Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Dieter, Langosch"'
Autor:
Nadine T. Werner, Philipp Högel, Gökhan Güner, Walter Stelzer, Manfred Wozny, Marlene Aßfalg, Stefan F. Lichtenthaler, Harald Steiner, Dieter Langosch
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Deuterium/hydrogen exchange shows that conformational flexibility of the hybrid transmembrane domains (TMD) of amyloid precursor proteins plays a role in TMD cleavability by γ-secretase in vitro and in cellulo.
Externí odkaz:
https://doaj.org/article/f8c5876c1e1f44b2bcdc3ca0c114697b
Autor:
Alkmini A. Papadopoulou, Walter Stelzer, Mara Silber, Christine Schlosser, Charlotte Spitz, Martina Haug-Kröper, Tobias Straub, Stephan A. Müller, Stefan F. Lichtenthaler, Claudia Muhle-Goll, Dieter Langosch, Regina Fluhrer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Signal-Peptide Peptidase Like-3 (SPPL3) is an intramembrane cleaving aspartyl protease that causes secretion of extracellular domains from type-II transmembrane proteins. Numerous Golgi-localized glycosidases and glucosyltransferases have be
Externí odkaz:
https://doaj.org/article/9faad70949594762948f92ade4978291
Autor:
Gökhan Güner, Marlene Aßfalg, Kai Zhao, Tobias Dreyer, Shibojyoti Lahiri, Yun Lo, Bianca Ionela Slivinschi, Axel Imhof, Georg Jocher, Laura Strohm, Christian Behrends, Dieter Langosch, Holger Bronger, Christopher Nimsky, Jörg W Bartsch, Stanley R Riddell, Harald Steiner, Stefan F Lichtenthaler
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 10, Pp 1-17 (2022)
Abstract Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also linked to chronic diseases. Despite its physiological and medical importance, the regulation of Fn14 signaling and turnover is only partly unders
Externí odkaz:
https://doaj.org/article/9be7449636e44c638a2a638ecfb8a4fe
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 3230-3242 (2020)
Interactions between their transmembrane domains (TMDs) frequently support the assembly of single-pass membrane proteins to non-covalent complexes. Yet, the TMD-TMD interactome remains largely uncharted. With a view to predicting homotypic TMD-TMD in
Externí odkaz:
https://doaj.org/article/05f84dd9b63343329af2f37a629eb92a
Autor:
Charlotte Spitz, Christine Schlosser, Nadja Guschtschin-Schmidt, Walter Stelzer, Simon Menig, Alexander Götz, Martina Haug-Kröper, Christina Scharnagl, Dieter Langosch, Claudia Muhle-Goll, Regina Fluhrer
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101775- (2020)
Summary: Ectodomain (EC) shedding defines the proteolytic removal of a membrane protein EC and acts as an important molecular switch in signaling and other cellular processes. Using tumor necrosis factor (TNF)α as a model substrate, we identify a no
Externí odkaz:
https://doaj.org/article/c3b63148f6c64088b959a5bd718b3a1c
Autor:
Sara Suna Yücel, Walter Stelzer, Alessandra Lorenzoni, Manfred Wozny, Dieter Langosch, Marius K. Lemberg
Publikováno v:
Cell Reports, Vol 26, Iss 11, Pp 3087-3099.e11 (2019)
Summary: Unspliced XBP1 mRNA encodes XBP1u, the transcriptionally inert variant of the unfolded protein response (UPR) transcription factor XBP1s. XBP1u targets its mRNA-ribosome-nascent-chain-complex to the endoplasmic reticulum (ER) to facilitate U
Externí odkaz:
https://doaj.org/article/60d8072ac21a442c9cfc6d10165dcdc1
Akademický článek
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Autor:
Philipp J. Heckmeier, Dieter Langosch
Publikováno v:
Biochemistry. 60:2457-2462
Green fluorescent protein (GFP) and related fluorescent proteins have multiple applications in cell biology, and elucidating their functions has been at the focus of biophysical research for about three decades. Fluorescent proteins can be bleached b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1263d2650893f6a28c13adea728dfa2f
https://doi.org/10.1021/acs.biochem.1c00248
https://doi.org/10.1021/acs.biochem.1c00248
Autor:
Fabian C. Schmidt, Katja Fitz, Lukas P. Feilen, Masayasu Okochi, Harald Steiner, Dieter Langosch
Publikováno v:
The journal of biological chemistry 299(5), 104626 (2023). doi:10.1016/j.jbc.2023.104626
The γ-secretase complex catalyzes the intramembrane cleavage of C99, a carboxy-terminal fragment of the amyloid precursor protein. Two paralogs of its catalytic subunit presenilin (PS1 and PS2) are expressed which are autocatalytically cleaved into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465afc82bce13c0d2b68e62ee6883d03
https://doi.org/10.1016/j.jbc.2023.104626
https://doi.org/10.1016/j.jbc.2023.104626
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3230-3242 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 3230-3242 (2020)
Highlights • Homotypic TMD interfaces identified by different techniques share strong similarities. • The GxxxG motif is the feature most strongly associated with interfaces. • Other features include conservation, polarity, coevolution, and dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e330fd5430d338ada9a79f5c1e4ecbb7
https://doi.org/10.1016/j.csbj.2020.09.035
https://doi.org/10.1016/j.csbj.2020.09.035