Výsledky vyhledávání - "Diego M Moreno"

Akademický článek

1,3,4-oxadiazoles as inhibitors of the atypical member of the BET family bromodomain factor 3 from Trypanosoma cruzi (TcBDF3)

Autor: Victoria L. Alonso, Andrea M. Escalante, Elvio Rodríguez Araya, Gianfranco Frattini, Luis E. Tavernelli, Diego M. Moreno, Ricardo L. E. Furlan, Esteban Serra

Publikováno v: Frontiers in Microbiology, Vol 15 (2024)

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects millions globally, with increasing urban cases outside of Latin America. Treatment is based on two compounds, namely, benznidazole (BZ) and nifurtimox, but chronic cases pose

Externí odkaz: https://doaj.org/article/625fa16de8e24adda2e8694cf21c87f1

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Akademický článek

Host-specific enzyme-substrate interactions in SPM-1 metallo-β-lactamase are modulated by second sphere residues.

Autor: Lisandro J González, Diego M Moreno, Robert A Bonomo, Alejandro J Vila

Publikováno v: PLoS Pathogens, Vol 10, Iss 1, p e1003817 (2014)

Pseudomonas aeruginosa is one of the most virulent and resistant non-fermenting Gram-negative pathogens in the clinic. Unfortunately, P. aeruginosa has acquired genes encoding metallo-β-lactamases (MβLs), enzymes able to hydrolyze most β-lactam an

Externí odkaz: https://doaj.org/article/7e572c3d8e484d8eb8cdc885e474b6b2

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Akademický článek

Updates on moleculARweb, the Swiss Portal for Chemistry and Structural Biology Education Using Augmented and now also Virtual Reality

Autor: Fabio Cortés Rodríguez, Facundo Dualde, Philippe Massiot, Gianfranco Frattini, Diego M. Moreno, Luciano A. Abriata

Publikováno v: CHIMIA, Vol 77, Iss 4 (2023)

We present a new activity on the moleculARweb platform on molecular symmetry elements, two more languages, a new marker-less augmented reality mode, and a new virtual reality tool for VR headsets.

Externí odkaz: https://doaj.org/article/5a67c14c98f4405299af49f99171b49c

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Akademický článek

Longitudinal Evolution of the Pseudomonas-Derived Cephalosporinase (PDC) Structure and Activity in a Cystic Fibrosis Patient Treated with β-Lactams

Autor: Claudia A. Colque, Andrea G. albarracín Orio, Pablo E. Tomatis, Gina Dotta, Diego M. Moreno, Laura G. Hedemann, Rachel A. Hickman, Lea M. Sommer, Sofía Feliziani, Alejandro J. Moyano, Robert A. Bonomo, Helle K. Johansen, Søren Molin, Alejandro J. Vila, Andrea M. Smania

Publikováno v: mBio, Vol 13, Iss 5 (2022)

ABSTRACT Traditional studies on the evolution of antibiotic resistance development use approaches that can range from laboratory-based experimental studies, to epidemiological surveillance, to sequencing of clinical isolates. However, evolutionary tr

Externí odkaz: https://doaj.org/article/70924af419ec406b88dabded5e47d448

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Akademický článek

Identification of key sequence features required for microRNA biogenesis in plants

Autor: Arantxa M. L. Rojas, Salvador I. Drusin, Uciel Chorostecki, Julieta L. Mateos, Belén Moro, Nicolas G. Bologna, Edgardo G. Bresso, Arnaldo Schapire, Rodolfo M. Rasia, Diego M. Moreno, Javier F. Palatnik

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

The secondary structure of miRNA precursor sequences is known to affect processing by DICER-like proteins. Here Rojas et al. show that additional sequence features also play a regulatory role in plants with nucleotide identity at unpaired positions s

Externí odkaz: https://doaj.org/article/e3152a8f99124b46a29fca906b6694b7

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2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode

Autor: Valentina Villamil, Maria F. Mojica, Brad Spellberg, Diego M. Moreno, James Spencer, Claudia Banchio, Alejandro J. Vila, Robert A. Bonomo, Verónica Martínez, Graciela Mahler, Philip Hinchliffe, George L. Drusano, Maria-Agustina Rossi

Publikováno v: Repositorio U. El Bosque
Universidad El Bosque
instacron:Universidad El Bosque
Hinchliffe, P, Moreno, D M, Rossi, M-A, Mojica, M F, Martinez, V, Villamil, V, Spellberg, B, Drusano, G L, Banchio, C, Mahler, G, Bonomo, R A & Spencer, J 2021, ' 2-Mercaptomethyl Thiazolidines (MMTZs) Inhibit All Metallo-β-Lactamase Classes by Maintaining a Conserved Binding Mode ', ACS Infectious Diseases, vol. 7, no. 9, pp. 2697-2706 . https://doi.org/10.1021/acsinfecdis.1c00194, https://doi.org/10.1021/acsinfecdis.1c00194
ACS Infect Dis

Metallo-β-lactamase (MBL) production in Gram-negative bacteria is an important contributor to β-lactam antibiotic resistance. Combining β-lactams with β-lactamase inhibitors (BLIs) is a validated route to overcoming resistance, but MBL inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca170f33eb191f60adbd8e767b6d3429
https://doi.org/10.1021/acsinfecdis.1c00194

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Cover Feature: Versatile Activity of a Copper(II) Complex Bearing a N 4 ‐Tetradentate Schiff Base Ligand with Reduced Oxygen Species (Eur. J. Inorg. Chem. 8/2022)

Autor: Micaela Richezzi, Joaquín Ferreyra, Juan Puzzolo, Lisandro Milesi, Claudia M. Palopoli, Diego M. Moreno, Christelle Hureau, Sandra R. Signorella

Publikováno v: European Journal of Inorganic Chemistry. 2022

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d02ab711babcfe0984ed19158f0c321
https://doi.org/10.1002/ejic.202200099

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Versatile Activity of a Copper(II) Complex Bearing a N 4 ‐Tetradentate Schiff Base Ligand with Reduced Oxygen Species

Autor: Micaela Richezzi, Joaquín Ferreyra, Juan Puzzolo, Lisandro Milesi, Claudia M. Palopoli, Diego M. Moreno, Christelle Hureau, Sandra R. Signorella

Publikováno v: European Journal of Inorganic Chemistry
European Journal of Inorganic Chemistry, 2022, 2022 (8), pp.e202101042. ⟨10.1002/ejic.202101042⟩

International audience; The reactivity of the Cu(II) complex of N,N’-bis(pyridin-2-ylmethylene)propane-1,3-diamine (py2pn), [Cu(py2pn)(ClO4)2], toward O2.− and H2O2 has been examined. The complex reacts with O2.− with fast second order kinetics

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257e805a64eb8ab7f685af569bc970e7
https://doi.org/10.1002/ejic.202101042

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MoleculARweb: A Web Site for Chemistry and Structural Biology Education through Interactive Augmented Reality out of the Box in Commodity Devices

Autor: Fabio Cortés Rodríguez, Diego M. Moreno, Jorge Salomon, Matteo Dal Peraro, Luciano A. Abriata, Mariana Roldan, Gianfranco Frattini, Hassan Martínez-Hung, Lucien Krapp, Sylvain Traeger, Lee Stemkoski

Publikováno v: RepHipUNR (UNR)
Universidad Nacional de Rosario
instacron:UNR
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Augmented/virtual realities (ARs/VRs) promise to revolutionize STEM education. However, most easy-to-use tools are limited to static visualizations, which limits the approachable content, whereas more interactive and dynamic alternatives require cost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9994a41a849bec2d57073f3e7a794a79

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Study of the role of Mg2+ in dsRNA processing mechanism by bacterial RNase III through QM/MM simulations

Autor: Diego M. Moreno, Salvador I. Drusin, Rodolfo M. Rasia

Publikováno v: JBIC Journal of Biological Inorganic Chemistry. 25:89-98

The ribonuclease III (RNase III) cleaves dsRNA in specific positions generating mature RNAs. RNase III enzymes play important roles in RNA processing, post-transcriptional gene expression, and defense against viral infection. The enzyme's active site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944ec383f510f715769710a5ce71d86c
https://doi.org/10.1007/s00775-019-01741-7

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