Imaging of Virus-Infected Cells with Soft X-ray Tomography

Autor: Damià Garriga, Francisco Javier Chichón, Bárbara M. Calisto, Diego S. Ferrero, Pablo Gastaminza, Eva Pereiro, Ana Joaquina Pérez-Berna

Publikováno v: Viruses, Vol 13, Iss 11, p 2109 (2021)

Viruses are obligate parasites that depend on a host cell for replication and survival. Consequently, to fully understand the viral processes involved in infection and replication, it is fundamental to study them in the cellular context. Often, viral

Externí odkaz: https://doaj.org/article/d4acd68852084dee8afed4bb2eeccdfa

Snapshots of a Non-Canonical RdRP in Action

Autor: Diego S. Ferrero, Michela Falqui, Nuria Verdaguer

Publikováno v: Viruses, Vol 13, Iss 7, p 1260 (2021)

RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRP) to ensure genome replication and transcription. The closed “right hand” architecture of RdRPs encircles seven conserved structural motifs (A to G) that regulate the polyme

Externí odkaz: https://doaj.org/article/0be9c1e6babc415dbd61415f0756fb73

Dual role of the foot-and-mouth disease virus 3B1 protein in the replication complex: As protein primer and as an essential component to recruit 3Dpol to membranes

Autor: Cristina Ferrer-Orta, Diego S. Ferrero, Nuria Verdaguer

Publikováno v: PLOS Pathogens. 19:e1011373

Picornavirus genome replication takes place in specialized intracellular membrane compartments that concentrate viral RNA and proteins as well as a number of host factors that also participate in the process. The core enzyme in the replication machin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21032ab1aa28593825638fb114fdd2f3
https://doi.org/10.1371/journal.ppat.1011373

An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution

Autor: Mariana Castrillo-Briceño, F. Xavier Gomis-Rüth, Laura del Amo-Maestro, Petr Pompach, Theodoros Goulas, Jan J. Enghild, Amin Sagar, Diego S. Ferrero, Marta Taulés, Pau Bernadó, Carsten Scavenius

Publikováno v: Journal of molecular biology 433(13), 166954 (2021). doi:10.1016/j.jmb.2021.166954
Journal of Molecular Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Del Amo-Maestro, L, Sagar, A, Pompach, P, Goulas, T, Scavenius, C, Ferrero, D S, Castrillo-Briceño, M, Taulés, M, Enghild, J J, Bernadó, P & Gomis-Rüth, F X 2021, ' An Integrative Structural Biology Analysis of Von Willebrand Factor Binding and Processing by ADAMTS-13 in Solution ', Journal of Molecular Biology, vol. 433, no. 13, 166954 . https://doi.org/10.1016/j.jmb.2021.166954

Journal of molecular biology 433(13), 166954 (2021). doi:10.1016/j.jmb.2021.166954
Von Willebrand Factor (vWF), a 300-kDa plasma protein key to homeostasis, is cleaved at a single site by multi-domain metallopeptidase ADAMTS-13. vWF is the only

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b474da55661bd537e617c436fccded
https://bib-pubdb1.desy.de/record/473522

Structure and dsRNA-binding activity of the Birnavirus Drosophila X Virus VP3 protein

Autor: Diego S, Ferrero, Idoia, Busnadiego, Damià, Garriga, Pablo, Guerra, María Teresa, Martín, Leonor, Kremer, Isabel, Usón, José Francisco, Rodriguez, Nuria, Verdaguer

Publikováno v: J Virol

The birnavirus multifunctional protein VP3 plays an essential role in coordinating the virus life cycle and interacting with the capsid protein VP2, the RNA-dependent RNA polymerase VP1, and the double-stranded RNA (dsRNA) genome. Furthermore, the ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9692cd6f2e87289954d4163061cf05a0
https://pubmed.ncbi.nlm.nih.gov/33239452