Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Diego M. Presman"'
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Whether phase-separation is involved in the organization of the transcriptional machinery and if it aids or inhibits the transcriptional process is a matter of intense debate. In this Mini Review, we will cover the current knowledge regardin
Externí odkaz:
https://doaj.org/article/ab6e40acafcc440282c543348acfd066
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Glucocorticoid receptors (GR) are thought to bind DNA as dimers or monomers, to regulate different transcription pathways. Here, the authors perform genome-wide studies on GRs with mutations that impair dimerization and provide evidence that monomeri
Externí odkaz:
https://doaj.org/article/e17e7e034ed64487b45fd4206fa584e1
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-20 (2020)
Abstract Background Functional compartmentalization has emerged as an important factor modulating the kinetics and specificity of biochemical reactions in the nucleus, including those involved in transcriptional regulation. The glucocorticoid recepto
Externí odkaz:
https://doaj.org/article/d65df99d185b415b9f201d1193ace4a2
Autor:
Martin Stortz, Diego M. Presman, Luciana Bruno, Paolo Annibale, Maria V. Dansey, Gerardo Burton, Enrico Gratton, Adali Pecci, Valeria Levi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The distribution of the transcription machinery among different sub-nuclear domains raises the question on how the architecture of the nucleus modulates the transcriptional response. Here, we used fluorescence fluctuation analyses to quantit
Externí odkaz:
https://doaj.org/article/ef356766e870405287f98d124f438e45
Autor:
Ville Paakinaho, Diego M. Presman, David A. Ball, Thomas A. Johnson, R. Louis Schiltz, Peter Levitt, Davide Mazza, Tatsuya Morisaki, Tatiana S. Karpova, Gordon L. Hager
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Transcription factors (TFs) are thought to regulate gene expression by stably binding to target DNA elements. Here, the authors use single-molecule tracking to analyse the dynamic behaviour of steroid receptors TFs and show that most specific interac
Externí odkaz:
https://doaj.org/article/da11fc1b218545cd940439b7efb072c6
Autor:
Erik W. Martin, Sayantan Chakraborty, Diego M. Presman, Francesco Tomassoni Ardori, Kyu-Seon Oh, Mary Kaileh, Lino Tessarollo, Myong-Hee Sung
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
NF-κB is a family of heterodimers and homodimers which are generated from subunits encoded by five genes. The predominant classical dimer RelA:p50 is presumed to operate as “NF-κB” in many contexts. However, there are several other dimer specie
Externí odkaz:
https://doaj.org/article/fc8177a5b3dc4703a9e9ffb3a21f10b7
Publikováno v:
Cell Reports, Vol 28, Iss 13, Pp 3523-3534.e2 (2019)
Summary: Transcription factors (TFs) must access chromatin to bind to their response elements and regulate gene expression. A widely accepted model proposes that only a special subset of TFs, pioneer factors, can associate with condensed chromatin an
Externí odkaz:
https://doaj.org/article/87332f9984ce4f0aa8b91c5d7b86f1a2
Autor:
Matthew D. Taves, Paul R. Mittelstadt, Diego M. Presman, Gordon L. Hager, Jonathan D. Ashwell
Publikováno v:
Cell Reports, Vol 26, Iss 13, Pp 3629-3642.e4 (2019)
Summary: Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine glucocorticoid
Externí odkaz:
https://doaj.org/article/33fa01fe09914ee986cf86dcb2ec674b
Autor:
Alba Jiménez-Panizo, Andrea Alegre-Martí, Theophilus T Tettey, Gregory Fettweis, Montserrat Abella, Rosa Antón, Thomas A Johnson, Sohyoung Kim, R Louis Schiltz, Israel Núñez-Barrios, Joan Font-Díaz, Carme Caelles, Annabel F Valledor, Paloma Pérez, Ana M Rojas, Juan Fernández-Recio, Diego M Presman, Gordon L Hager, Pablo Fuentes-Prior, Eva Estébanez-Perpiñá
Publikováno v:
Nucleic Acids Res
20 páginas, 7 figuras
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (
The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that controls metabolic and homeostatic processes essential for life. Although numerous crystal structures of the GR ligand-binding domain (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035f1b8140abc8c9d09b095720948efb
https://doi.org/10.1093/nar/gkac1119
https://doi.org/10.1093/nar/gkac1119
Autor:
Gregory Fettweis, Thomas A. Johnson, Brian Almeida-Prieto, Diego M. Presman, Gordon L. Hager, Diego Alvarez de la Rosa
Publikováno v:
bioRxiv
The mineralocorticoid and glucocorticoid receptors (MR and GR) are evolutionary related nuclear receptors with highly conserved DNA- and ligand-binding domains (DBD and LBD), which determine promiscuous activation by corticosteroid hormones (aldoster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f7e6c8fd9ca365109bddb866a4742b
https://europepmc.org/articles/PMC9928021/
https://europepmc.org/articles/PMC9928021/
