Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Diego Grassi"'
Autor:
Diego Grassi, Agata Idziak, Antony Lee, Ivo Calaresu, Jean-Baptiste Sibarita, Laurent Cognet, U. Valentin Nägerl, Laurent Groc
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112478- (2023)
Summary: The extracellular space (ECS) and its constituents play a crucial role in brain development, plasticity, circadian rhythm, and behavior, as well as brain diseases. Yet, since this compartment has an intricate geometry and nanoscale dimension
Externí odkaz:
https://doaj.org/article/a71c2a25120442fd9c5a13de20c4ab19
Publikováno v:
Revista de Ciências Agroveterinárias, Vol 20, Iss 3 (2021)
Weeds affect various crops worldwide, causing low yields and, therefore, significant economic losses. These losses can be minimized by the use of herbicides such as glyphosate. However, the efficiency of glyphosate depends on the type of agrochemical
Externí odkaz:
https://doaj.org/article/6fb8c251c12f4644ab42e9aa8e73c8df
Autor:
Uxía Nogueira-Recalde, Irene Lorenzo-Gómez, Francisco J. Blanco, María I. Loza, Diego Grassi, Valery Shirinsky, Ivan Shirinsky, Martin Lotz, Paul D. Robbins, Eduardo Domínguez, Beatriz Caramés
Publikováno v:
EBioMedicine, Vol 45, Iss , Pp 588-605 (2019)
Background: Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was to identify molecules to prevent OA by r
Externí odkaz:
https://doaj.org/article/c63026e5761746c8824accf8de17ff70
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 248-262 (2019)
We recently identified a truncated and phosphorylated form of α-synuclein, pα-syn*, as a key neurotoxic α-synuclein species found in cultured neurons, as well as in mouse and Parkinson's disease patients' brains. Small pα-syn* aggregates localize
Externí odkaz:
https://doaj.org/article/86b28ea806a14f0397ab5a48f22af994
Autor:
Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, Luise Angelini, Heike Fuhrmann-Stroissnigg, Ming Xu, Yuan Yuan Ling, Kendra I. Melos, Tamar Pirtskhalava, Christina L. Inman, Collin McGuckian, Erin A. Wade, Jonathon I. Kato, Diego Grassi, Mark Wentworth, Christin E. Burd, Edgar A. Arriaga, Warren L. Ladiges, Tamara Tchkonia, James L. Kirkland, Paul D. Robbins, Laura J. Niedernhofer
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 18-28 (2018)
Background: Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmac
Externí odkaz:
https://doaj.org/article/02bd6a51774a495f90e8c345736d54df
Autor:
Heike Fuhrmann-Stroissnigg, Yuan Yuan Ling, Jing Zhao, Sara J. McGowan, Yi Zhu, Robert W. Brooks, Diego Grassi, Siobhan Q. Gregg, Jennifer L. Stripay, Akaitz Dorronsoro, Lana Corbo, Priscilla Tang, Christina Bukata, Nadja Ring, Mauro Giacca, Xuesen Li, Tamara Tchkonia, James L. Kirkland, Laura J. Niedernhofer, Paul D. Robbins
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The accumulation of senescent cells is thought to contribute to the age-associated decline in tissue function. Here, the authors identify HSP90 inhibitors as a new class of senolytic compounds in an in vitro screening and show that administration of
Externí odkaz:
https://doaj.org/article/6370fcbecaf7452cab92818e472747d7
Autor:
Sebastián Dupraz, Diego Grassi, Diana Karnas, Alvaro F Nieto Guil, David Hicks, Santiago Quiroga
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54462 (2013)
Axonal regeneration is an essential condition to re-establish functional neuronal connections in the injured adult central nervous system (CNS), but efficient regrowth of severed axons has proven to be very difficult to achieve. Although significant
Externí odkaz:
https://doaj.org/article/914fb675a18c48aa9dbcd7b42344e55e
Autor:
Marta Garcia-Contreras, Antonio L. Amelio, Paul D. Robbins, Akaitz Dorronsoro, Ruenn Chai Lai, Adrian Reich, Lana Corbo, Donna B. Stolz, Camillo Ricordi, Donald G. Phinney, Laura J. Niedernhofer, Tianpeng Zhang, Siddaraju V. Boregowda, Sai Kiang Lim, Robert W. Brooks, Mohammad Fallahi, Johnny Huard, Sara J. McGowan, Luise Angelini, Aiping Lu, Diego Grassi, Fernando E. Santiago, Mitra Lavasani
Publikováno v:
Aging Cell
Aging drives progressive loss of the ability of tissues to recover from stress, partly through loss of somatic stem cell function and increased senescent burden. We demonstrate that bone marrow‐derived mesenchymal stem cells (BM‐MSCs) rapidly sen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ecf393666111ecbb0e4eaa4ad84ba0c
https://doi.org/10.1111/acel.13337
https://doi.org/10.1111/acel.13337
Soils are the principal environmental fate of pesticides in agricultural areas. Thus, the kinetics, extension, and strength of the adsorption process become critical. Dichlorvos (DDVP) is an organophosphorous pesticide that is used both in agricultur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd2ae81eec5c95325536a4b24e3a0cbe
https://doi.org/10.21203/rs.3.rs-133555/v1
https://doi.org/10.21203/rs.3.rs-133555/v1
Autor:
Christina L. Inman, Jonathon I. Kato, Yi Zhu, Collin A. McGuckian, Tamara Tchkonia, Kendra I. Melos, Diego Grassi, Tamar Pirtskhalava, Mark A. Wentworth, Paul D. Robbins, James L. Kirkland, Yuan Yuan Ling, Ming Xu, Edgar A. Arriaga, Laura J. Niedernhofer, Warren Ladiges, Matthew J. Yousefzadeh, Luise A. Angelini, Erin A. Wade, Christin E. Burd, Sara J. McGowan, Heike Fuhrmann-Stroissnigg
Publikováno v:
EBioMedicine
Background Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7947fab5e0881cf576a4d872fec951bc
https://doi.org/10.1016/j.ebiom.2018.09.015
https://doi.org/10.1016/j.ebiom.2018.09.015