Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Dieter Dorsch"'
Autor:
Andreas Blum, Dieter Dorsch, Nina Linde, Susanne Brandstetter, Hans-Peter Buchstaller, Michael Busch, Nina Glaser, Ulrich Grädler, Aaron Ruff, Carl Petersson, Hanno Schieferstein, Eva Sherbetjian, Christina Esdar
Publikováno v:
Journal of Medicinal Chemistry. 66:2386-2395
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71e540463f0bb41b227c72819981e3a5
https://doi.org/10.1021/acs.jmedchem.2c00851
https://doi.org/10.1021/acs.jmedchem.2c00851
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 75K, High responsiveness of c-Met-addicted cell lines to treatment with EMD 1214063 and EMD 1204831. The impact of EMD 1214063 and EMD 1204831 on tumor cell viability (IC50) was tested in vitro, using a panel of tumor cell lines specifical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19326c3f35618f2086e6990b85bcee69
https://doi.org/10.1158/1078-0432.22451541
https://doi.org/10.1158/1078-0432.22451541
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 184K, EMD 1214063 and EMD 1204831 display anti-tumor activity in HGF-dependent and HGF-independent xenograft tumor models. Mice bearing subcutaneous tumors derived from the human gastric Hs746T cell line (A and B) or the glioblastoma U87MG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03592926e46a69b8ef9743e7c67128ac
https://doi.org/10.1158/1078-0432.22451550
https://doi.org/10.1158/1078-0432.22451550
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 255K, Effective inhibition of in vitro tumor cell migration by EMD 1214063 and EMD 1204831. A classical "wound healing" test was performed to assess the impact of EMD 1214063 (A) and EMD 1204831 (B) on tumor cell migration. In brief, H441
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f477947e78a52a3426f6e533a5fb5e63
https://doi.org/10.1158/1078-0432.22451568
https://doi.org/10.1158/1078-0432.22451568
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 53K, Characteristics of the antibodies used in the study. The specificity, isotype, clone number, and commercial source of the antibodies used throughout the study are indicated. All antibodies were used according to the manufacturer's ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167a2577129d987e5e7e4a54a52b7819
https://doi.org/10.1158/1078-0432.22451544.v1
https://doi.org/10.1158/1078-0432.22451544.v1
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
Purpose: The mesenchymal–epithelial transition factor (c-Met) receptor, also known as hepatocyte growth factor receptor (HGFR), controls morphogenesis, a process that is physiologically required for embryonic development and tissue repair. Aberrant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512bb1a709a8f8c2b40276400427ec2d
https://doi.org/10.1158/1078-0432.c.6522216
https://doi.org/10.1158/1078-0432.c.6522216
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 263K, Effects of EMD 1214063 on c-Met phosphorylation and downstream signaling molecules (see Figure 2C). EBC-1 cells were cultured in vitro in control medium (medium + vehicle) (lane 1), or in the presence of increasing concentrations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1325f90de2a065096f938c060a024308
https://doi.org/10.1158/1078-0432.22451571.v1
https://doi.org/10.1158/1078-0432.22451571.v1
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 77K, In vivo tumor growth inhibition by EMD 1214063 and EMD 1204831. The effect of EMD 1214063 and EMD 1204831 on tumor growth (T/C) was evaluated in in vivo xenograft models, using a panel of human tumor cell lines. Both inhibitors were h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db1276d7a369d4924cb438b678643d4
https://doi.org/10.1158/1078-0432.22451538.v1
https://doi.org/10.1158/1078-0432.22451538.v1
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 74K, Effective inhibition of c-Met phosphorylation in U87MG cells. To assess the pharmacodynamic activity of EMD 1214063 and EMD 1204831 in glioblastoma, U87MG glioblastoma cells were exposed for 2 h to either EMD compound. After lysis, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d07a9befe2ce555a1fc10b5f4cb45b5
https://doi.org/10.1158/1078-0432.22451562.v1
https://doi.org/10.1158/1078-0432.22451562.v1
Autor:
Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt
PDF file - 45K, ATP competition studies with EMD 1214063. EMD 1214063 inhibited c-Met phosphorylation in an ATP-competitive fashion. In brief, binding competition of EMD 1214063 and ATP to c-Met was analyzed by a kinase reaction followed by Western b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4391df679377666575d08dead17443d3
https://doi.org/10.1158/1078-0432.22451574
https://doi.org/10.1158/1078-0432.22451574