Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Diego Mourão-Sá"'
Autor:
Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Hernandez Moura Silva, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0247680 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0237773.].
Externí odkaz:
https://doaj.org/article/21d1f6bb95a349debe03d947808fbc31
Autor:
Jose Henrique Ledo, Ran Zhang, Luka Mesin, Diego Mourão-Sá, Estefania P Azevedo, Olga G Troyanskaya, Victor Bustos, Paul Greengard
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0237773 (2020)
Microglial cells play a key role in brain homeostasis from development to adulthood. Here we show the involvement of a site-specific phosphorylation of Presenilin 1 (PS1) in microglial development. Profiles of microglia-specific transcripts in differ
Externí odkaz:
https://doaj.org/article/d4ab345b9e074e9b86f224c51554c19b
Autor:
Diego Mourão-Sá, Paul Greengard, Ran Zhang, Luka Mesin, Jose Henrique Ledo, Olga G. Troyanskaya, Estefania P. Azevedo, Victor Bustos
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237773 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237773 (2020)
Microglial cells play a key role in brain homeostasis from development to adulthood. Here we show the involvement of a site-specific phosphorylation of Presenilin 1 (PS1) in microglial development. Profiles of microglia-specific transcripts in differ
Autor:
Francesco Barone, Stacey A Langan, Alice Y. Pollitt, Steven A. Sheardown, Caetano Reis e Sousa, Cécile Bénézech, Leyre Navarro-Núñez, Edina Schweighoffer, Nicholas Smithers, Diego Mourão-Sá, Kate L. Lowe, Craig E. Hughes, Victor L. J. Tybulewicz, Gerard B. Nash, Steve P. Watson, Brenda A. Finney
Publikováno v:
Blood. 119:1747-1756
The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation, and pe
Autor:
Fabio P. Mesquita-Santos, Diego Mourão-Sá, Christianne Bandeira-Melo, Patrícia T. Bozza, Marcelo T. Bozza, Adriana Vieira-de-Abreu, Elisabeth S. Magalhães, Hugo C. Castro-Faria-Neto, Andrea Surrage Calheiros
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 44:509-516
Recent studies have demonstrated an essential and nonredundant role for macrophage migration inhibitory factor (MIF) in asthma pathogenesis. Here we investigate the mechanisms involved in MIF-induced eosinophil activation. By using a model of allergi
Autor:
Diego Mourão-Sá, Craig A. Nash, Johannes A. Eble, Steve P. Watson, Leyre Navarro-Núñez, Yotis A. Senis, Sonia Severin, Alice Y. Pollitt
Publikováno v:
Journal of Biological Chemistry. 286:4107-4116
The C-type lectin-like receptor CLEC-2 signals via phosphorylation of a single cytoplasmic YXXL sequence known as a hem-immunoreceptor tyrosine-based activation motif (hemITAM). In this study, we show that phosphorylation of CLEC-2 by the snake toxin
Autor:
Brenda A. Finney, Alice Y. Pollitt, Craig E. Hughes, Diego Mourão-Sá, Leyre Navarro-Núñez, Steve P. Watson
Publikováno v:
Journal of Thrombosis and Haemostasis. 8:2328-2332
The C-type lectin receptor CLEC-2 is expressed primarily on the surface of platelets, where it is present as a dimer, and is found at low level on a subpopulation of other hematopoietic cells, including mouse neutrophils [1–4] Clustering of CLEC-2
Autor:
Inês Faro-Trindade, Ann M. Kerrigan, Caetano Reis e Sousa, Diego Mourão-Sá, Janet A. Willment, Gordon D. Brown, Johannes A. Eble, Philip R. Taylor, Kevin M. Dennehy
Publikováno v:
The Journal of Immunology. 182:4150-4157
CLEC-2 is a member of the “dectin-1 cluster” of C-type lectin-like receptors and was originally thought to be restricted to platelets. In this study, we demonstrate that murine CLEC-2 is also expressed by peripheral blood neutrophils, but only we
Autor:
Pedro Xavier-Elsas, Rodrigo T. Figueiredo, Alexandre dos Santos Pyrrho, Adriana Vieira-de-Abreu, Mariana S. Silveira, Elizabeth S. Magalhães, Maria Ignez C. Gaspar-Elsas, Heitor Siffert Pereira de Souza, Claudia N. Paiva, Diego Mourão-Sá, Marcelo T. Bozza, Patrícia T. Bozza, Helio S. Dutra
Publikováno v:
The FASEB Journal. 23:1262-1271
Macrophage migration inhibitory factor (MIF) participates in the pathogenesis of inflammatory diseases, including asthma, in which it enhances airway hypersensitivity and tissue eosinophilia. Herein, we investigated the role of MIF in eosinophilopoie
Autor:
Caetano Reis e Sousa, Neil C. Rogers, Diego Mourão-Sá, James R. Carlyle, Olivier Joffre, Oliver Schulz, Daniel J. Pennington, David Sancho
Publikováno v:
Journal of Clinical Investigation. 118:2098-2110
The mouse CD8alpha+ DC subset excels at cross-presentation of antigen, which can elicit robust CTL responses. A receptor allowing specific antigen targeting to this subset and its equivalent in humans would therefore be useful for the induction of an