Two-dimensional oxygen-diffusion modelling for FLASH proton therapy with pencil beam scanning-Impact of diffusive tissue properties, dose, dose rate and scan patterns.

Autor: Diepeveen MH; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Radiotherapy, Rotterdam, The Netherlands.; Delft University of Technology, Department of Radiation Science and Technology, Delft, The Netherlands., Lathouwers D; Delft University of Technology, Department of Radiation Science and Technology, Delft, The Netherlands.; Holland Proton Therapy Center, Department of Medical Physics and Informatics, Delft, The Netherlands., José Santo R; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Radiotherapy, Rotterdam, The Netherlands.; Holland Proton Therapy Center, Department of Medical Physics and Informatics, Delft, The Netherlands., Hoogeman MS; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Radiotherapy, Rotterdam, The Netherlands.; Delft University of Technology, Department of Radiation Science and Technology, Delft, The Netherlands.; Holland Proton Therapy Center, Department of Medical Physics and Informatics, Delft, The Netherlands., Habraken SJM; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Radiotherapy, Rotterdam, The Netherlands.; Holland Proton Therapy Center, Department of Medical Physics and Informatics, Delft, The Netherlands.; Leiden University Medical Center, Department of Radiotherapy,Leiden, The Netherlands.

Publikováno v: Physics in medicine and biology [Phys Med Biol] 2024 Jul 24; Vol. 69 (15). Date of Electronic Publication: 2024 Jul 24.