Výsledky vyhledávání - "Diego Lopez Mateos"

Akademický článek

Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold

Autor: Phuong Tran Nguyen, Brandon John Harris, Diego Lopez Mateos, Adriana Hernández González, Adam Michael Murray, Vladimir Yarov-Yarovoy

Publikováno v: Channels, Vol 18, Iss 1 (2024)

ABSTRACTIon channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gatin

Externí odkaz: https://doaj.org/article/beab5ea70fd84c6f9e25b028bb4eafa2

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Akademický článek

Structural and Functional Characterization of a Novel Scorpion Toxin that Inhibits NaV1.8 via Interactions With the DI Voltage Sensor and DII Pore Module

Autor: Kiran George, Diego Lopez-Mateos, Tarek Mohamed Abd El-Aziz, Yucheng Xiao, Jake Kline, Hong Bao, Syed Raza, James D. Stockand, Theodore R. Cummins, Luca Fornelli, Matthew P. Rowe, Vladimir Yarov-Yarovoy, Ashlee H. Rowe

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Voltage-gated sodium channel NaV1.8 regulates transmission of pain signals to the brain. While NaV1.8 has the potential to serve as a drug target, the molecular mechanisms that shape NaV1.8 gating are not completely understood, particularly mechanism

Externí odkaz: https://doaj.org/article/0dc9b79a83a742afa9602e8aab884a62

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Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human NaV1.7 Channel

Autor: Khoa Ngo, Diego Lopez Mateos, Kyle Rouen, Yanxiao Han, Heike Wulff, Colleen E. Clancy, Vladimir Yarov-Yarovoy, Igor Vorobyov

Human voltage-gated sodium (hNaV) channels are responsible for initiating and propagating action potentials in excitable cells and mutations have been associated with numerous cardiac and neurological disorders. hNaV1.7 channels are expressed in peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c26d9c6554b211ac075f1a8dff23d500
https://doi.org/10.1101/2023.02.27.530360

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Structural Modeling of Peptide Toxin - Ion Channel Interactions using RosettaDock

Autor: Diego Lopez Mateos, Vladimir Yarov-Yarovoy

SUMMARYVoltage-gated ion channels play essential physiological roles in action potential generation and propagation. Peptidic toxins from animal venoms target ion channels and provide useful scaffolds for the rational design of novel channel modulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f798f4979028849c01b33545240b452
https://doi.org/10.1101/2022.06.29.498146

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The H3K4me1 histone mark recruits DNA repair to functionally constrained genomic regions in plants

Autor: Daniela Quiroz, Diego Lopez-Mateos, Kehan Zhao, Alice Pierce, Lissandro Ortega, Alissza Ali, Pablo Carbonell-Bejerano, Vladimir Yarov-Yarovoy, J. Grey Monroe

Mutation is the ultimate source of genetic variation. Mutation rate variability has been observed within plant genomes, but the underlying mechanisms have been unclear. We previously found that mutations occur less often in functionally constrained r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ee9515b6f7d371e5e9788ae3be2068a
https://doi.org/10.1101/2022.05.28.493846

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