Výsledky vyhledávání - "Dieter C. Gruenert"

Akademický článek

Seamless Gene Correction in the Human Cystic Fibrosis Transmembrane Conductance Regulator Locus by Vector Replacement and Vector Insertion Events

Autor: Shingo Suzuki, Keisuke Chosa, Cristina Barillà, Michael Yao, Orsetta Zuffardi, Hirofumi Kai, Tsuyoshi Shuto, Mary Ann Suico, Yuet W. Kan, R. Geoffrey Sargent, Dieter C. Gruenert

Publikováno v: Frontiers in Genome Editing, Vol 4 (2022)

Background: Gene correction via homology directed repair (HDR) in patient-derived induced pluripotent stem (iPS) cells for regenerative medicine are becoming a more realistic approach to develop personalized and mutation-specific therapeutic strategi

Externí odkaz: https://doaj.org/article/98771079d2134f55b64cdc7d8d0cd6f4

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Akademický článek

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells

Autor: Shunsuke Kamei, Haruka Fujikawa, Hirofumi Nohara, Keiko Ueno-Shuto, Kasumi Maruta, Ryunosuke Nakashima, Taisei Kawakami, Chizuru Matsumoto, Yuki Sakaguchi, Tomomi Ono, Mary Ann Suico, Richard C. Boucher, Dieter C. Gruenert, Toru Takeo, Naomi Nakagata, Jian-Dong Li, Hirofumi Kai, Tsuyoshi Shuto

Publikováno v: EBioMedicine, Vol 27, Iss C, Pp 304-316 (2018)

Airway mucus hyperproduction and fluid imbalance are important hallmarks of cystic fibrosis (CF), the most common life-shortening genetic disorder in Caucasians. Dysregulated expression and/or function of airway ion transporters, including cystic fib

Externí odkaz: https://doaj.org/article/19a6570ae092400f9570190db666d79f

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Akademický článek

Synergism Between Interleukin (IL)-17 and Toll-like Receptor 2 and 4 Signals to Induce IL-8 Expression in Cystic Fibrosis Airway Epithelial Cells

Autor: Shota Mizunoe, Tsuyoshi Shuto, Shingo Suzuki, Chizuru Matsumoto, Kenji Watanabe, Keiko Ueno-Shuto, Mary Ann Suico, Kouhei Onuki, Dieter C. Gruenert, Hirofumi Kai

Publikováno v: Journal of Pharmacological Sciences, Vol 118, Iss 4, Pp 512-520 (2012)

Cystic fibrosis (CF) is the most common lethal inherited disorder and is caused by mutations in the gene encoding the CF transmembrane regulator (CFTR). The CF lung expresses a profound proinflammatory phenotype that appears to be related to a consti

Externí odkaz: https://doaj.org/article/a743243f34a34a6faede2e4f077ef71b

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Akademický článek

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)

Cystic fibrosis (CF) is a recessive inherited disease associated with multiorgan damage that compromises epithelial and inflammatory cell function. Induced pluripotent stem cells (iPSCs) have significantly advanced the potential of developing a perso

Externí odkaz: https://doaj.org/article/aa7f6c58c90142c2a88dd3a6fd6f2d5f

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NUCLEASE-MEDIATED TARGETED GENETIC CORRECTION

Autor: Dieter C. Gruenert, R. Geoffrey Sargent, Hamid Emamekhoo

Publikováno v: Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology: Principles, Delivery and Pharmacological and Biomedical Applications of Nucleotide-Based Therapies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::439544a817913067978f12e742244b42
https://doi.org/10.1142/9781786346889_0007

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Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation

Autor: Keiko Ueno-Shuto, Jian Dong Li, Yukihiro Tasaki, Yuka Eto, Mary Ann Suico, Shingo Suzuki, Tsuyoshi Shuto, Hirofumi Nohara, Shunsuke Kamei, Taisei Kawakami, Dieter C. Gruenert, Kasumi Maruta, Haruka Fujikawa, Hirofumi Kai, Ryunosuke Nakashima

Publikováno v: Biochemical and biophysical research communications. 509(2)

Cystic fibrosis transmembrane regulator (CFTR) is a cyclic AMP-dependent Cl- channel, and its dysfunction, due to CFTR gene mutations, causes the lethal inherited disorder cystic fibrosis (CF). To date, widespread dysregulation of certain coding gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd72a03e8819097ff84262a46ba971b3
https://pubmed.ncbi.nlm.nih.gov/30598261

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Long Non-coding RNA BGas Regulates the Cystic Fibrosis Transmembrane Conductance Regulator

Autor: Kevin V. Morris, Sheena Saayman, Pad Chivukula, Amanda Ackley, Jon Burdach, Kiyoshi Tachikawa, Dieter C. Gruenert, Matthew Clemson, Marc S. Weinberg

Publikováno v: Molecular Therapy

Cystic fibrosis (CF) is a life-shortening genetic disease. The root cause of CF is heritable recessive mutations that affect the cystic fibrosis transmembrance conductance regulator (CFTR) gene and the subsequent expression and activity of encoded io

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1000f1ab26ea38447e57a17e49b0562e

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Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells

Autor: Jian Dong Li, Naomi Nakagata, Chizuru Matsumoto, Keiko Ueno-Shuto, Ryunosuke Nakashima, Kasumi Maruta, Haruka Fujikawa, Hirofumi Nohara, Toru Takeo, Tomomi Ono, Hirofumi Kai, Richard C. Boucher, Shunsuke Kamei, Tsuyoshi Shuto, Taisei Kawakami, Mary Ann Suico, Dieter C. Gruenert, Yuki Sakaguchi

Publikováno v: EBioMedicine
EBioMedicine, Vol 27, Iss C, Pp 304-316 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274e7c5b346a359b0f0ca965feb012bf

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Reduced surface toll-like receptor-4 expression and absent interferon-γ–inducible protein-10 induction in cystic fibrosis airway cells

Autor: Shashi Chillappagari, Gerrit John, Dieter C. Gruenert, Bruce K. Rubin, Markus O. Henke

Publikováno v: Experimental Lung Research. 37:319-326

As part of the innate and adaptive immune system, airway epithelial cells secrete proinflammatory cytokines after activation of Toll-like receptors (TLRs) by pathogens. Nevertheless, cystic fibrosis (CF) airways are chronically infected with Pseudomo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26e34fcd5b741a42aef294c1f9052a8
https://doi.org/10.3109/01902148.2011.569968

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Cystic fibrosis transmembrane conductance regulator trafficking modulates the barrier function of airway epithelial cell monolayers

Autor: Pierre Lesimple, John W. Hanrahan, Jie Liao, Dieter C. Gruenert, Renaud Robert

Publikováno v: The Journal of Physiology. 588:1195-1209

The cystic fibrosis transmembrane conductance regulator (CFTR) is an integral membrane glycoprotein which functions as an anion channel and influences diverse cellular processes. We studied its role in the development of epithelial tightness by expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62aa2d92ec1c671f7f13dec1a442d9d7
https://doi.org/10.1113/jphysiol.2009.182246

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