Imaging of Virus-Infected Cells with Soft X-ray Tomography

Autor: Damià Garriga, Francisco Javier Chichón, Bárbara M. Calisto, Diego S. Ferrero, Pablo Gastaminza, Eva Pereiro, Ana Joaquina Pérez-Berna

Publikováno v: Viruses, Vol 13, Iss 11, p 2109 (2021)

Viruses are obligate parasites that depend on a host cell for replication and survival. Consequently, to fully understand the viral processes involved in infection and replication, it is fundamental to study them in the cellular context. Often, viral

Externí odkaz: https://doaj.org/article/d4acd68852084dee8afed4bb2eeccdfa

Snapshots of a Non-Canonical RdRP in Action

Autor: Diego S. Ferrero, Michela Falqui, Nuria Verdaguer

Publikováno v: Viruses, Vol 13, Iss 7, p 1260 (2021)

RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRP) to ensure genome replication and transcription. The closed “right hand” architecture of RdRPs encircles seven conserved structural motifs (A to G) that regulate the polyme

Externí odkaz: https://doaj.org/article/0be9c1e6babc415dbd61415f0756fb73

Supramolecular arrangement of the full-length Zika virus NS5.

Autor: Diego S Ferrero, Victor M Ruiz-Arroyo, Nicolas Soler, Isabel Usón, Alba Guarné, Núria Verdaguer

Publikováno v: PLoS Pathogens, Vol 15, Iss 4, p e1007656 (2019)

Zika virus (ZIKV), a member of the Flaviviridae family, has emerged as a major public health threat, since ZIKV infection has been connected to microcephaly and other neurological disorders. Flavivirus genome replication is driven by NS5, an RNA-depe

Externí odkaz: https://doaj.org/article/66b88b0ff5d94d648b62c684ee14ffa1

The Structure of the RNA-Dependent RNA Polymerase of a Permutotetravirus Suggests a Link between Primer-Dependent and Primer-Independent Polymerases.

Autor: Diego S Ferrero, Mònica Buxaderas, José F Rodríguez, Núria Verdaguer

Publikováno v: PLoS Pathogens, Vol 11, Iss 12, p e1005265 (2015)

Thosea asigna virus (TaV), an insect virus belonging to the Permutatetraviridae family, has a positive-sense single-stranded RNA (ssRNA) genome with two overlapping open reading frames, encoding for the replicase and capsid proteins. The particular T

Externí odkaz: https://doaj.org/article/f3b0b2985397417c8029f04c4ef8211b

An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution

Autor: Mariana Castrillo-Briceño, F. Xavier Gomis-Rüth, Laura del Amo-Maestro, Petr Pompach, Theodoros Goulas, Jan J. Enghild, Amin Sagar, Diego S. Ferrero, Marta Taulés, Pau Bernadó, Carsten Scavenius

Publikováno v: Journal of molecular biology 433(13), 166954 (2021). doi:10.1016/j.jmb.2021.166954
Journal of Molecular Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Del Amo-Maestro, L, Sagar, A, Pompach, P, Goulas, T, Scavenius, C, Ferrero, D S, Castrillo-Briceño, M, Taulés, M, Enghild, J J, Bernadó, P & Gomis-Rüth, F X 2021, ' An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution ', Journal of Molecular Biology, vol. 433, no. 13, 166954 . https://doi.org/10.1016/j.jmb.2021.166954

Journal of molecular biology 433(13), 166954 (2021). doi:10.1016/j.jmb.2021.166954
Von Willebrand Factor (vWF), a 300-kDa plasma protein key to homeostasis, is cleaved at a single site by multi-domain metallopeptidase ADAMTS-13. vWF is the only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b474da55661bd537e617c436fccded
https://bib-pubdb1.desy.de/record/473522