Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Diego L, Viale"'
Autor:
Sabrina E. Vinzón, María V. Lopez, Eduardo G. A. Cafferata, Ariadna S. Soto, Paula M. Berguer, Luciana Vazquez, Leonora Nusblat, Andrea V. Pontoriero, Eduardo M. Belotti, Natalia R. Salvetti, Diego L. Viale, Ariel E. Vilardo, Martin M. Avaro, Estefanía Benedetti, Mara L. Russo, María E. Dattero, Mauricio Carobene, Maximiliano Sánchez-Lamas, Jimena Afonso, Mauro Heitrich, Alejandro E. Cristófalo, Lisandro H. Otero, Elsa G. Baumeister, Hugo H. Ortega, Alexis Edelstein, Osvaldo L. Podhajcer
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-15 (2023)
Abstract COVID-19 vaccines were originally designed based on the ancestral Spike protein, but immune escape of emergent Variants of Concern (VOC) jeopardized their efficacy, warranting variant-proof vaccines. Here, we used preclinical rodent models t
Externí odkaz:
https://doaj.org/article/ba99e3be03244ebfae597386425015da
Autor:
Osvaldo L. Podhajcer, Yuti Chernajovsky, David Gould, Cecilia Carbone, Eduardo G. Cafferata, Diego L. Viale, Patricia Blanco, María V. Lopez
Supplementary Data from Expression of a suicidal gene under control of the human secreted protein acidic and rich in cysteine (SPARC) promoter in tumor or stromal cells led to the inhibition of tumor cell growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032059c5669363577f4c0507552f5393
https://doi.org/10.1158/1535-7163.22485266.v1
https://doi.org/10.1158/1535-7163.22485266.v1
Autor:
Osvaldo L. Podhajcer, Guillermo Mazzolini, Cecilia Carbone, Diego L. Viale, Maria V. Lopez, Daniela R. Macció, Eduardo G. Cafferata
Purpose: A33 antigen is a membrane-bound protein expressed in intestinal epithelium that is overexpressed in 95% of primary and metastatic colorectal carcinomas but is absent in most epithelial tissues and tumor types. We hypothesized that A33 promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4052b4259e453780570b9e816edc083c
https://doi.org/10.1158/1078-0432.c.6517545.v1
https://doi.org/10.1158/1078-0432.c.6517545.v1
Autor:
Osvaldo L. Podhajcer, Guillermo Mazzolini, Cecilia Carbone, Diego L. Viale, Maria V. Lopez, Daniela R. Macció, Eduardo G. Cafferata
Supplementary Data from A Novel A33 Promoter–Based Conditionally Replicative Adenovirus Suppresses Tumor Growth and Eradicates Hepatic Metastases in Human Colon Cancer Models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b90c5b9d3422b184d7c58f82350ad7
https://doi.org/10.1158/1078-0432.22440177
https://doi.org/10.1158/1078-0432.22440177
Autor:
Osvaldo L. Podhajcer, Yuti Chernajovsky, David Gould, Cecilia Carbone, Eduardo G. Cafferata, Diego L. Viale, Patricia Blanco, María V. Lopez
The successful use of transcriptional targeting for cancer therapy depends on the activity of a given promoter inside the malignant cell. Because solid human tumors evolve as a “cross-talk” between the different cell types within the tumor, we hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3bef28bfe5f3e0ccf34f2b22f5a20c
https://doi.org/10.1158/1535-7163.c.6531863
https://doi.org/10.1158/1535-7163.c.6531863
Autor:
M Verónica Lopez, Diego L Viale, Eduardo G A Cafferata, Alicia I Bravo, Cecilia Carbone, David Gould, Yuti Chernajovsky, Osvaldo L Podhajcer
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5119 (2009)
The clinical efficacy of conditionally replicative oncolytic adenoviruses (CRAd) is still limited by the inefficient infection of the tumor mass. Since tumor growth is essentially the result of a continuous cross-talk between malignant and tumor-asso
Externí odkaz:
https://doaj.org/article/d79f19cd56fc43ba8289f110672aec01
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1651
Here we describe a collection of methods that have been adapted to isolate and modify tumor-specific promoters (TSPs ) to drive viral replication for cancer therapy and other uses. We will describe as examples the secreted protein acidic and rich in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be0948afc48d28da6abcbe6dc78abbfe
https://pubmed.ncbi.nlm.nih.gov/28801903
https://pubmed.ncbi.nlm.nih.gov/28801903
Autor:
Leonardo Sganga, Marcela F. Bolontrade, Mariana Garcia, Guillermo Mazzolini, Eduardo Piaggio, Diego L. Viale, Miguel A. Sorrentino, Osvaldo L. Podhajcer, Gustavo Sevlever, Anibal Robinson
Publikováno v:
Stem Cells and Development. 21:2689-2702
The homing properties of mesenchymal stromal c´ells (MSCs) toward tumors turn them into attractive tools for combining cell and gene therapy. The aim of this study was to select in a feasible way a human bone marrow-derived MSC subpopulation that mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a750a236433dc6f6d612b5033c21bced
https://doi.org/10.1089/scd.2011.0643
https://doi.org/10.1089/scd.2011.0643
Autor:
Eduardo G. Cafferata, M. Veronica Lopez, Cecilia Rotondaro, David Gould, Yuti Chernajovsky, Osvaldo L. Podhajcer, David T. Curiel, Diego L. Viale
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
We have previously designed a conditionally replicative oncolytic adenovirus (CRAd) named Ad-F512 that can target both the stromal and the malignant melanoma cell compartments. The replication capacity of this CRAd is driven by a 0.5-Kb SPARC promote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06be8ee75addae25bc88b1c519bde20
http://www.sciencedirect.com/science/article/pii/S0022202X15360279
http://www.sciencedirect.com/science/article/pii/S0022202X15360279
Autor:
Diego L. Viale, M. Veronica Lopez, David Gould, Eduardo G. Cafferata, Alicia I. Bravo, Yuti Chernajovsky, Cecilia Carbone, Osvaldo L. Podhajcer
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
PLoS ONE, Vol 4, Iss 4, p e5119 (2009)
PLoS ONE
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
PLoS ONE, Vol 4, Iss 4, p e5119 (2009)
PLoS ONE
The clinical efficacy of conditionally replicative oncolytic adenoviruses (CRAd) is still limited by the inefficient infection of the tumor mass. Since tumor growth is essentially the result of a continuous cross-talk between malignant and tumor-asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb432d1390307b423e7c103335a8f831
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005119
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005119