SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells

Autor: María Eugenia Sáez, Lorena Carmona-Rodríguez, Diego Martínez-Rey, Alicia González-Martín, Mateo Paz-Cabezas, Noe Rodríguez-Rodríguez, Beatriz Pérez-Villamil, Emilia Mira

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)

Background Tumor-infiltrating lymphocytes (TILs), mainly CD8+ cytotoxic T lymphocytes (CTL), are linked to immune-mediated control of human cancers and response to immunotherapy. Tumors have nonetheless developed specific mechanisms that selectively

Externí odkaz: https://doaj.org/article/aef2d38bd03145a88acda5c70a3af14a

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

Autor: Emilia Mira, Lorena Carmona-Rodríguez, Beatriz Pérez-Villamil, Josefina Casas, María Jesús Fernández-Aceñero, Diego Martínez-Rey, Paula Martín-González, Ignacio Heras-Murillo, Mateo Paz-Cabezas, Manuel Tardáguila, Tim D. Oury, Silvia Martín-Puig, Rosa Ana Lacalle, Gemma Fabriás, Eduardo Díaz-Rubio, Santos Mañes

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Tumour vasculature influences drug delivery. Here, the authors show that SOD3 re-expression enhances doxorubicin delivery and effects through normalization of tumour vasculature via the HIF-2a/VE-cadherin pathway.

Externí odkaz: https://doaj.org/article/a5a223591ab94254855b6f9c6cd6f2c6

SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4

Autor: Santos Mañes, Diego Martínez-Rey, Lorena Carmona-Rodríguez, Emilia Mira

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
OncoImmunology, Vol 9, Iss 1 (2020)
Oncoimmunology
article-version (VoR) Version of Record

The conversion of a non-T cell-inflamed into a T cell-inflamed tumor microenvironment (TME) is a key to sensitizing tumors to T-cell-based immunotherapies. Recent data show that the extracellular superoxide dismutase (SOD3) alters endothelial basemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fefc1ad1ccd265920ddec45d6692e21
http://hdl.handle.net/10261/218385

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α

Autor: Manuel Tardaguila, Emilia Mira, María Jesús Fernández-Aceñero, Tim D. Oury, Ignacio Heras-Murillo, Rosa Ana Lacalle, Eduardo Díaz-Rubio, Silvia Martin-Puig, Paula Martin-Gonzalez, Beatriz Perez-Villamil, Lorena Carmona-Rodríguez, Santos Mañes, Mateo Paz-Cabezas, Diego Martínez-Rey, Josefina Casas, Gemma Fabriàs

Publikováno v: Repisalud
Instituto de Salud Carlos III (ISCIII)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Nature Communications
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid

One drawback of chemotherapy is poor drug delivery to tumor cells, due in part to hyperpermeability of the tumor vasculature. Extracellular superoxide dismutase (SOD3) is an antioxidant enzyme usually repressed in the tumor milieu. Here we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5251749380f7338ecfb962e7f34e954
http://hdl.handle.net/10261/173892