Výsledky vyhledávání - "Diego Ghislieri"

Chemische Fertigungssysteme: Kontrolle auf mehreren Ebenen für die divergente, kontinuierliche und vielstufige Synthese von pharmazeutisch aktiven Wirkstoffen

Autor: Diego Ghislieri, Peter H. Seeberger, Kerry Gilmore

Publikováno v: Angewandte Chemie. 127:688-692

Wahrend kontinuierliche chemische Prozesse in der akademischen Forschung und der Industrie untersucht werden, werden nach wie vor praktisch alle pharmazeutisch aktiven Wirkstoffe (APIs; active pharmaceutical ingredients) uber eine Abfolge einzelner B

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https://doi.org/10.1002/ange.201409765

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Deracemisierung durch simultane bio-oxidative Racematspaltung und Stereoinversion

Autor: Joerg H. Schrittwieser, Eva-Maria Fischereder, Nicholas J. Turner, Peter Macheroux, Wolfgang Kroutil, Elisabeth Fuchs, Bas Groenendaal, Diego Ghislieri, Barbara Grischek, Silvia Wallner, Johann H. Sattler, Verena Resch

Publikováno v: Angewandte Chemie. 126:3805-3809

Deracemisierung, also die Umwandlung eines Racemats in ein enantiomerenreines Produkt mit theoretisch 100 % Ausbeute und 100 % ee, stellt eine attraktive, aber auch anspruchsvolle Option fur die asymmetrische Synthese dar. Hier beschreiben wir ein ne

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https://doi.org/10.1002/ange.201400027

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A Regio- and Stereoselective ω-Transaminase/Monoamine Oxidase Cascade for the Synthesis of Chiral 2,5-Disubstituted Pyrrolidines

Autor: Nicholas J. Turner, Jennifer Hopwood, Elaine O'Reilly, Diego Ghislieri, Cesar Iglesias, Richard C. Lloyd, James L. Galman

Publikováno v: Angewandte Chemie
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
O'Reilly, E, Iglesias, C, Ghislieri, D, Hopwood, J, Galman, J L, Lloyd, R C & Turner, N J 2014, ' A regio-and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines ', Angewandte Chemie-International Edition, vol. 53, no. 9, pp. 2447-2450 . https://doi.org/10.1002/anie.201309208

Biocatalytic approaches to the synthesis of optically pure chiral amines, starting from simple achiral building blocks, are highly desirable because such motifs are present in a wide variety of important natural products and pharmaceutical compounds.

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Deracemisation of benzylisoquinoline alkaloids employing monoamine oxidase variants

Autor: Verena Resch, Simon C. Willies, Bas Groenendaal, Barbara Grischek, Johann H. Sattler, Joerg H. Schrittwieser, Diego Ghislieri, Ian Rowles, Wolf-Dieter Lienhart, Nicholas J. Turner, Wolfgang Kroutil, Eva-Maria Fischereder

Publikováno v: Catal. Sci. Technol.. 4:3657-3664

Chemo-enzymatic deracemisation was applied to obtain the (S)-enantiomer of 1-benzylisoquinolines from the racemate in high isolated yield (up to 85%) and excellent optical purity (ee > 97%). The one-pot deracemisation protocol encompassed enantiosele

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https://doi.org/10.1039/c4cy00642a

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Monoamine Oxidase (MAO-N) Catalyzed Deracemization of Tetrahydro-β-carbolines: Substrate Dependent Switch in Enantioselectivity

Autor: Anthony P. Green, Nicholas J. Turner, Simon C. Willies, Diego Ghislieri, Deborah Houghton

Publikováno v: ACS Catalysis. 3:2869-2872

The tetrahydro-β-carboline (THBC) ring system is an important structural motif found in a large number of bioactive alkaloid natural products. Herein we report a broadly applicable method for the synthesis of enantiomerically pure β-carbolines via

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https://doi.org/10.1021/cs400724g

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Synthetic cascades are enabled by combining biocatalysts with artificial metalloenzymes

Autor: Diego Ghislieri, Thomas R. Ward, Nicholas J. Turner, Ekaterina Churakova, Yvonne M. Wilson, Livia Knörr, Daniel Häussinger, Tommaso Quinto, Marc Dürrenberger, Valentin Köhler, Frank Hollmann

Publikováno v: Nature Chemistry. 5:93-99

Enzymatic catalysis and homogeneous catalysis offer complementary means to address synthetic challenges, both in chemistry and in biology. Despite its attractiveness, the implementation of concurrent cascade reactions that combine an organometallic c

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https://doi.org/10.1038/nchem.1498

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Chemical assembly systems: layered control for divergent, continuous, multistep syntheses of active pharmaceutical ingredients

Autor: Diego Ghislieri, Kerry Gilmore, Peter H. Seeberger

Publikováno v: Angewandte Chemie (International ed. in English). 54(2)

While continuous chemical processes have attracted both academic and industrial interest, virtually all active pharmaceutical ingredients (APIs) are still produced by using multiple distinct batch processes. To date, methods for the divergent multist

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https://pubmed.ncbi.nlm.nih.gov/25414136

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