Zobrazeno 1 - 10
of 1 371
pro vyhledávání: '"Dieter E"'
Autor:
Viktor A. Zapol’skii, Isabell Berneburg, Ursula Bilitewski, Melissa Dillenberger, Katja Becker, Stefan Jungwirth, Aditya Shekhar, Bastian Krueger, Dieter E. Kaufmann
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 524-532 (2022)
A series of 26 novel 1-(7-chloroquinolin-4-yl)-4-nitro-1H-pyrazoles bearing a dichloromethyl and an amino or thio moiety at C3 and C5 has been prepared in yields up to 72% from the reaction of 1,1-bisazolyl-, 1-azolyl-1-amino-, and 1-thioperchloro-2-
Externí odkaz:
https://doaj.org/article/ba8e7aa5d9c0460badd51c998a8e57e5
Autor:
Martin Söftje, Thea Weingartz, Rudy Plarre, Mimoza Gjikaj, Jan C. Namyslo, Dieter E. Kaufmann
Publikováno v:
ACS Omega, Vol 6, Iss 49, Pp 33542-33553 (2021)
Externí odkaz:
https://doaj.org/article/31272d7b7f274f8787de82f3f9a799de
Autor:
Viktor A. Zapol’skii, Sandra Kaul, Bianka Karge, Mark Brönstrup, Mimoza Gjikaj, Dieter E. Kaufmann
Publikováno v:
Molecules, Vol 28, Iss 6, p 2479 (2023)
The reaction of mercaptoacetic acid esters with pentachloro-2-nitro-1,3-butadiene provides the appropriate precursors for the synthesis of 2,3,4-trisubstituted benzo[h]quinolines. These heterocycles are easily accessible via a single-step reaction wi
Externí odkaz:
https://doaj.org/article/de935e9722e242e4969013b4e10af1cf
Autor:
Jérôme Granel, Brice Korkmaz, Dalila Nouar, Stefanie A. I. Weiss, Dieter E. Jenne, Roxane Lemoine, Cyrille Hoarau
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Granulomatosis with polyangiitis (GPA) is a rare but serious necrotizing auto-immune vasculitis. GPA is mostly associated with the presence of Anti-Neutrophil Cytoplasmic Antibody (ANCA) targeting proteinase 3 (PR3-ANCA), a serine protease contained
Externí odkaz:
https://doaj.org/article/6b62382e37b34723b8f923559f6d54e8
Publikováno v:
Molecules, Vol 27, Iss 15, p 4875 (2022)
A Knoevenagel based redox-reaction promoted by intramolecular phosphine sources is presented for the first time. The influence of different diketones, aldehydes, bases and acids was investigated. The effects of different substituents were evaluated b
Externí odkaz:
https://doaj.org/article/22a04f0689b5427f908fd3a54e139b94
Autor:
Kristina Haeussler, Isabell Berneburg, Esther Jortzik, Julia Hahn, Mahsa Rahbari, Norma Schulz, Janina Preuss, Viktor A. Zapol’skii, Lars Bode, Anthony B. Pinkerton, Dieter E. Kaufmann, Stefan Rahlfs, Katja Becker
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-19 (2019)
Abstract Background Since malaria parasites highly depend on ribose 5-phosphate for DNA and RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate pathway (PPP) is considered an excellent anti-malarial drug target. In P
Externí odkaz:
https://doaj.org/article/cfe88e3100ec47a894b92d5d4f9bad02
Autor:
Yuan-Ping Pang, Marta Casal Moura, Gwen E. Thompson, Darlene R. Nelson, Amber M. Hummel, Dieter E. Jenne, Daniel Emerling, Wayne Volkmuth, William H. Robinson, Ulrich Specks
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Mutants of a catalytically inactive variant of Proteinase 3 (PR3)—iPR3-Val103 possessing a Ser195Ala mutation relative to wild-type PR3-Val103—offer insights into how autoantigen PR3 interacts with antineutrophil cytoplasmic antibodies (ANCAs) in
Externí odkaz:
https://doaj.org/article/315a254bfbd1410fbcbda94f11de70d8
Autor:
Moritz Leppkes, Christian Maueröder, Sebastian Hirth, Stefanie Nowecki, Claudia Günther, Ulrike Billmeier, Susanne Paulus, Mona Biermann, Luis E. Munoz, Markus Hoffmann, Dane Wildner, Andrew L. Croxford, Ari Waisman, Kerri Mowen, Dieter E. Jenne, Veit Krenn, Julia Mayerle, Markus M. Lerch, Georg Schett, Stefan Wirtz, Markus F. Neurath, Martin Herrmann, Christoph Becker
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby drivi
Externí odkaz:
https://doaj.org/article/8649b3e8245b4fed8b30b9961760de6f
Autor:
Viktor A. Zapol’skii, Ursula Bilitewski, Sören R. Kupiec, Isabell Ramming, Dieter E. Kaufmann
Publikováno v:
Molecules, Vol 25, Iss 12, p 2863 (2020)
Substituted nitrogen heterocycles are structural key units in many important pharmaceuticals. A new synthetic approach towards heterocyclic compounds displaying antibacterial activity against Staphylococcus aureus or cytotoxic activity has been devel
Externí odkaz:
https://doaj.org/article/a98b02a2581c434eb944a88795f8ccc2