Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Diego Hidalgo Martinez"'
Autor:
Miguel Angel Alcalde, Diego Hidalgo-Martinez, Roque Bru Martínez, Susana Sellés-Marchart, Mercedes Bonfill, Javier Palazon
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Recent advancements in plant biotechnology have highlighted the potential of hairy roots as a biotechnological platform, primarily due to their rapid growth and ability to produce specialized metabolites. This study aimed to delve deeper into hairy r
Externí odkaz:
https://doaj.org/article/a60e002dae444ab7a25f657396f8be56
Publikováno v:
Plants, Vol 12, Iss 19, p 3363 (2023)
Centella asiatica is a medicinal plant with a rich tradition of use for its therapeutic properties. Among its bioactive compounds are centellosides, a group of triterpenoid secondary metabolites whose potent pharmacological activities have attracted
Externí odkaz:
https://doaj.org/article/a2555d8339f44de1b2a63739713227aa
Autor:
Edgar Perez-Matas, Diego Hidalgo-Martinez, Ainoa Escrich, Miguel Angel Alcalde, Elisabeth Moyano, Mercedes Bonfill, Javier Palazon
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Paclitaxel (PTX) and its derivatives are diterpene alkaloids widely used as chemotherapeutic agents in the treatment of various types of cancer. Due to the scarcity of PTX in nature, its production in cell cultures and plant organs is a major challen
Externí odkaz:
https://doaj.org/article/17808a83f7f0455089140f2d217ef975
Autor:
Miguel Angel Alcalde, Maren Müller, Sergi Munné-Bosch, Mariana Landín, Pedro Pablo Gallego, Mercedes Bonfill, Javier Palazon, Diego Hidalgo-Martinez
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Hairy roots are made after the integration of a small set of genes from Agrobacterium rhizogenes in the plant genome. Little is known about how this small set is linked to their hormone profile, which determines development, morphology, and levels of
Externí odkaz:
https://doaj.org/article/12095d20aea3424ba2a5671d8c3a9287
Autor:
Edgar Perez-Matas, Pascual Garcia-Perez, Begoña Miras-Moreno, Luigi Lucini, Mercedes Bonfill, Javier Palazon, Diego Hidalgo-Martinez
Publikováno v:
Plants, Vol 12, Iss 14, p 2696 (2023)
Taxus cell cultures are a reliable biotechnological source of the anticancer drug paclitaxel. However, the interplay between taxane production and other metabolic pathways during elicitation remains poorly understood. In this study, we combined untar
Externí odkaz:
https://doaj.org/article/550dc5229b14462b940aca5edc3e7dac
Autor:
Edgar Perez-Matas, Pascual Garcia-Perez, Mercedes Bonfill, Luigi Lucini, Diego Hidalgo-Martinez, Javier Palazon
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 887 (2023)
Elicited cell cultures of Taxus spp. are successfully used as sustainable biotechnological production systems of the anticancer drug paclitaxel, but the effect of the induced metabolomic changes on the synthesis of other bioactive compounds by elicit
Externí odkaz:
https://doaj.org/article/f0ac2eb5170a41a19821ae16504179a6
Publikováno v:
Metabolic Engineering. 77:174-187
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e797ed088ec71e626306da65ea59bd2c
https://doi.org/10.1016/j.ymben.2023.04.002
https://doi.org/10.1016/j.ymben.2023.04.002
Publikováno v:
Frontiers in Plant Science, Vol 11 (2020)
Efforts to express human therapeutic proteins in photosynthetic organisms have been described in the literature. Regarding microalgae, most of the research entailed a heterologous transformation of the chloroplast, but transformant cells failed to ac
Externí odkaz:
https://doaj.org/article/757e8de68d74432e84e2bcf9f450df62
Publikováno v:
ACS synthetic biology, vol 10, iss 4
The living cell possesses extraordinary molecular and biochemical mechanisms by which to recognize and efficiently remove foreign, damaged, or denatured proteins. This essential function has been a barrier to the overexpression of recombinant protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9f01bb2d9c308eb6eaa236ab6d55f5
https://doi.org/10.1021/acssynbio.0c00610
https://doi.org/10.1021/acssynbio.0c00610
Autor:
Diego Hidalgo Martinez, Yanxin Shen, Anastasios Melis, Ujwala Warek, Chengalrayan Kudithipudi, Raja S. Payyavula, James Strickland, Dongmei Xu
Publikováno v:
Planta, vol 251, iss 4
Main conclusionThe role of six alkaloid biosynthesis genes in the process of nicotine accumulation in tobacco was investigated. Downregulation of ornithine decarboxylase, arginine decarboxylase, and aspartate oxidase resulted in viable plants with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7df69811205218048d6d5762f1ab28
https://doi.org/10.1007/s00425-020-03387-1
https://doi.org/10.1007/s00425-020-03387-1