Výsledky vyhledávání - "Diego Sebastián Insuasty Cepeda"

Akademický článek

Non-natural amino acids into LfcinB-derived peptides: effect in their (i) proteolytic degradation and (ii) cytotoxic activity against cancer cells

Autor: Diego Sebastián Insuasty-Cepeda, Andrea Carolina Barragán-Cárdenas, Natalia Ardila-Chantre, Karen Johanna Cárdenas-Martínez, Isabella Rincón-Quiñones, Yerly Vargas-Casanova, Alejandra Ochoa-Zarzosa, Joel Edmundo Lopez-Meza, Claudia Marcela Parra-Giraldo, Luis Fernando Ospina-Giraldo, Ricardo Fierro-Medina, Javier Eduardo García-Castañeda, Zuly Jenny Rivera-Monroy

Publikováno v: Royal Society Open Science, Vol 10, Iss 6 (2023)

The dimeric peptide 26[F]: (RRWQWRFKKLG)2-K-Ahx has exhibited a potent cytotoxic effect against breast cancer cell lines, with position 26 (F) being the most relevant for anti-cancer activity. In this investigation, six analogues of the 26[F] peptide

Externí odkaz: https://doaj.org/article/ea14e416fffe4469a68b6ca0844e6bec

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Akademický článek

LfcinB-Derived Peptides: Specific and punctual change of an amino acid in monomeric and dimeric sequences increase selective cytotoxicity in colon cancer cell lines

Autor: Andrea Carolina Barragán-Cárdenas, Diego Sebastián Insuasty-Cepeda, Karen Johanna Cárdenas-Martínez, Joel López-Meza, Alejandra Ochoa-Zarzosa, Adriana Umaña-Pérez, Zuly Jenny Rivera-Monroy, Javier Eduardo García-Castañeda

Publikováno v: Arabian Journal of Chemistry, Vol 15, Iss 8, Pp 103998- (2022)

We observed how a change of specific residues in LfcinB dimeric and palindromic sequences caused a notable increase in the cytotoxic activity against CaCo-2 cells while maintaining or even diminishing the level of the cytotoxic effect against normal

Externí odkaz: https://doaj.org/article/c3e57ce3fe854d73baa478160e5d8491

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Akademický článek

Evidence of Isomerization in the Michael-Type Thiol-Maleimide Addition: Click Reaction between L-Cysteine and 6-Maleimidehexanoic Acid

Autor: Víctor Alfonso Niño-Ramírez, Diego Sebastián Insuasty-Cepeda, Zuly Jenny Rivera-Monroy, Mauricio Maldonado

Publikováno v: Molecules, Vol 27, Iss 16, p 5064 (2022)

The reaction between L-cysteine (Cys) and 6-maleimidohexanoic acid (Mhx) in an aqueous medium at different levels of pH was analyzed via RP-HPLC, finding the presence of two reaction products throughout the evaluated pH range. By means of solid-phase

Externí odkaz: https://doaj.org/article/0a0692a9e20147649d3ed0629a3d08a4

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Gradient Retention Factor Concept Applied to Method Development for Peptide Analysis by Means of RP-HPLC

Autor: Nicolás Mateo González-López, Diego Sebastián Insuasty-Cepeda, Kevin Andrey Huertas-Ortiz, Juan Esteban Reyes-Calderón, Jorge Ariel Martínez-Ramírez, Ricardo Fierro-Medina, Zuly Jenny Rivera-Monroy, Javier Eduardo García-Castañeda

Publikováno v: ACS omega. 7(49)

Using the van Deemter model, the efficiency of three stationary phase systems in the analysis of a mixture of synthetic peptides was evaluated: (i) monolithic, (ii) packed, and (iii) core-shell columns, and it was shown that the efficiency of the mon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab62ba0d2bd8bbd4ca77c4229bd20d6
https://pubmed.ncbi.nlm.nih.gov/36530233

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Akademický článek

Synthetic Peptide Purification via Solid-Phase Extraction with Gradient Elution: A Simple, Economical, Fast, and Efficient Methodology

Autor: Diego Sebastián Insuasty Cepeda, Héctor Manuel Pineda Castañeda, Andrea Verónica Rodríguez Mayor, Javier Eduardo García Castañeda, Mauricio Maldonado Villamil, Ricardo Fierro Medina, Zuly Jenny Rivera Monroy

Publikováno v: Molecules, Vol 24, Iss 7, p 1215 (2019)

A methodology was implemented for purifying peptides in one chromatographic run via solid-phase extraction (SPE), reverse phase mode (RP), and gradient elution, obtaining high-purity products with good yields. Crude peptides were analyzed by reverse

Externí odkaz: https://doaj.org/article/740a517020d24db5a4a617e965f7428e

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Obtaining an immunoaffinity monolithic material: poly(GMA-co-EDMA) functionalized with an HPV-derived peptide using a thiol–maleimide reaction

Autor: Zuly Jenny Rivera-Monroy, Mauricio Maldonado, Javier Eduardo García-Castañeda, Diego Sebastián Insuasty-Cepeda

Publikováno v: RSC Advances. 11:4247-4255

Metabolites have great potential for the design of biomarkers, since their presence or absence provides valuable information about a biological system. In this context, polyclonal antibodies are important metabolites for diagnostic procedures, but in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8004b20d117c962f1691a4d4cbddf80
https://doi.org/10.1039/d0ra09095f

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Designing Short Peptides: A Sisyphean Task?

Autor: Victor Alfonso Niño‐Ramírez, Diego Sebastián Insuasty-Cepeda, Hector Manuel Pineda-Castañeda, Zuly Jenny Rivera-Monroy, Hernando Curtidor

Publikováno v: Current Organic Chemistry. 24:2448-2474

Over the last few years, short peptides have become a powerful tool in basic and applied research, with different uses like diagnostic, antimicrobial peptides, human health promoters or bioactive peptides, therapeutic treatments, templates for peptid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4e1d30f06745a62bdab093480895849
https://doi.org/10.2174/1385272824999200910094034

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