Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Dierk Niessing"'
Autor:
Marcel Proske, Robert Janowski, Sabrina Bacher, Hyun-Seo Kang, Thomas Monecke, Tony Koehler, Saskia Hutten, Jana Tretter, Anna Crois, Lena Molitor, Alejandro Varela-Rial, Roberto Fino, Elisa Donati, Gianni De Fabritiis, Dorothee Dormann, Michael Sattler, Dierk Niessing
Publikováno v:
eLife, Vol 13 (2024)
Mutations in the human PURA gene cause the neurodevelopmental PURA syndrome. In contrast to several other monogenetic disorders, almost all reported mutations in this nucleic acid-binding protein result in the full disease penetrance. In this study,
Externí odkaz:
https://doaj.org/article/13d881e49c7c4676869b2c6bc60d831e
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 483-501 (2022)
The genes hblC, hblD and hblA encode the components Hbl L2, L1 and B of the pore forming enterotoxin haemolysin BL of Bacillus cereus. Two variants of the operon existand the more common one additionally contains hblB downstream of hblCDA. Up to now,
Externí odkaz:
https://doaj.org/article/23b2ec67ee7f44c6ba894fd8b2d76971
Autor:
Michael A Margreiter, Monika Witzenberger, Yasmine Wasser, Elena Davydova, Robert Janowski, Jonas Metz, Pardes Habib, Sabri E.M. Sahnoun, Carina Sobisch, Benedetta Poma, Oscar Palomino-Hernandez, Mirko Wagner, Thomas Carell, N. Jon Shah, Jörg B. Schulz, Dierk Niessing, Aaron Voigt, Giulia Rossetti
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 443-458 (2022)
Polyglutamine (polyQ) diseases are characterized by an expansion of cytosine-adenine-guanine (CAG) trinucleotide repeats encoding for an uninterrupted prolonged polyQ tract. We previously identified TRMT2A as a strong modifier of polyQ-induced toxici
Externí odkaz:
https://doaj.org/article/b64bb5ae313246c5aac74fe4b11f4b6c
Autor:
Luisa Kreft, Aloys Schepers, Miriam Hils, Kyra Swiontek, Andrew Flatley, Robert Janowski, Mohammadali Khan Mirzaei, Michael Dittmar, Neera Chakrapani, Mahesh S. Desai, Stefanie Eyerich, Li Deng, Dierk Niessing, Konrad Fischer, Regina Feederle, Simon Blank, Carsten B. Schmidt-Weber, Christiane Hilger, Tilo Biedermann, Caspar Ohnmacht
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The alpha-Gal epitope (α-Gal) with the determining element galactose-α1,3-galactose can lead to clinically relevant allergic reactions and rejections in xenotransplantation. These immune reactions can develop because humans are devoid of this carbo
Externí odkaz:
https://doaj.org/article/252b4a8f311446508d50f98a1e9b29b0
Autor:
Julia Zinngrebe, Barbara Moepps, Thomas Monecke, Peter Gierschik, Ferdinand Schlichtig, Thomas F E Barth, Gudrun Strauß, Elena Boldrin, Carsten Posovszky, Ansgar Schulz, Ortraud Beringer, Eva Rieser, Eva‐Maria Jacobsen, Myriam Ricarda Lorenz, Klaus Schwarz, Ulrich Pannicke, Henning Walczak, Dierk Niessing, Catharina Schuetz, Pamela Fischer‐Posovszky, Klaus‐Michael Debatin
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 3, Pp n/a-n/a (2022)
Abstract Autoinflammatory diseases are a heterogenous group of disorders defined by fever and systemic inflammation suggesting involvement of genes regulating innate immune responses. Patients with homozygous loss‐of‐function variants in the OTU
Externí odkaz:
https://doaj.org/article/83cf35280c7b412da8856b8b0ae57fcf
Autor:
Tim Schneider, Lee-Hsueh Hung, Masood Aziz, Anna Wilmen, Stephanie Thaum, Jacqueline Wagner, Robert Janowski, Simon Müller, Silke Schreiner, Peter Friedhoff, Stefan Hüttelmaier, Dierk Niessing, Michael Sattler, Andreas Schlundt, Albrecht Bindereif
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Multidomain RNA-binding proteins recognize specific target sequences through mechanisms that are not well understood. Here the authors present an integrated approach to define the RNA-binding specificity and RNP topology and apply it to the analysis
Externí odkaz:
https://doaj.org/article/cc6cce93f90546a49171482eb793687f
Staufen2-mediated RNA recognition and localization requires combinatorial action of multiple domains
Autor:
Simone Heber, Imre Gáspár, Jan-Niklas Tants, Johannes Günther, Sandra M. Fernandez Moya, Robert Janowski, Anne Ephrussi, Michael Sattler, Dierk Niessing
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The Staufen family of RNA-binding proteins are conserved microtubule dependent mRNA transporter factors. Here the authors use biochemical and functional approaches to characterize the RNA-binding properties of mouse Staufen 2 and study the mRNA bindi
Externí odkaz:
https://doaj.org/article/29fa2d6445dc46718928f19f8f73daa7
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
In recent years, genome-wide analyses of patients have resulted in the identification of a number of neurodevelopmental disorders. Several of them are caused by mutations in genes that encode for RNA-binding proteins. One of these genes is PURA, for
Externí odkaz:
https://doaj.org/article/3cf0d96c279d47bdbb000c1536391acb
Autor:
Nina Rehage, Elena Davydova, Christine Conrad, Gesine Behrens, Andreas Maiser, Jenny E. Stehklein, Sven Brenner, Juliane Klein, Aicha Jeridi, Anne Hoffmann, Eunhae Lee, Umberto Dianzani, Rob Willemsen, Regina Feederle, Kristin Reiche, Jörg Hackermüller, Heinrich Leonhardt, Sonia Sharma, Dierk Niessing, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The RNA-binding proteins Roquin-1 and Roquin-2 are essential for immune cell function and postnatal survival in mice. Here, the authors identify NUFIP2 as a cofactor of Roquin; Roquin binds and stabilizes NUFIP2 in cells while NUFIP2 regulates Roquin
Externí odkaz:
https://doaj.org/article/07ebcb03963546dcad91d3831f14ddd0
Autor:
Brigitte Walla, Daniel Bischoff, Robert Janowski, Nikolas von den Eichen, Dierk Niessing, Dirk Weuster-Botz
Publikováno v:
Crystals, Vol 11, Iss 8, p 975 (2021)
Protein crystallization can serve as a purification step in biotechnological processes but is often limited by the non-crystallizability of proteins. Enabling or improving crystallization is mostly achieved by high-throughput screening of crystalliza
Externí odkaz:
https://doaj.org/article/770d49777e2147e592b97a912e3fb421