Zobrazeno 1 - 10
of 339
pro vyhledávání: '"Diego F Calvisi"'
Autor:
Yu Qiao, Meng Xu, Junyan Tao, Li Che, Antonio Cigliano, Satdarshan P Monga, Diego F Calvisi, Xin Chen
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcinogenesis. β-catenin
Externí odkaz:
https://doaj.org/article/a9f9f490dd754639a4840db29d23e8fe
Autor:
Serena Mancarella, Isabella Gigante, Elena Pizzuto, Grazia Serino, Alberta Terzi, Francesco Dituri, Eugenio Maiorano, Leonardo Vincenti, Mario De Bellis, Francesco Ardito, Diego F. Calvisi, Gianluigi Giannelli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-15 (2024)
Abstract Background Cancer-associated fibroblasts (CAFs), mainly responsible for the desmoplastic reaction hallmark of intrahepatic Cholangiocarcinoma (iCCA), likely have a role in tumor aggressiveness and resistance to therapy, although the molecula
Externí odkaz:
https://doaj.org/article/f7201f2a93ed4fb2bd5f4cc907746a8b
Autor:
Antonio Cigliano, Isabella Gigante, Marina Serra, Gianpaolo Vidili, Maria M. Simile, Sara Steinmann, Francesco Urigo, Eleonora Cossu, Giovanni M. Pes, Maria P. Dore, Silvia Ribback, Egle P. Milia, Elena Pizzuto, Serena Mancarella, Li Che, Rosa M. Pascale, Gianluigi Giannelli, Matthias Evert, Xin Chen, Diego F. Calvisi
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-17 (2024)
Abstract Background Intrahepatic cholangiocarcinoma (iCCA) is a lethal primary liver tumor characterized by clinical aggressiveness, poor prognosis, and scarce therapeutic possibilities. Therefore, new treatments are urgently needed to render this di
Externí odkaz:
https://doaj.org/article/4358a36380b8455e977ec4053d406fe2
Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade.
Autor:
Jiaoyuan Jia, Yu Qiao, Maria G Pilo, Antonio Cigliano, Xianqiong Liu, Zixuan Shao, Diego F Calvisi, Xin Chen
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184068 (2017)
Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to inactivate the YAP protooncogene. In the present manuscript, we investigated the effect of Tankyrase inhibitors on the grow
Externí odkaz:
https://doaj.org/article/f1556e7aaf4d48f1a4300251203903df
Autor:
Shanshan Deng, Xinjun Lu, Xue Wang, Binyong Liang, Hongwei Xu, Doris Yang, Guofei Cui, Andrew Yonemura, Honor Paine, Yi Zhou, Yi Zhang, Maria Maddalena Simile, Francesco Urigo, Matthias Evert, Diego F. Calvisi, Benjamin L. Green, Xin Chen
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-11 (2024)
Abstract TBX3 behaves as a tumor suppressor or oncoprotein across cancer. However, TBX3 function remains undetermined in intrahepatic cholangiocarcinoma (iCCA), a deadly primary liver malignancy with few systemic treatment options. This study sought
Externí odkaz:
https://doaj.org/article/904e8d75b78a4941a72af5c5e04ec7b8
Autor:
Lei Li, Chunmei Wang, Diego F Calvisi, Matthias Evert, Maria G Pilo, Lijie Jiang, Mariia Yuneva, Xin Chen
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75104 (2013)
Increased de novo lipogenesis is one of the major metabolic events in cancer. In human hepatocellular carcinoma (HCC), de novo lipogenesis has been found to be increased and associated with the activation of AKT/mTOR signaling. In mice, overexpressio
Externí odkaz:
https://doaj.org/article/12cc23e57e6947cf8953f84c2e7320f8
Autor:
Lingling Fan, Chuanrui Xu, Chunmei Wang, Junyan Tao, Coral Ho, Lijie Jiang, Bing Gui, Shiang Huang, Matthias Evert, Diego F Calvisi, Xin Chen
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46472 (2012)
Bmi1 is a polycomb group transcriptional repressor and it has been implicated in regulating self-renewal and proliferation of many types of stem or progenitor cells. In addition, Bmi1 has been shown to function as an oncogene in multiple tumor types.
Externí odkaz:
https://doaj.org/article/393eb872a4454d05adc5f5071dfaea87
Autor:
Sophie Klemm, Katja Evert, Kirsten Utpatel, Alexandra Muggli, Maria M. Simile, Xin Chen, Matthias Evert, Diego F. Calvisi, Alexander Scheiter
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-16 (2023)
Abstract Background Upregulation of the mitogen-activated protein kinase (MAPK) cascade is common in hepatocellular carcinoma (HCC). Neuroblastoma RAS viral oncogene homolog (NRAS) is mutated in a small percentage of HCC and is hitherto considered in
Externí odkaz:
https://doaj.org/article/de2d353499314a8ba83c34a067ed7892
Autor:
Antonio Cigliano, Maria M. Simile, Gianpaolo Vidili, Giovanni M. Pes, Maria P. Dore, Francesco Urigo, Eleonora Cossu, Li Che, Claudio Feo, Sara M. Steinmann, Silvia Ribback, Rosa M. Pascale, Matthias Evert, Xin Chen, Diego F. Calvisi
Publikováno v:
Medicina, Vol 60, Iss 7, p 1160 (2024)
Background and Objectives: Aberrant upregulation of fatty acid synthase (FASN), catalyzing de novo synthesis of fatty acids, occurs in various tumor types, including human hepatocellular carcinoma (HCC). Although FASN oncogenic activity seems to resi
Externí odkaz:
https://doaj.org/article/9b831399f08b4b718d5859120af5fc63
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1624 (2024)
Hepatocellular carcinoma (HCC), the predominant primary liver tumor, remains one of the most lethal cancers worldwide, despite the advances in therapy in recent years. In addition to the traditional chemically and dietary-induced HCC models, a broad
Externí odkaz:
https://doaj.org/article/b14a71e1dcc342b2839dfb7a55032f4d