Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Diego Favretto"'
PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients
Autor:
Nagua Giurici, Diego Favretto, Antonella Colombini, Raffaella Franca, Irene Del Rizzo, Andrea Biondi, Franco Locatelli, Alessandro Ventura, Giuliana Decorti, Gabriele Stocco, S. Martellossi, Marco Pelin, Franca Fagioli, Elena Barisone, Marco Rabusin, Luciana Vinti
Publikováno v:
The Pharmacogenomics Journal. 20:415-425
The aim of the study was to validate the impact of the single-nucleotide polymorphism rs2413739 (T > C) in the PACSIN2 gene on thiopurines pharmacological parameters and clinical response in an Italian cohort of pediatric patients with acute lymphobl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771b4ee24555954fa1bbef676201b397
https://doi.org/10.1038/s41397-019-0130-0
https://doi.org/10.1038/s41397-019-0130-0
Autor:
Gabriele Stocco, Eva Cuzzoni, Annalisa Marcuzzi, Giovanni Montini, Elena Monti, Marco Pelin, Diego Favretto, Andrea Pasini, Luciana Ghio, Claudio La Scola, Francesca Mencarelli, Giuliana Decorti, William Morello, Raffaella Franca, Marianna Lucafò, Sara De Iudicibus
Publikováno v:
European Journal of Clinical Pharmacology. 75:1675-1683
Purpose: Idiopathic nephrotic syndrome (INS) is the most frequent form of childhood nephrotic syndrome. Steroids represent the best therapeutic option; however, inter-individual differences in their efficacy and side effects have been reported. To da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b57b05810f208e3c7c7e5ee8ae59a66
https://doi.org/10.1007/s00228-019-02749-3
https://doi.org/10.1007/s00228-019-02749-3
Autor:
Matteo Bramuzzo, Gabriele Stocco, Eva Cuzzoni, Tania Silvestri, Oriano Radillo, Patrizia Alvisi, Alessandro Ventura, Giuliana Decorti, Stefano Martelossi, Martina Pozzi Mucelli, Adriana Cifù, Martina Fabris, Diego Favretto, Doriana Lacorte, Andrea Taddio, Marianna Lucafò, Samuele Naviglio
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 68:37-44
Objectives: Anti-tumor necrosis factor antibodies have led to a revolution in the treatment of inflammatory bowel diseases (IBD); however, a sizable proportion of patients does not respond to therapy. There is increasing evidence suggesting that trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da1713f3c133a2aeb55b4147cde5a69
https://doi.org/10.1097/mpg.0000000000002112
https://doi.org/10.1097/mpg.0000000000002112
Autor:
Gabriele Stocco, Fulvia Vascotto, Alessandro Ventura, Adriana Cifù, Marianna Lucafò, Matteo Bramuzzo, Francesca De Pellegrin, Stefano Martelossi, Debora Curci, Diego Favretto, Martina Fabris, Samuele Naviglio, Giuliana Decorti
OBJECTIVES Therapeutic drug monitoring is becoming increasingly important in clinical decision-making in children with inflammatory bowel disease (IBD). However, enzyme-linked immunosorbent assay (ELISA) assays do not allow results to be provided in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50aa24470e6d71abdf27ed9f7bec012f
https://journals.lww.com/jpgn/fulltext/2019/10000/Determination_of_Serum_Infliximab_Concentration_by.17.aspx
https://journals.lww.com/jpgn/fulltext/2019/10000/Determination_of_Serum_Infliximab_Concentration_by.17.aspx
Autor:
Giuseppe Toffoli, Erika Cecchin, Giuliana Decorti, Alessandro Ventura, Marianna Lucafò, Matteo Bramuzzo, Angela Lora, Stefano Martelossi, Diego Favretto, Noelia Malusà, Raffaella Franca, Gabriele Stocco, Samuele Naviglio
Publikováno v:
Genes, Vol 10, Iss 4, p 277 (2019)
Genes
Volume 10
Issue 4
Genes
Volume 10
Issue 4
The contribution of candidate genetic variants involved in azathioprine biotransformation on azathioprine efficacy and pharmacokinetics in 111 young patients with inflammatory bowel disease was evaluated. Azathioprine doses, metabolites thioguanine-n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::affde16dde7c159f70a80239d43e10cf
http://hdl.handle.net/11368/2947085
http://hdl.handle.net/11368/2947085
Autor:
Pio D'Adamo, Antonio Murrone, Gabriele Stocco, Luigi Candussio, Giuliana Decorti, Gianluca Borotto, Noelia Malusà, Diego Favretto
We describe an interesting case of opioid unresponsive- ness, showing the importance of clinical history, inte- grated with pharmacokinetic and pharmacogenomic analysis, to shed light on mechanisms of abnormal response to opioid analgesics and provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4447494c1a2592838ea5482db9a3cde7
https://hdl.handle.net/11368/2919903
https://hdl.handle.net/11368/2919903
Autor:
Giuliana Decorti, Gabriele Stocco, Raffaella Franca, Marco Rabusin, Diego Favretto, Marilena Granzotto
Publikováno v:
Current Medicinal Chemistry. 24
Background: More than 85% of children affected by acute lymphoblastic leukemia (ALL) are successfully treated; however relapse remains a remarkable clinical concern, with 50-60% of relapsing patients facing a fatal outcome. Management of relapsed pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e84c237c5c66dcfb76f60a876c35b4b
https://doi.org/10.2174/0929867324666170113105733
https://doi.org/10.2174/0929867324666170113105733
Autor:
Erasmo Miele, Diego Favretto, Gabriele Stocco, Samuele Naviglio, Marina Aloi, Giuliana Decorti, Eva Cuzzoni, Massimo Martinelli, Arrigo Barabino, Alessandro Ventura, Stefano Martelossi, Claudio Romano, Raffaella Franca, Serena Arrigo, Daniela Knafelz
BACKGROUND: Early-onset inflammatory bowel disease (IBD) is generally aggressive, with a high probability of complications and need of surgery. Despite the introduction of highly effective biological drugs, treatment with azathioprine continues to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc6ede0a268b830cb95d32134154641
https://academic.oup.com/ibdjournal/article/23/4/628/4560763
https://academic.oup.com/ibdjournal/article/23/4/628/4560763
Autor:
Gabriele Stocco, Stefano Martelossi, Matthias Schwab, Ute Hofmann, Alessandro Ventura, Marco Pelin, Elena Genova, Diego Favretto, Andrea Taddio, Laura Fusco, Monzer Marisat, Marianna Lucafò, Giuliana Decorti
Aim To apply an innovative LC-MS/MS method to quantify thiopurine metabolites in human hepatocytes and to associate them to cytotoxicity. Methods Immortalized human hepatocytes (IHH cells) were treated for 48 and 96 h, with 1.4 × 10 −4 M azathiopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb15dad0be4181cccfe2072ba1455c9c
http://hdl.handle.net/11368/2909005
http://hdl.handle.net/11368/2909005
Autor:
Giuliana Decorti, Alberto Tommasini, Maria Grazia Valsecchi, Federico Verzegnassi, Paola Rebora, Raffaella Franca, Marco Rabusin, Giuseppe Basso, Diego Favretto, Emmanouil Athanasakis
Aim: In the AIEOP-BFM ALL (Associazione Italiana Ematologia Oncologia Pediatrica-Berlin Frankfurt Münster acute lymphoblastic leukemia) 2000 protocol, 70% of relapsed patients had favorable prognostic features and fell within less intensive polychem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7da2280fb86b3474af79117daf5459
http://hdl.handle.net/10281/53069
http://hdl.handle.net/10281/53069