
Cilengitide is very low permeable (1.0 nm/sec) stable cyclic pentapeptide containing an Arg‐Gly‐Asp motif responsible for selective binding to αvβ3 and αvβ5 integrins administered intravenously (i.v.). In vivo studies in the mouse and Cynomol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264190d295c739b2db9d267aa2eace0e
https://doi.org/10.1002/prp2.217
https://doi.org/10.1002/prp2.217
Autor:
Sonja, Krösser, Anne, Marquet, Dieter, Gallemann, Peter, Wolna, Nicolas, Fauchoux, Robert, Hermann, Andreas, Johne
Publikováno v:
Biopharmaceuticsdrug disposition. 33(9)
The purpose of this mechanistic drug interaction study was to investigate the effects of ketoconazole on the pharmacokinetics of safinamide. Ketoconazole was applied as a potent prototypic inhibitor of cytochrome CYP3A4, to determine the role of CYP3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b195c9f3a272b05edbdcde9340f11a9
https://pubmed.ncbi.nlm.nih.gov/23097240
https://pubmed.ncbi.nlm.nih.gov/23097240
Autor:
Dieter Gallemann, Peter Eyer
Publikováno v:
Biological Chemistry Hoppe-Seyler. 374:51-60
The extent of ferrihemoglobin formation in human erythrocytes by 4-nitrosophenetol and its metabolisation rate strongly depended on the availability of cellular GSH. Ferrihemoglobin formation rate was increased by inhibition of the red cell glutathio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c92635959b93bb462f5989a87ba882
https://doi.org/10.1515/bchm3.1993.374.1-6.51
https://doi.org/10.1515/bchm3.1993.374.1-6.51
Autor:
Dieter Gallemann, Peter Eyer
Publikováno v:
Biological Chemistry Hoppe-Seyler. 371:881-888
During acid precipitation of hemoglobin, hydrogen peroxide is formed. The oxidant is generated from hemoglobin-bound as well as from physically dissolved oxygen, provided divalent hemoglobin-iron is present. The extent of hydrogen peroxide formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a22f61b1fc83fc6018793b3612d5661
https://doi.org/10.1515/bchm3.1990.371.2.881
https://doi.org/10.1515/bchm3.1990.371.2.881