Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Diego Forni"'
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT CpG and UpA dinucleotides are under-represented in vertebrate genomes, whereas most invertebrates only show a bias against UpA. RNA viruses are thought to have evolved genomes that resemble the dinucleotide composition of their hosts, possib
Externí odkaz:
https://doaj.org/article/3806efd6ac1044b9877ff9a7fd989e5d
SARS-CoV-2 ORF3c impairs mitochondrial respiratory metabolism, oxidative stress, and autophagic flux
Autor:
Alessandra Mozzi, Monica Oldani, Matilde E. Forcella, Chiara Vantaggiato, Gioia Cappelletti, Chiara Pontremoli, Francesca Valenti, Diego Forni, Marina Saresella, Mara Biasin, Manuela Sironi, Paola Fusi, Rachele Cagliani
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107118- (2023)
Summary: Coronaviruses encode a variable number of accessory proteins that are involved in host-virus interaction, suppression of immune responses, or immune evasion. SARS-CoV-2 encodes at least twelve accessory proteins, whose roles during infection
Externí odkaz:
https://doaj.org/article/487a1ecd78f6489fbc147dbbda56c521
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Vaccinia virus (VACV) was used for smallpox eradication, but its ultimate origin remains unknown. The genetic relationships among vaccine stocks are also poorly understood. We analyzed 63 vaccine strains with different origin, as well horsep
Externí odkaz:
https://doaj.org/article/6793acc7732448eba0db9243e555a0c1
Publikováno v:
mSphere, Vol 8, Iss 2 (2023)
ABSTRACT The ongoing worldwide monkeypox outbreak is caused by viral lineages (globally referred to as hMPXV1) that are related to but distinct from clade IIb MPXV viruses transmitted within Nigeria. Analysis of the genetic differences has indicated
Externí odkaz:
https://doaj.org/article/4f588c646d9a43598257cb704a28b2c9
Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis.
Autor:
Sara Mascheretti, Diego Forni, Valentina Lampis, Luca Fumagalli, Stéphane Paquin, Till F M Andlauer, Wei Wang, Ginette Dionne, Mara R Brendgen, Frank Vitaro, Isabelle Ouellet-Morin, Guy Rouleau, Jean-Philippe Gouin, Sylvana Côté, Richard E Tremblay, Gustavo Turecki, Gabrielle Garon-Carrier, Michel Boivin, Marco Battaglia
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285263 (2023)
Both common pain and anxiety problems are widespread, debilitating and often begin in childhood-adolescence. Twin studies indicate that this co-occurrence is likely due to shared elements of risk, rather than reciprocal causation. A joint genome-wide
Externí odkaz:
https://doaj.org/article/2fe6f76d4d0e446ea699852159a03249
Autor:
Ganna Galitska, Alessandra Coscia, Diego Forni, Lars Steinbrueck, Simone De Meo, Matteo Biolatti, Marco De Andrea, Rachele Cagliani, Agata Leone, Enrico Bertino, Thomas Schulz, Angela Santoni, Santo Landolfo, Manuela Sironi, Cristina Cerboni, Valentina Dell’Oste
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Human cytomegalovirus (HCMV) infection often leads to systemic disease in immunodeficient patients and congenitally infected children. Despite its clinical significance, the exact mechanisms contributing to HCMV pathogenesis and clinical outcomes hav
Externí odkaz:
https://doaj.org/article/78f4b8017276476cb11dc335eb2a17b4
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1384-1395 (2019)
Human viral hepatitis, a major cause of morbidity and mortality worldwide, is caused by highly diverse viruses with different genetic, ecological, and pathogenetic features. Technological advances that allow throughput sequencing of viral genomes, as
Externí odkaz:
https://doaj.org/article/25d50495fece48e4b39fc67d3ceb4587
Autor:
Diego Forni, Rachele Cagliani, Uberto Pozzoli, Alessandra Mozzi, Federica Arrigoni, Luca De Gioia, Mario Clerici, Manuela Sironi
Publikováno v:
Viruses, Vol 14, Iss 5, p 1095 (2022)
Four endemic coronaviruses infect humans and cause mild symptoms. Because previous analyses were based on a limited number of sequences and did not control for effects that affect molecular dating, we re-assessed the timing of endemic coronavirus eme
Externí odkaz:
https://doaj.org/article/80886e5dfbaf4ed99812fb5b81ef0120
Autor:
Alessandra Mozzi, Matteo Biolatti, Rachele Cagliani, Diego Forni, Valentina Dell'Oste, Chiara Pontremoli, Chiara Vantaggiato, Uberto Pozzoli, Mario Clerici, Santo Landolfo, Manuela Sironi
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008476 (2020)
Cytomegaloviruses (order Herpesvirales) display remarkable species-specificity as a result of long-term co-evolution with their mammalian hosts. Human cytomegalovirus (HCMV) is exquisitely adapted to our species and displays high genetic diversity. W
Externí odkaz:
https://doaj.org/article/b71be8ab30674148b7b21ed9396b1bb4
Autor:
Nadia Barizzone, Rachele Cagliani, Chiara Basagni, Ferdinando Clarelli, Laura Mendozzi, Cristina Agliardi, Diego Forni, Martina Tosi, Elisabetta Mascia, Francesco Favero, Davide Corà, Lucia Corrado, Melissa Sorosina, Federica Esposito, Miriam Zuccalà, Domizia Vecchio, Maria Liguori, Cristoforo Comi, Giancarlo Comi, Vittorio Martinelli, Massimo Filippi, Maurizio Leone, Filippo Martinelli-Boneschi, Domenico Caputo, Manuela Sironi, Franca Rosa Guerini, Sandra D’Alfonso
Publikováno v:
Genes, Vol 12, Iss 10, p 1607 (2021)
Known multiple sclerosis (MS) susceptibility variants can only explain half of the disease’s estimated heritability, whereas low-frequency and rare variants may partly account for the missing heritability. Thus, here we sought to determine the occu
Externí odkaz:
https://doaj.org/article/ce9bdd4fc838408580ea93cf8dcaa66c