Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Diem N Nguyen"'
Autor:
Ahmed R Aoun, Nagaraju Mupparapu, Diem N Nguyen, Tae Ho Kim, Christopher M. Nguyen, Zhengfeiyue Pan, Sherif I. Elshahawi
Publikováno v:
ChemCatChem
Indole is a significant structural moiety and functionalization of the C–H bond in indole-containing molecules expands their chemical space, and modifies their properties and/or activities. Indole prenyltransferases (IPTs) catalyze the direct regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c045822fd12eab4f0a01389f55c3b1
https://doi.org/10.1002/cctc.202300423
https://doi.org/10.1002/cctc.202300423
Autor:
James Z. Deng, Amy Calamari, Samuel L. Graham, Christopher S. Burgey, Eric L. Moore, Craig M. Potteiger, Jixin Wang, Carolyn Segerdell, Daniel V. Paone, James Mulhearn, Cuyue Tang, Diem N. Nguyen, Kerry L. Fillgrove, Shaun R. Stauffer, Michael D. Leitl, Annie Liang, Mark O. Urban, Anthony Ginnetti, Gong Cheng, Anthony W. Shaw, Stefanie A. Kane, Jacqueline Panigel, Christopher A. Salvatore, Sean P. Cook, Juliana Anquandah
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1392-1396
A second-generation small molecule P2X3 receptor antagonist has been developed. The lead optimization strategy to address shortcomings of the first-generation preclinical lead compound is described herein. These studies were directed towards the iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d9a5d8b32ff27b4abbd55923273b1fb
https://doi.org/10.1016/j.bmcl.2018.02.039
https://doi.org/10.1016/j.bmcl.2018.02.039
Autor:
Anthony W. Shaw, Theresa M. Williams, Joseph P. Vacca, Scott D. Mosser, Sean Yu, Christopher A. Salvatore, Craig M. Potteiger, Stefanie A. Kane, Diem N. Nguyen, Christopher S. Burgey, James Z. Deng, Shane Roller, Daniel V. Paone, Harold G. Selnick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2683-2686
In our ongoing efforts to develop CGRP receptor antagonists for the treatment of migraine, we aimed to improve upon telecagepant by targeting a compound with a lower projected clinical dose. Imidazoazepanes were identified as potent caprolactam repla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6e3b8d2d0a8e489087ed560280589f
https://doi.org/10.1016/j.bmcl.2010.12.054
https://doi.org/10.1016/j.bmcl.2010.12.054
Autor:
Samuel L. Graham, James Z. Deng, Diem N. Nguyen, Victor K. Johnston, James C. Hershey, Bradley K. Wong, Christopher A. Salvatore, Cynthia Miller-Stein, Kenneth S. Koblan, Christopher S. Burgey, Scott D. Mosser, Daniel V. Paone, Stefanie A. Kane, Anthony W. Shaw, Theresa M. Williams, Joseph P. Vacca
Publikováno v:
Journal of Medicinal Chemistry. 50:5564-5567
Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Herein we describe optimization of CGRP receptor antagonists based on an earlier lead structure containing a (3R)-amino-(6S)-phenylcaprolactam core. Replaceme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c7168aaf6a57ebfe49a418edf9f59e0
https://doi.org/10.1021/jm070668p
https://doi.org/10.1021/jm070668p
Autor:
Amy G. Quigley, Daniel V. Paone, Melody Mcwherter, Andrew Danziger, Brendan M. Crowley, Mark E. Fraley, Danny Gauvreau, Dan Cui, Karsten Menzel, J. Christopher Culberson, Joseph G. Bruno, Vijay Bhasker G. Reddy, Christopher A. Salvatore, Ian M. Bell, Craig A. Stump, Christopher S. Burgey, Eric L. Moore, Stefanie A. Kane, Amanda L. Kemmerer, Scott D. Mosser, Christine Fandozzi, Diem N. Nguyen, Craig M. Potteiger, Harold G. Selnick, Rebecca B. White
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(21)
In our efforts to develop CGRP receptor antagonists as backups to MK-3207, 2, we employed a scaffold hopping approach to identify a series of novel oxazolidinone-based compounds. The development of a structurally diverse, potent (20, cAMP+HS IC50=0.6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf3aa4e8fe72f15e10763373e410d9a
https://pubmed.ncbi.nlm.nih.gov/26231160
https://pubmed.ncbi.nlm.nih.gov/26231160
Autor:
Beth R. Norton, Ruth Z. Rutledge, Amy G. Quigley, Diem N. Nguyen, Theresa M. Williams, Scott D. Mosser, Christopher S. Burgey, Joseph P. Vacca, James Z. Deng, Samuel L. Graham, Stefanie A. Kane, Ian M. Bell, Christopher A. Salvatore, Craig A. Stump, Kenneth S. Koblan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5052-5056
In our continuing effort to identify CGRP receptor antagonists for the acute treatment of migraine, we have undertaken a study to evaluate alternative 4-substituted piperidines to the lead dihydroquinazolinone 1. In this regard, we have identified th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c577d675ed2b2a43c1e67da3c6f51b
https://doi.org/10.1016/j.bmcl.2006.07.044
https://doi.org/10.1016/j.bmcl.2006.07.044
Autor:
Diem N. Nguyen, Samuel L. Graham, Theresa M. Williams, Scott D. Mosser, Ian M. Bell, Bang-Lin Wan, Kimberly Della Penna, Priya Kunapuli, Stefanie A. Kane, Craig A. Stump, Ruth Z. Rutledge, John F. Fay, Ken S. Koblan, Joseph P. Vacca, C. Blair Zartman, Steven N. Gallicchio, Amy G. Quigley, Christopher A. Salvatore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2595-2598
High-throughput screening of the Merck sample collection identified benzodiazepinone tetralin-spirohydantoin 1 as a CGRP receptor antagonist with micromolar activity. Comparing the structure of 1 with those of earlier peptide-based antagonists such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6628f20dd0bcf6f444b0f155b9357fdc
https://doi.org/10.1016/j.bmcl.2006.02.051
https://doi.org/10.1016/j.bmcl.2006.02.051
Autor:
Diem N. Nguyen, Mary Beth O'Connell
Publikováno v:
Pharmacotherapy. 22:1047-1054
Study Objective. To quantify Asian and Asian-American college students' knowledge of osteoporosis and preventive health behaviors. Design. Sixty-four-question survey. Setting. University of Minnesota. Subjects. One hundred sixty-eight male and female
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3736d345ec4da80ce9fcbde31acac57
https://doi.org/10.1592/phco.22.12.1047.33608
https://doi.org/10.1592/phco.22.12.1047.33608
Autor:
Carolyn A. Buser, Christine Fernandes, Diem N. Nguyen, Michelle Ellis-Hutchings, Robert B. Lobell, Ronald G. Robinson, Craig A. Stump, Hans E. Huber, Eileen S. Walsh, Theresa M. Williams, Joseph P. Davide
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1269-1273
Compound 1 has been shown to be a dual prenylation inhibitor with FPTase (IC50=2 nM) and GGPTase-I (IC50=95 nM). Analogues of 1, which replaced the cyanophenyl group with various biaryls, led to the discovery of highly potent dual FPTase/GGPTase-I in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::966e10e6069a40a99a4fd80aa9d2b26a
https://doi.org/10.1016/s0960-894x(02)00154-3
https://doi.org/10.1016/s0960-894x(02)00154-3
Autor:
Diem N. Nguyen, et al. et al.
Publikováno v:
ChemInform. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b3ea169d8eb948fae9e82371e08b016
https://doi.org/10.1002/chin.200234176
https://doi.org/10.1002/chin.200234176