Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Diego J Walther"'
Autor:
Maik Grohmann, Paul Hammer, Maria Walther, Nils Paulmann, Andreas Büttner, Wolfgang Eisenmenger, Thomas C Baghai, Cornelius Schüle, Rainer Rupprecht, Michael Bader, Brigitta Bondy, Peter Zill, Josef Priller, Diego J Walther
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8956 (2010)
Brain serotonin (5-HT) neurotransmission plays a key role in the regulation of mood and has been implicated in a variety of neuropsychiatric conditions. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of 5-HT. Recently, w
Externí odkaz:
https://doaj.org/article/4d71d04faf67483681cb1b2a68553f9f
Autor:
Marc Trimborn, Mahdi Ghani, Diego J Walther, Monika Dopatka, Véronique Dutrannoy, Andreas Busche, Franziska Meyer, Stefanie Nowak, Jean Nowak, Claus Zabel, Joachim Klose, Veronica Esquitino, Masoud Garshasbi, Andreas W Kuss, Hans-Hilger Ropers, Susanne Mueller, Charlotte Poehlmann, Ioannis Gavvovidis, Detlev Schindler, Karl Sperling, Heidemarie Neitzel
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9242 (2010)
Mutations in the human gene MCPH1 cause primary microcephaly associated with a unique cellular phenotype with premature chromosome condensation (PCC) in early G2 phase and delayed decondensation post-mitosis (PCC syndrome). The gene encodes the BRCT-
Externí odkaz:
https://doaj.org/article/770b07381bfb4877a4b16fab25d1cd22
Autor:
Nils Paulmann, Maik Grohmann, Jörg-Peter Voigt, Bettina Bert, Jakob Vowinckel, Michael Bader, Masa Skelin, Marko Jevsek, Heidrun Fink, Marjan Rupnik, Diego J Walther
Publikováno v:
PLoS Biology, Vol 7, Iss 10, p e1000229 (2009)
While serotonin (5-HT) co-localization with insulin in granules of pancreatic beta-cells was demonstrated more than three decades ago, its physiological role in the etiology of diabetes is still unclear. We combined biochemical and electrophysiologic
Externí odkaz:
https://doaj.org/article/c8a8c11ecb4a4b6990c471c4648c2d34
Autor:
Andreas W. Kuss, Ildiko Racz, Lore Becker, Thomas Klopstock, Lillian Garrett, Lars R. Jensen, Markus Ralser, Jozef Gecz, Martin Hrabě de Angelis, Matthias Rath, Hans-Hilger Ropers, Martin Klingenspor, Eckhard Wolf, Juan Antonio Aguilar-Pimentel, Thure Adler, Wolfgang Wurst, Anke Van Dijck, Sabine Müller, Jan Rozman, Viola von Bohlen und Halbach, Andreas Zimmer, Kristin Moreth, Harry Scherthan, Katharina Blümlein, Martin B. Delatycki, Birgit Rathkolb, Diego J. Walther, Jochen Graw, R. Frank Kooy, Jerzy Adamski, Valerie Gailus-Durner, Oliver Puk, Helmut Fuchs, Sabine M. Hölter, Bettina Bert, Oliver von Bohlen und Halbach, Cornelia Prehn, Wolfgang Hans, Zornitza Stark, Monika Dopatka, Dirk H. Busch, Heidrun Fink
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Biochimica et biophysica acta : molecular basis of disease
Biochimica et biophysica acta / Molecular basis of disease 1865(9), 2083-2093 (2019). doi:10.1016/j.bbadis.2018.12.011
Biochimica et biophysica acta : molecular basis of disease
Biochimica et biophysica acta / Molecular basis of disease 1865(9), 2083-2093 (2019). doi:10.1016/j.bbadis.2018.12.011
Mutations in the X chromosomal tRNA 2'-O-methyltransferase FTSJ1 cause intellectual disability (ID). Although the gene is ubiquitously expressed affected individuals present no consistent clinical features beyond ID. In order to study the pathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7c5352c82f2abde8ba3f3cd43a40d0
https://hdl.handle.net/21.11116/0000-0003-587A-221.11116/0000-0003-587C-0
https://hdl.handle.net/21.11116/0000-0003-587A-221.11116/0000-0003-587C-0
Autor:
Korcan Ayata, Tobias Müller, Rodolfo de Paula Vieira, Thorsten Dürk, Sebastian Reuter, Diego J. Walther, Melanie Grimm, Stephan Sorichter, Daniel Duerschmied, Sanja Cicko, Marco Idzko, Christian Taube, J. Christian Virchow
Publikováno v:
American Journal of Respiratory and Critical Care Medicine, 187(5), 476-485
5-Hydroxytryptamine (5-HT) is involved in the pathogenesis of allergic airway inflammation (AAI). It is unclear, however, how 5-HT contributes to AAI and whether this depends on tryptophan hydroxylase (TPH) 1, the critical enzyme for peripheral 5-HT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52c71e758155f57b336049bc19b76e7
https://doi.org/10.1164/rccm.201208-1440oc
https://doi.org/10.1164/rccm.201208-1440oc
Autor:
Katharina Bluemlein, Maik Grohmann, Diego J. Walther, Nils Paulmann, Silke Stahlberg, Jakob Vowinckel, Markus Ralser
Publikováno v:
FEBS Letters
Febs Letters
Febs Letters
Highlights ► Histamine is covalently attached to protein-integrated glutamine residues. ► Transglutaminase II (TGM2) is catalyzing protein histaminylation in P815 mast cells. ► Histaminylation of a catalytic glutamine activates G proteins Gαq,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f10033bc2582760d15c5091507fed96
https://doi.org/10.1016/j.febslet.2012.09.027
https://doi.org/10.1016/j.febslet.2012.09.027
Publikováno v:
FEBS Journal. 278:4740-4755
Functional protein serotonylation is a newly recognized post-translational modification with the primary biogenic monoamine (PBMA) serotonin (5-HT). This covalent protein modification is catalyzed by transglutaminases (TGs) and, for example, acts in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e52b35848f294a263f03c3a3a44abbf
https://doi.org/10.1111/j.1742-4658.2011.08347.x
https://doi.org/10.1111/j.1742-4658.2011.08347.x
Autor:
Julia Kirchheiner, Josef Priller, Maik Grohmann, Diego J. Walther, Marion Lautenschlager, Peter Zill, Silke Stahlberg, Andreas Heinz, Kathrin Scheuch
Publikováno v:
Biological Psychiatry. 62:1288-1294
Background Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin (5-HT) biosynthesis. Although dysfunction of 5-HT neurotransmission has been implicated in a variety of neuropsychiatric conditions, the human TPH2 promoter has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8310cf2418dff672f877cc7c336c887
https://doi.org/10.1016/j.biopsych.2007.01.015
https://doi.org/10.1016/j.biopsych.2007.01.015
Publikováno v:
Journal of Neurochemistry. 102:1887-1894
Tryptophan hydroxylase (TPH) catalyses the first and rate limiting step in the biosynthesis of the neurotransmitter serotonin. There are two TPH isoenzymes in humans, encoded by two different genes: TPH1 and the recently described TPH2. We have expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10e9f8837f495c2a0d047a41d98fd5ac
https://doi.org/10.1111/j.1471-4159.2007.04664.x
https://doi.org/10.1111/j.1471-4159.2007.04664.x
Autor:
Margaret Nilsen, Michael Bader, Diego J. Walther, Lynn Loughlin, Ian Morecroft, Margaret R. MacLean, Katarina Kotnik, Yvonne Dempsie
Publikováno v:
Hypertension. 49:232-236
Tryptophan hydroxylase 1 catalyzes the rate-limiting step in the synthesis of serotonin in the periphery. Recently, it has been shown that expression of the tryptophan hydroxylase 1 gene is increased in lungs and pulmonary endothelial cells from pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b286c5f651953c53dac04b35f5920bbd
https://doi.org/10.1161/01.hyp.0000252210.58849.78
https://doi.org/10.1161/01.hyp.0000252210.58849.78