Hippocampal aggregation signatures of pathogenic UBQLN2 in amyotrophic lateral sclerosis and frontotemporal dementia.

Autor: Thumbadoo KM; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand., Dieriks BV; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland 1010, New Zealand., Murray HC; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland 1010, New Zealand., Swanson MEV; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland 1010, New Zealand., Yoo JH; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.; Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland 1010, New Zealand., Mehrabi NF; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland 1010, New Zealand., Turner C; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland 1010, New Zealand.; Department of Anatomical Pathology, LabPlus, Auckland City Hospital, Auckland 1010, New Zealand., Dragunow M; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.; Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland 1010, New Zealand., Faull RLM; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland 1010, New Zealand., Curtis MA; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland 1010, New Zealand., Siddique T; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.; Department of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA., Shaw CE; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.; UK Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK., Newell KL; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Henden L; Macquarie University Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia., Williams KL; Macquarie University Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia., Nicholson GA; Macquarie University Motor Neuron Disease Research Centre, Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.; Northcott Neuroscience Laboratory, Australian and New Zealand Army Corps (ANZAC) Research Institute, Concord, New South Wales 2139, Australia.; Faculty of Medicine, University of Sydney, Sydney, New South Wales 2050, Australia.; Molecular Medicine Laboratory, Concord Repatriation General Hospital, Concord, New South Wales 2139, Australia., Scotter EL; School of Biological Sciences, University of Auckland, Auckland 1010, New Zealand.; Centre for Brain Research, University of Auckland, Auckland 1010, New Zealand.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Oct 03; Vol. 147 (10), pp. 3547-3561.

Aggregate-prone brain regions in Parkinson's disease are rich in unique N-terminus α-synuclein conformers with high proteolysis susceptibility.

Autor: Wiseman JA; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand. j.wiseman@auckland.ac.nz.; Centre for Brain Research, University of Auckland, Auckland, 1023, New Zealand. j.wiseman@auckland.ac.nz., Murray HC; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, 1023, New Zealand., Faull RLMF; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, 1023, New Zealand., Dragunow M; Centre for Brain Research, University of Auckland, Auckland, 1023, New Zealand.; Department of Pharmacology, University of Auckland, Auckland, 1023, New Zealand., Turner CP; LabPlus, Department of Anatomical Pathology, Te Whatu Ora, Auckland, New Zealand., Dieriks BV; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, 1023, New Zealand., Curtis MA; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand. m.curtis@auckland.ac.nz.; Centre for Brain Research, University of Auckland, Auckland, 1023, New Zealand. m.curtis@auckland.ac.nz.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Jan 02; Vol. 10 (1), pp. 1. Date of Electronic Publication: 2024 Jan 02.

Absolute quantification of neuromelanin in formalin-fixed human brains using absorbance spectrophotometry.

Autor: Chand DA; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Scadeng M; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Mātai Medical Research Institute, Gisborne, New Zealand., Dieriks BV; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand.

Publikováno v: PloS one [PLoS One] 2023 Jul 10; Vol. 18 (7), pp. e0288327. Date of Electronic Publication: 2023 Jul 10 (Print Publication: 2023).

Human pericytes degrade diverse α-synuclein aggregates.

Autor: Dieriks BV; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Highet B; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Alik A; Molecular Imaging Research Center, Francois Jacob Institute, Alternative Energies and Atomic Energy Commission, and Laboratory of Neurodegenerative Diseases, National Center for Scientific Research, Fontenay- Aux-Roses, France., Bellande T; Molecular Imaging Research Center, Francois Jacob Institute, Alternative Energies and Atomic Energy Commission, and Laboratory of Neurodegenerative Diseases, National Center for Scientific Research, Fontenay- Aux-Roses, France., Stevenson TJ; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Low V; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Park TI; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Pharmacology, University of Auckland, Auckland, New Zealand., Correia J; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Auckland City Hospital, Auckland, New Zealand., Schweder P; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Auckland City Hospital, Auckland, New Zealand., Faull RLM; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Melki R; Molecular Imaging Research Center, Francois Jacob Institute, Alternative Energies and Atomic Energy Commission, and Laboratory of Neurodegenerative Diseases, National Center for Scientific Research, Fontenay- Aux-Roses, France., Curtis MA; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Dragunow M; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Pharmacology, University of Auckland, Auckland, New Zealand.

Publikováno v: PloS one [PLoS One] 2022 Nov 18; Vol. 17 (11), pp. e0277658. Date of Electronic Publication: 2022 Nov 18 (Print Publication: 2022).

Lamina-specific immunohistochemical signatures in the olfactory bulb of healthy, Alzheimer's and Parkinson's disease patients.

Autor: Murray HC; Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag, Auckland, 92019, New Zealand. h.murray@auckland.ac.nz.; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA. h.murray@auckland.ac.nz., Johnson K; Bioinformatics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA., Sedlock A; Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA., Highet B; Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag, Auckland, 92019, New Zealand., Dieriks BV; Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag, Auckland, 92019, New Zealand., Anekal PV; Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag, Auckland, 92019, New Zealand.; Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA., Faull RLM; Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag, Auckland, 92019, New Zealand., Curtis MA; Department of Anatomy and Medical Imaging and Centre for Brain Research, Faculty of Medical and Health Science, University of Auckland, Private Bag, Auckland, 92019, New Zealand., Koretsky A; Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA., Maric D; Flow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA. maricd@ninds.nih.gov.

Publikováno v: Communications biology [Commun Biol] 2022 Jan 24; Vol. 5 (1), pp. 88. Date of Electronic Publication: 2022 Jan 24.