The effect of current Schistosoma mansoni infection on the immunogenicity of a candidate TB vaccine, MVA85A, in BCG-vaccinated adolescents: An open-label trial

Autor: Wajja, A, Kizito, D, Nassanga, B, Nalwoga, A, Kabagenyi, J, Kimuda, S, Galiwango, R, Mutonyi, G, Vermaak, S, Satti, I, Verweij, J, Tukahebwa, E, Cose, S, Levin, J, Kaleebu, P, Elliott, AM, McShane, H, Diemert, DJ

Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005440 (2017)
PLoS Neglected Tropical Diseases

Introduction Helminth infection may affect vaccine immunogenicity and efficacy. Adolescents, a target population for tuberculosis booster vaccines, often have a high helminth burden. We investigated effects of Schistosoma mansoni (Sm) on the immunoge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fc743d182d1a4249bc28fff7d9d0c84

Therapeutics for dengue: recommendations for design and conduct of early-phase clinical trials

Autor: Simmons, C, Wolbers, M, Nguyen, MN, Whitehorn, J, Shi, PY, Young, P, Petric, R, Nguyen, VV, Farrar, J, Wills, B, Diemert, DJ

Publikováno v: PLoS Neglected Tropical Diseases, Vol 6, Iss 9, p e1752 (2012)
PLoS Neglected Tropical Diseases

This article describes considerations for the design and conduct of therapeutic trials in dengue. We have recommended a minimum set of clinical and laboratory endpoints in the belief that the field will benefit from a standardized reporting approach.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cece421753b84e2076dc6a794fa2db35
http://ora.ox.ac.uk/objects/uuid:97a3f075-8c6b-4580-a5b0-5e71ed2d4ab1

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Neutralizing Antibody Immune Correlates for a Recombinant Protein Vaccine in the COVAIL Trial.

Autor: Fong Y; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA., Dang L; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Zhang B; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Fintzi J; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Chen S; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Wang J; Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Rouphael NG; Hope Clinic, Emory University, Decatur, Georgia, USA., Branche AR; Vaccine and Treatment Evaluation Unit, University of Rochester, Rochester, New York, USA., Diemert DJ; George Washington Vaccine Research Unit, George Washington University, Washington, District of Columbia, USA., Falsey AR; Vaccine and Treatment Evaluation Unit, University of Rochester, Rochester, New York, USA., Losada C; Hope Clinic, Emory University, Decatur, Georgia, USA., Baden LR; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Frey SE; Center for Vaccine Development, Saint Louis University, Missouri, USA., Whitaker JA; Department of Molecular Virology and Microbiology and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA., Little SJ; Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Kamidani S; Center for Childhood Infections and Vaccines, Children's Healthcare of Atlanta, Georgia, USA.; Department of Pediatrics, Emory University, Atlanta, Georgia, USA., Walter EB; Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA., Novak RM; Project WISH, University of Illinois at Chicago, Chicago, Illinois, USA., Rupp R; Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA., Jackson LA; Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA., Yu C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Magaret CA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Molitor C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Borate B; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA., Babu TM; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA., Kottkamp AC; Vaccine and Treatment Evaluation Unit, Manhattan Research Clinic, New York University Grossman School of Medicine, New York, New York, USA., Luetkemeyer AF; Division of HIV, Infectious Diseases and Global Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, California, USA., Immergluck LC; Clinical Research Center, Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA., Presti RM; Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA., Bäcker M; Vaccine and Treatment Evaluation Unit, Long Island Research Clinic, New York University, Long Island School of Medicine, Mineola, New York, USA., Winokur PL; Department of Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USA., Mahgoub SM; Howard University College of Medicine, Howard University Hospital, Washington, District of Columbia, USA., Goepfert PA; Department of Medicine, University of Alabama at Birmingham, Alabama, USA., Fusco DN; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA., Atmar RL; Department of Molecular Virology and Microbiology and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA., Posavad CM; Infectious Diseases Clinical Research Consortium (IDCRC) Laboratory Operations Unit, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA., Mu J; The Emmes Company, LLC, Rockville, Maryland, USA., Makowski M; The Emmes Company, LLC, Rockville, Maryland, USA., Makhene MK; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Nayak SU; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Roberts PC; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Follmann D; Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Gilbert PB; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.; Department of Biostatistics, School of Public Health, University of Washington, Seattle, Washington, USA.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2024 Sep 26. Date of Electronic Publication: 2024 Sep 26.