Transcription Factor NRF2 Participates in Cell Cycle Progression at the Level of G1/S and Mitotic Checkpoints

Autor: Diego Lastra, Maribel Escoll, Antonio Cuadrado

Publikováno v: Antioxidants, Vol 11, Iss 5, p 946 (2022)

Transcription factor NRF2 is a master regulator of the multiple cytoprotective responses that confer growth advantages on a cell. However, its participation in the mechanisms that govern the cell division cycle has not been explored in detail. In thi

Externí odkaz: https://doaj.org/article/b36bf06ad32c48f0813244fabcef7b47

WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells

Autor: Maribel Escoll, Diego Lastra, Natalia Robledinos-Antón, Francisco Wandosell, Inés María Antón, Antonio Cuadrado

Publikováno v: Antioxidants, Vol 9, Iss 9, p 773 (2020)

Due to their high metabolic rate, tumor cells produce exacerbated levels of reactive oxygen species that need to be under control. Wiskott–Aldrich syndrome protein (WASP)-interacting protein (WIP) is a scaffold protein with multiple yet poorly unde

Externí odkaz: https://doaj.org/article/18d8d6349a8f44b0a5be5fa265d8707f

Perspectives on the Clinical Development of NRF2-Targeting Drugs

Autor: Diego, Lastra, Raquel, Fernández-Ginés, Gina, Manda, Antonio, Cuadrado

Publikováno v: Handbook of experimental pharmacology. 264

The transcription factor NRF2 (nuclear factor erythroid 2-related factor 2) triggers homeostatic responses against a plethora of environmental or endogenous deviations in redox metabolism, inflammation, proteostasis, etc. Therefore, pharmacological a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8e54d36a3bd344f8df99d2b2b88273de
https://pubmed.ncbi.nlm.nih.gov/32776282

Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas

Autor: Diego Lastra, Ricardo Gargini, Virginia Martínez-Marín, Raquel Fernández-Ginés, Natalia Robledinos-Antón, Marta Pajares, Antonio Cuadrado, Ana I. Rojo, Pilar López-Larrubia, Marta Mendiola, Maribel Escoll, Isabel Esteban

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Redox Biology
Redox Biology, Vol 30, Iss, Pp-(2020)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Biblos-e Archivo. Repositorio Institucional de la UAM

Transcription factor NRF2 orchestrates a cellular defense against oxidative stress and, so far, has been involved in tumor progression by providing a metabolic adaptation to tumorigenic demands and resistance to chemotherapeutics. In this study, we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115976887c0e0c3591c777a7e007d869
http://hdl.handle.net/10261/222386

WIP induces oxidant tolerance in glioblastoma cells through NRF2/KEAP1 axis regulation

Autor: Diego Lastra, Maribel Escoll, Natalia Robledinos-Antón, Antonio Cuadrado

Publikováno v: Free Radical Biology and Medicine. 165:54-55

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6344d30dcd8b80730822d4f9e40c5021
https://doi.org/10.1016/j.freeradbiomed.2020.12.419