Development and Validation of an Integrative Risk Score for Future Risk of Crohn’s Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study

Autor: Lee, Sun-Ho, Turpin, Williams, Espin-Garcia, Osvaldo, Xu, Wei, Leibovitzh, Haim, Xue, Mingyue, Raygoza Garay, Juan Antonio, Graña-Miraglia, Lucía, Smith, Michelle I., Goethel, Ashleigh, Madsen, Karen L., Avni-Biron, Irit, Dotan, Iris, Weiss, Batia, Panaccione, Remo, Huynh, Hien, Jacobson, Kevan, Aumais, Guy, Mack, David, Griffiths, Anne M., Steinhart, A. Hillary, Silverberg, Mark S., Turner, Dan, Bernstein, Charles N., Feagan, Brian G., Moayyedi, Paul, Paterson, Andrew, Guttman, David S., Abreu, Maria, Beck, Paul, Dieleman, Leo, Kaplan, Gilaad, Krause, Denis O., Marshall, John, Ropeleski, Mark, Seidman, Ernest, Snapper, Scott, Stadnyk, Andy, Surette, Michael, Walters, Thomas, Vallance, Bruce, Bitton, Alain, Cino, Maria, Critch, Jeff, Denson, Lee, Deslandres, Colette, El-Matary, Wael, Herfarth, Hans, Higgins, Peter, Hyams, Jeff, McGrath, Jerry, Otley, Anthony, Croitoru, Kenneth

Publikováno v: In Gastroenterology August 2024

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Early Life Exposure to Parental Crohn's Disease Is Associated With Offspring's Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn's Disease.

Autor: Lee SH; Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address: Sun-Ho.Lee@sinaihealth.ca., Bushra M; Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada., Qiu L; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada., Griffiths AM; Inflammatory Bowel Disease Centre, The Hospital for Sick Children, Temerty Faculty of Medicine, Department of Paediatrics, University of Toronto, Toronto, Ontario, Canada., Turpin W; Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada., Croitoru K; Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto; Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada. Electronic address: Ken.Croitoru@sinaihealth.ca., Abreu M, Beck P, Bernstein C, Croitoru K, Dieleman L, Feagan B, Griffiths A, Guttman D, Jacobson K, Kaplan G, Krause DO, Madsen K, Marshall J, Moayyedi P, Ropeleski M, Seidman E, Silverberg M, Snapper S, Stadnyk A, Steinhart AH, Surette M, Turner D, Walters T, Vallance B, Aumais G, Bitton A, Cino M, Critch J, Denson L, Deslandres C, El-Matary W, Herfarth H, Higgins P, Huynh HQ, Hyams J, Mack D, McGrath J, Otley A, Panancionne R, Abreu M, Aumais G, Baldassano R, Bernstein C, Cino M, Denson L, Deslandres C, El-Matary W, Griffiths AM, Hedin C, Herfarth H, Higgins P, Hussey S, Huynh HQ, Jacobson K, Keljo D, Kevans D, Lees C, Mack D, Marshall J, McGrath J, Murthy S, Otley A, Panaccione R, Parekh N, Plamondon S, Radford-Smith G, Ropeleski M, Rosh J, Rubin D, Schultz M, Seidman E, Siegel C, Snapper S, Steinhart AH, Turner D

Publikováno v: Gastroenterology [Gastroenterology] 2024 Oct 09. Date of Electronic Publication: 2024 Oct 09.