Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Diego Luis Medina"'
Autor:
Alessia Calcagni’, Leopoldo Staiano, Nicolina Zampelli, Nadia Minopoli, Niculin J. Herz, Giuseppe Di Tullio, Tuong Huynh, Jlenia Monfregola, Alessandra Esposito, Carmine Cirillo, Aleksandar Bajic, Mahla Zahabiyon, Rachel Curnock, Elena Polishchuk, Luke Parkitny, Diego Luis Medina, Nunzia Pastore, Peter J. Cullen, Giancarlo Parenti, Maria Antonietta De Matteis, Paolo Grumati, Andrea Ballabio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Batten disease, one of the most devastating types of neurodegenerative lysosomal storage disorders, is caused by mutations in CLN3. Here, we show that CLN3 is a vesicular trafficking hub connecting the Golgi and lysosome compartments. Proteo
Externí odkaz:
https://doaj.org/article/6b4c5ef6c8024f6aa64e8fc752ca2920
Autor:
Antonietta Tarallo, Carla Damiano, Sandra Strollo, Nadia Minopoli, Alessia Indrieri, Elena Polishchuk, Francesca Zappa, Edoardo Nusco, Simona Fecarotta, Caterina Porto, Marcella Coletta, Roberta Iacono, Marco Moracci, Roman Polishchuk, Diego Luis Medina, Paola Imbimbo, Daria Maria Monti, Maria Antonietta De Matteis, Giancarlo Parenti
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp 1-21 (2021)
Abstract Pompe disease is a metabolic myopathy due to acid alpha‐glucosidase deficiency. In addition to glycogen storage, secondary dysregulation of cellular functions, such as autophagy and oxidative stress, contributes to the disease pathophysiol
Externí odkaz:
https://doaj.org/article/c9d76b1dfda5478da27f60239b67fa37
Autor:
Gennaro Napolitano, Alessandra Esposito, Heejun Choi, Maria Matarese, Valerio Benedetti, Chiara Di Malta, Jlenia Monfregola, Diego Luis Medina, Jennifer Lippincott-Schwartz, Andrea Ballabio
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates
Externí odkaz:
https://doaj.org/article/0ca34c106f93485d8615cf33135d22a2
Autor:
Francesco Bellomo, Ester De Leo, Anna Taranta, Laura Giaquinto, Gianna Di Giovamberardino, Sandro Montefusco, Laura Rita Rega, Anna Pastore, Diego Luis Medina, Diego Di Bernardo, Maria Antonietta De Matteis, Francesco Emma
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12829 (2021)
Diagnosis and cure for rare diseases represent a great challenge for the scientific community who often comes up against the complexity and heterogeneity of clinical picture associated to a high cost and time-consuming drug development processes. Her
Externí odkaz:
https://doaj.org/article/98bad27755484d9aa5347e34f31a47fd
Publikováno v:
Cells, Vol 9, Iss 5, p 1186 (2020)
The MiT/TFE family of transcription factors (MITF, TFE3, and TFEB), which control transcriptional programs for autophagy and lysosome biogenesis have emerged as regulators of energy metabolism in cancer. Thus, their activation increases lysosomal cat
Externí odkaz:
https://doaj.org/article/9177d5d42b5d4ad3bfa972399ed09ecc
Autor:
Antonella Capuozzo, Sandro Montefusco, Vincenzo Cacace, Martina Sofia, Alessandra Esposito, Gennaro Napolitano, Eduardo Nusco, Elena Polishchuk, Maria Teresa Pizzo, Maria De Risi, Elvira De Leonibus, Nicolina Cristina Sorrentino, Diego Luis Medina
Publikováno v:
Mol Ther
Mucopolysaccharidosis type IIIA (MPS-IIIA) is an autosomal recessive disorder caused by mutations in SGSH involved in the degradation of heparan sulfate. MPS-IIIA presents severe neurological symptoms such as progressive developmental delay and cogni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3f587c91126773c40abf800d88d65d
https://doi.org/10.1016/j.ymthe.2022.01.037
https://doi.org/10.1016/j.ymthe.2022.01.037
Autor:
Diego Luis, Medina
Publikováno v:
Handbook of experimental pharmacologyReferences.
Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0cf8e33a90240e044fea9f2ed4a06e39
https://pubmed.ncbi.nlm.nih.gov/35879578
https://pubmed.ncbi.nlm.nih.gov/35879578
Autor:
Duarte C. Barral, Leopoldo Staiano, Cláudia Guimas Almeida, Dan F. Cutler, Emily R. Eden, Clare E. Futter, Antony Galione, André R. A. Marques, Diego Luis Medina, Gennaro Napolitano, Carmine Settembre, Otília V. Vieira, Johannes M. F. G. Aerts, Peace Atakpa‐Adaji, Gemma Bruno, Antonella Capuozzo, Elvira De Leonibus, Chiara Di Malta, Cristina Escrevente, Alessandra Esposito, Paolo Grumati, Michael J. Hall, Rita O. Teodoro, Susana S. Lopes, J. Paul Luzio, Jlenia Monfregola, Sandro Montefusco, Frances M. Platt, Roman Polishchuck, Maria De Risi, Irene Sambri, Chiara Soldati, Miguel C. Seabra
Publikováno v:
Traffic, 23(5), 238-269. WILEY
Funder: Maratona da Saúde
Funder: Royal Society Wolfson
Funder: Wellcome; Id: http://dx.doi.org/10.13039/100010269
Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles.
Funder: Royal Society Wolfson
Funder: Wellcome; Id: http://dx.doi.org/10.13039/100010269
Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5d231f62a432f3d967c8e877aee060
https://hdl.handle.net/1887/3479665
https://hdl.handle.net/1887/3479665
Publikováno v:
Traffic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::ee5d231f62a432f3d967c8e877aee060
Publikováno v:
Cell calcium. 69
Efficient functioning of lysosome is necessary to ensure the correct performance of a variety of intracellular processes such as degradation of cargoes coming from the endocytic and autophagic pathways, recycling of organelles, and signaling mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3cc43137476ecf105ddaa1a79359becd
https://pubmed.ncbi.nlm.nih.gov/28689729
https://pubmed.ncbi.nlm.nih.gov/28689729