Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Diego Yuri Pomè"'
1
Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide
Autor: Maria Fazzari, Giulia Lunghi, Pamela Fato, Maura Samarani, Erika Di Biase, Maria Grazia Ciampa, Diego Yuri Pomè, Simona Prioni, Manuela Valsecchi, Margherita Maggioni, Sandro Sonnino, Elena Chiricozzi, Laura Mauri
Publikováno v: Glycoconjugate Journal. 37:329-343
It has been recently reported by our group that GM1-oligosaccharide added to neuroblastoma cells or administered to mouse experimental model mimics the neurotrophic and neuroprotective properties of GM1 ganglioside. In addition to this, differently f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3577ac02658450d970b7a677587afd32
https://doi.org/10.1007/s10719-020-09919-x
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2
Parkinson’s disease recovery by GM1 oligosaccharide treatment in the B4galnt1 +/− mouse model
Autor: Elena Chiricozzi, Margherita Maggioni, Maria Fazzari, Erika Di Biase, Pamela Fato, Gianluca Verlengia, Gusheng Wu, Diego Yuri Pomè, Simona Prioni, Giulia Lunghi, Laura Mauri, Stefano Cattaneo, Robert Assini, Sandro Sonnino, Robert W. Ledeen, Nicoletta Loberto, Samar K. Alselehdar, Manuela Valsecchi, Maria Grazia Ciampa
Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1+/− mice, a model of sporadic Parkinson’s diseas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb574fc4f6a4bc857fd588d7d5193af4
http://link.springer.com/article/10.1038/s41598-019-55885-2
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3
GM 1 promotes TrkA‐mediated neuroblastoma cell differentiation by occupying a plasma membrane domain different from TrkA
Autor: Laura Mauri, Margherita Maggioni, Elena Chiricozzi, Maria Fazzari, Diego Yuri Pomè, Sandro Sonnino, Giulia Lunghi, Nicoletta Loberto, Riccardo Casellato, Erika Di Biase
Publikováno v: Journal of Neurochemistry. 149:231-241
Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface. To study the TrkA-GM1 interaction, we synt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925a5e3f3daeed1875ad2ed56c20136c
https://doi.org/10.1111/jnc.14685
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4
GM1 Oligosaccharide Crosses the Human Blood–Brain Barrier In Vitro by a Paracellular Route
Autor: Erika Di Biase, Giulia Lunghi, Margherita Maggioni, Maria Fazzari, Diego Yuri Pomè, Nicoletta Loberto, Maria Grazia Ciampa, Pamela Fato, Laura Mauri, Emmanuel Sevin, Fabien Gosselet, Sandro Sonnino, Elena Chiricozzi
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2020, 21 (8), pp.2858. ⟨10.3390/ijms21082858⟩
International Journal of Molecular Sciences, Vol 21, Iss 2858, p 2858 (2020)
International audience; Ganglioside GM1 (GM1) has been reported to functionally recover degenerated nervous system in vitro and in vivo, but the possibility to translate GM1's potential in clinical settings is counteracted by its low ability to overc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1fc376687842ebb88704840a92d30b04
http://europepmc.org/articles/PMC7215935
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5
Role of the GM1 ganglioside oligosaccharide portion in the TrkA-dependent neurite sprouting in neuroblastoma cells
Autor: Sandro Sonnino, Luca Palazzolo, Nicoletta Loberto, Ivano Eberini, Diego Yuri Pomè, Chiara Parravicini, Elena Chiricozzi, Erika Di Biase, Margherita Maggioni
Publikováno v: Journal of Neurochemistry. 143:645-659
GM1 ganglioside (II3 NeuAc-Gg4 Cer) is known to promote neurite formation in neuroblastoma cells by activating TrkA-MAPK pathway. The molecular mechanism by which GM1 is involved in the neurodifferentiation process is still unknown, however, in vitro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d382b5687d30f5ce8c2349aaa94c2e
https://doi.org/10.1111/jnc.14146
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7
Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: a computational and experimental study using epibatidine-related molecular probes
Autor: Clelia Dallanoce, Carlo Matera, Miriam Sciaccaluga, Cecilia Gotti, Marco De Amici, Diego Yuri Pomè, Sergio Fucile, Giovanni Grazioso
Publikováno v: Journal of Computer-Aided Molecular Design. 27:975-987
The binding mode of nicotinic agonists has been thoroughly investigated in the last decades. It is now accepted that the charged amino group is bound by a cation-π interaction to a conserved tryptophan residue, and that the aromatic moiety is projec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32032b5dec4576cab8942ce7297fc7b7
https://doi.org/10.1007/s10822-013-9694-y
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8
Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the α3β4 nicotinic acetylcholine receptor subtype
Autor: Miriam Sciaccaluga, Cecilia Gotti, Francesca Fasoli, Giovanni Grazioso, Carlo Matera, Clelia Dallanoce, Sergio Fucile, Marta Quadri, Diego Yuri Pomè, Marco De Amici
We report the design, synthesis and pharmacological screening of a group of analogues of anabaseine 2, a naturally occurring unselective nicotinic agonist. The novel nAChR ligands 5-15 were planned following a molecular modeling analysis which sugges
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57649dab88f2ed87faef4ed80f3ded89
http://hdl.handle.net/11573/927606
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9
Novel tricyclic Δ2-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: Synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes
Autor: Cecilia Gotti, Fabio Frigerio, Giovanni Grazioso, Clelia Dallanoce, Diego Yuri Pomè, Giuliana Martelli, Luca Pucci, Francesco Clementi, Marco De Amici, Carlo Matera
Publikováno v: Bioorganic & Medicinal Chemistry. 18:4498-4508
A group of novel tricyclic Delta(2)-isoxazolines (4b, 5b, 7a-b, and 8a-b) and 3-oxo-isoxazolidines (6a-b and 9a-b), structurally related to cytisine or norferruginine, was prepared through 1,3-dipolar cycloadditions involving suitable olefins and bro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7aa498060883ef7ba63ff4b8707acd2
https://doi.org/10.1016/j.bmc.2010.04.065
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10
Design of novel α7-subtype-preferring nicotinic acetylcholine receptor agonists: Application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies
Autor: Clelia Dallanoce, Carlo Matera, Marco De Amici, Giovanni Grazioso, Fabio Frigerio, Diego Yuri Pomè, Luca Pucci, Cecilia Gotti
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:6353-6357
In the search for nicotinic acetylcholine receptor (nAChRs) agonists with a selective affinity for the homomeric alpha7 channels, we carried out the virtual screening of a test set of potential nicotinic ligands, and adopted a simplified MM-PBSA appr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518665a36cb86e85e627d2b88bc2a458
https://doi.org/10.1016/j.bmcl.2009.09.073
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