Výsledky vyhledávání - "Diego O, Nolasco"

Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum

Autor: Diego O. Nolasco, Collin M. Stultz, Virginia M. Burger

Publikováno v: Journal of Biological Chemistry. 291:6706-6713

The traditional view of the structure-function paradigm is that a protein's function is inextricably linked to a well defined, three-dimensional structure, which is determined by the protein's primary amino acid sequence. However, it is now accepted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a836ac746316e5e866fe4f5694cf5a
https://doi.org/10.1074/jbc.r115.692590

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HD5 and HBD1 variants’ solvation potential energy correlates with their antibacterial activity against Escherichia coli

Autor: Diego O. Nolasco, Gabriel Fernandes, Állan S. Pires, Octavio L. Franco, Sérgio Amorim de Alencar, William F. Porto

Publikováno v: Biopolymers. 106:43-50

The structure-activity relationship of defensins is not clear. It is known that point mutations in HD5 and HBD1 could modify their activities; however, these mutations do not seem to alter their three-dimensional structures. Here, applying molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3248a779fadc14a5c200823f7a77d918
https://doi.org/10.1002/bip.22763

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Comparative transcriptomic analysis indicates genes associated with local and systemic resistance to Colletotrichum graminicola in maize

Autor: Ana Claudia Guerra Araujo, William F. Porto, Octavio L. Franco, Vívian de Jesus Miranda, Camila G. Freitas, Robert Pogue, Luciano Viana Cota, Gabriel Fernandes, Diego O. Nolasco, Simoni Campos Dias

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA

The hemibiotrophic fungus Colletotrichum graminicola may cause severe damage to maize, affecting normal development of the plant and decreasing grain yield. In this context, understanding plant defense pathways at the inoculation site and systemicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35566cc77fa9607f1d6c55ac13f1b393
http://europepmc.org/articles/PMC5449407

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Revealing a Novel Otubain-Like Enzyme from Leishmania infantum with Deubiquitinating Activity toward K48-Linked Substrate

Autor: Izabela Marques Dourado Bastos, Philippe Grellier, Kelly Grace Magalhães, Clênia dos Santos Azevedo, Jhonata L. Pereira, Rafael Corrêa, Jaime M. Santana, Bruna C. Guido, Diego O. Nolasco, Flávia Nader Motta

Publikováno v: Frontiers in Chemistry
Frontiers in Chemistry, Frontiers Media, 2017, 5
Repositório Institucional da UnB
Universidade de Brasília (UnB)
instacron:UNB

Deubiquitinating enzymes (DUBs) play an important role in regulating a variety of eukaryotic processes. In this context, exploring the role of deubiquitination in Leishmania infantum could be a promising alternative to search new therapeutic targets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dcb28cf4b2a47a6fc192d0405c2e9c4
https://hal.archives-ouvertes.fr/hal-01966413

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Mycobacterium tuberculosis Prolyl Oligopeptidase Induces In vitro Secretion of Proinflammatory Cytokines by Peritoneal Macrophages

Autor: Hugo de Almeida, Kelly Grace Magalhães, Andre F. Correa, Brina Portugal, Flávia Nader Motta, Diego O. Nolasco, Ana L. V. Atta, Jaime M. Santana, Izabela Marques Dourado Bastos, Francisco D. Vieira

Publikováno v: Frontiers in Microbiology

Tuberculosis (TB) is a disease that leads to death over 1 million people per year worldwide and the biological mediators of this pathology are poorly established, preventing the implementation of effective therapies to improve outcomes in TB. Host–

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880a38f0581b9d4d27753b81f4208b2d
https://doi.org/10.3389/fmicb.2017.00155

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Functional and structural insights on self-assembled nanofiber-based novel antibacterial ointment from antimicrobial peptides, bacitracin and gramicidin S

Autor: Denial Mahata, Octavio L. Franco, Diego O. Nolasco, Santi M. Mandal, Anupam Roy, Ludovico Migliolo

Publikováno v: The Journal of Antibiotics. 67:771-775

A novel antibacterial ointment using bacitracin, specific for Gram-positive bacteria, and gramicidin S, a highly toxic antibacterial peptide, was here developed showing broad-spectrum antibacterial activities against pathogenic strains with less toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4416c0d56c73d5a8eaf708e291cd5be1
https://doi.org/10.1038/ja.2014.70

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Native and recombinant Pg-AMP1 show different antibacterial activity spectrum but similar folding behavior

Autor: Diego O. Nolasco, Octavio L. Franco, William F. Porto

Publikováno v: Peptides. 55:92-97

Glycine-rich proteins (GRPs) derived from plants compose a family of proteins and peptides that share a glycine repeat domain and they can perform diverse functions. Two structural conformations have been proposed for GRPs: glycine loops arranged as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4593082437e23b24e5e6dc44d0b9065
https://doi.org/10.1016/j.peptides.2014.02.010

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