Zobrazeno 1 - 10
of 502
pro vyhledávání: '"Dieter, Willbold"'
Autor:
Marlene Pils, Alexandra Dybala, Anja Schaffrath, Fabian Rehn, Janine Kutzsche, Lara Blömeke, Markus Tusche, Pelin Özdüzenciler, Tuyen Bujnicki, Victoria Kraemer-Schulien, Hannes Gramespacher, Maximilian H.T. Schmieschek, Michael T. Barbe, Oezguer A. Onur, Gereon R. Fink, Gültekin Tamgüney, Oliver Bannach, Dieter Willbold
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Misfolding and aggregation of amyloid β (Aβ), along with neurofibrillary tangles consisting of aggregated Tau species, are pathological hallmarks of Alzheimer’s disease (AD) onset and progression. In this study, we hypothesize
Externí odkaz:
https://doaj.org/article/b0b02792593c44ceb0604023450e40a8
Autor:
Laetitia F. Heid, Emil Dandanell Agerschou, Asuka A. Orr, Tatsiana Kupreichyk, Walfried Schneider, Michael M. Wördehoff, Melanie Schwarten, Dieter Willbold, Phanourios Tamamis, Matthias Stoldt, Wolfgang Hoyer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 417-430 (2024)
β-Structure-rich amyloid fibrils are hallmarks of several diseases, including Alzheimer’s (AD), Parkinson’s (PD), and type 2 diabetes (T2D). While amyloid fibrils typically consist of parallel β-sheets, the anti-parallel β-hairpin is a structu
Externí odkaz:
https://doaj.org/article/41def2bd09194e848abe840a29fb7370
Autor:
Fabian Rehn, Victoria Kraemer-Schulien, Tuyen Bujnicki, Oliver Bannach, Diethelm Tschoepe, Bernd Stratmann, Dieter Willbold
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Islet amyloid polypeptide (IAPP) is co-secreted with insulin from pancreatic ß-cells. Its oligomerisation is regarded as disease driving force in type 2 diabetes (T2D) pathology. Up to now, IAPP oligomers have been detected in affected tiss
Externí odkaz:
https://doaj.org/article/66ead056a50842e592fa09df23d4a930
Autor:
Dominik Dluhosch, Lisa Sophie Kersten, Stephan Schott-Verdugo, Claudia Hoppen, Melanie Schwarten, Dieter Willbold, Holger Gohlke, Georg Groth
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Copper chaperones of the ATX1 family are found in a wide range of organisms where these essential soluble carriers strictly control the transport of monovalent copper across the cytoplasm to various targets in diverse cellular compartments t
Externí odkaz:
https://doaj.org/article/2ea017596ca742f9997a535d79d6ed67
Autor:
Alina Üffing, Lisa Gold, Thomas Gensch, Oliver H. Weiergräber, Silke Hoffmann, Dieter Willbold
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
GABARAP, like other ATG8 proteins, is a ubiquitin-like modifier and its C-terminal lipid conjugation enables association with cellular membranes. To prevent interference with the lipidation process, N-terminal fluorescent protein (FP) tagging strateg
Externí odkaz:
https://doaj.org/article/a0335537f8ef46718d27cab83238fdd9
Autor:
Alexandra Viktoria Busley, Óscar Gutiérrez-Gutiérrez, Elke Hammer, Fabian Koitka, Amin Mirzaiebadizi, Martin Steinegger, Constantin Pape, Linda Böhmer, Henning Schroeder, Mandy Kleinsorge, Melanie Engler, Ion Cristian Cirstea, Lothar Gremer, Dieter Willbold, Janine Altmüller, Felix Marbach, Gerd Hasenfuss, Wolfram-Hubertus Zimmermann, Mohammad Reza Ahmadian, Bernd Wollnik, Lukas Cyganek
Publikováno v:
Cell Reports, Vol 43, Iss 7, Pp 114448- (2024)
Summary: Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset hypertrophic cardiomyopathy. In this study, we investigate the mechanistic consequences of a homozygous variant LZTR1L5
Externí odkaz:
https://doaj.org/article/199d047ff2b846ddbbff360254a381ed
Autor:
Giuseppe Sicoli, Daniel Sieme, Kerstin Overkamp, Mahdi Khalil, Robin Backer, Christian Griesinger, Dieter Willbold, Nasrollah Rezaei-Ghaleh
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Liquid-liquid phase separation is the key process underlying formation of membrane-less compartments in cells. A highly dynamic cellular body with rapid component exchange is Cajal body (CB), which supports the extensive compositional dynami
Externí odkaz:
https://doaj.org/article/bcc33a65d54749cc8fbd69a20d52e5f4
Autor:
Lara Blömeke, Fabian Rehn, Victoria Kraemer‐Schulien, Janine Kutzsche, Marlene Pils, Tuyen Bujnicki, Piotr Lewczuk, Johannes Kornhuber, Silka D. Freiesleben, Luisa‐Sophie Schneider, Lukas Preis, Josef Priller, Eike J. Spruth, Slawek Altenstein, Andrea Lohse, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Niels Hansen, Ayda Rostamzadeh, Emrah Düzel, Wenzel Glanz, Enise I. Incesoy, Michaela Butryn, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris‐Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H. Munk, Carolin Sanzenbacher, Annika Spottke, Nina Roy‐Kluth, Michael T. Heneka, Frederic Brosseron, Michael Wagner, Steffen Wolfsgruber, Luca Kleineidam, Melina Stark, Matthias Schmid, Frank Jessen, Oliver Bannach, Dieter Willbold, Oliver Peters
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION Soluble amyloid beta (Aβ) oligomers have been suggested as initiating Aβ related neuropathologic change in Alzheimer's disease (AD) but their quantitative distribution and chronological sequence within the AD continuum remain
Externí odkaz:
https://doaj.org/article/4bb37b34bcf7452db948167c1f2af3cc
Autor:
Anja Schaffrath, Sophia Schleyken, Aline Seger, Hannah Jergas, Pelin Özdüzenciler, Marlene Pils, Lara Blömeke, Anneliese Cousin, Johannes Willbold, Tuyen Bujnicki, Oliver Bannach, Gereon R. Fink, Dieter Willbold, Michael Sommerauer, Michael T. Barbe, Gültekin Tamgüney
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Misfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Thus, α-synuclein aggregates are regarded as a biomarker for the development of diagnostic assays. Quantification of α-synuclein aggregate
Externí odkaz:
https://doaj.org/article/af42695f51354555a4c7b28b085dd396
Autor:
Janine Kutzsche, Sarah Schemmert, Tuyen Bujnicki, Christian Zafiu, Steffen Halbgebauer, Victoria Kraemer-Schulien, Marlene Pils, Lara Blömeke, Julia Post, Andreas Kulawik, Dagmar Jürgens, Wolfgang M. Rossberg, Michael Hümpel, Oliver Bannach, Markus Otto, Joseph A. Araujo, Antje Willuweit, Dieter Willbold
Publikováno v:
Heliyon, Vol 9, Iss 8, Pp e18443- (2023)
Disease-modifying therapies to treat Alzheimer's disease (AD) are of fundamental interest for aging humans, societies, and health care systems. Predictable disease progression in transgenic AD models favors preclinical studies employing a preventive
Externí odkaz:
https://doaj.org/article/92b85f56a79242e6b70799d46bdbe37e