Zobrazeno 1 - 10 of 79 pro vyhledávání: '"Diego F, Alvarez"'
1
Akademický článek
Amyloid-β and caspase-1 are indicators of sepsis and organ injury
Autor: Amanda N. Tuckey, Arcole Brandon, Yasaman Eslaamizaad, Waqar Siddiqui, Talha Nawaz, Christopher Clarke, Erica Sutherland, Veronica Williams, Domenico Spadafora, Robert A. Barrington, Diego F. Alvarez, Madhuri S. Mulekar, Jon D. Simmons, Brian W. Fouty, Jonathon P. Audia
Publikováno v: ERJ Open Research, Vol 10, Iss 1 (2024)
Background Sepsis is a life-threatening condition that results from a dysregulated host response to infection, leading to organ dysfunction. Despite the prevalence and associated socioeconomic costs, treatment of sepsis remains limited to antibiotics
Externí odkaz: https://doaj.org/article/0c72f16b14924bceb1769addcd732091
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2
Akademický článek
Engineering Functional Vasculature in Decellularized Lungs Depends on Comprehensive Endothelial Cell Tropism
Autor: Ifeolu Akinnola, Daniel R. Rossi, Carolyn Meyer, Ashley Lindsey, Douglas R. Haase, Samuel Fogas, Michael J. Ehrhardt, Rachel E. Blue, Andrew. P. Price, Max Johnson, Diego F. Alvarez, Doris A. Taylor, Angela Panoskaltsis-Mortari
Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Tissue engineering using decellularized whole lungs as matrix scaffolds began as a promise for creating autologous transplantable lungs for patients with end-stage lung disease and can also be used to study strategies for lung regeneration. Vasculari
Externí odkaz: https://doaj.org/article/63e3e628c946430aa7925e44f4b51646
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3
Akademický článek
ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection
Autor: Kierra S. Hardy, Amanda N. Tuckey, Phoibe Renema, Mita Patel, Abu-Bakr Al-Mehdi, Domenico Spadafora, Cody A. Schlumpf, Robert A. Barrington, Mikhail F. Alexeyev, Troy Stevens, Jean-Francois Pittet, Brant M. Wagener, Jon D. Simmons, Diego F. Alvarez, Jonathon P. Audia
Publikováno v: Toxins, Vol 14, Iss 2, p 152 (2022)
The Gram-negative, opportunistic pathogen Pseudomonas aeruginosa utilizes a type III secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied exoenzymes, ExoU causes rapid cell damage and death. ExoU is a phosp
Externí odkaz: https://doaj.org/article/c9f84dac36d44282a31de0221c698954
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4
Akademický článek
Analysis of pulmonary vascular injury and repair during infection-induced pneumonia and acute respiratory distress syndrome
Autor: Ashley S. Lindsey, Lydia M. Sullivan, Nicole A. Housley, Anna Koloteva, Judy A. King, Jonathon P. Audia, Diego F. Alvarez
Publikováno v: Pulmonary Circulation, Vol 9 (2019)
Herein we describe lung vascular injury and repair using a rodent model of Pseudomonas aeruginosa pneumonia-induced acute respiratory distress syndrome (ARDS) during: 1) the exudative phase (48-hour survivors) and 2) the reparative/fibro-proliferativ
Externí odkaz: https://doaj.org/article/d51f1d9dcaed405abf5a75226289445a
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6
Integrative Toolkit to Analyze Cellular Signals: Forces, Motion, Morphology, and Fluorescence
Autor: Dhananjay T. Tambe, Troy Stevens, Diego F. Alvarez, Thomas Rich, Srinivas Palanki, Ajay P. Singh, Cassandra Chapman, Linn Ayers, Jessica Bell, Ningyong Xu, Sunita S. Paudel, Keith Battle, Alyson Nguyen
Publikováno v: Journal of Visualized Experiments.
Quantitative assessment of cellular forces and motion advanced considerably over the last four decades. These advancements provided the framework to examine insightful mechanical signaling processes in cell culture systems. However, the field current
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbbc1b62ed38f6963b37d4458b11757
https://doi.org/10.3791/63095-v
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7
Akademický článek
An Approach for Characterizing and Comparing Hyperspectral Microscopy Systems
Autor: Silas J. Leavesley, Thomas C. Rich, Diego F. Alvarez, Peter Favreau, Ashley S. Lindsey, Naga S. Annamdevula, Brenner Sweat
Publikováno v: Sensors, Vol 13, Iss 7, Pp 9267-9293 (2013)
Hyperspectral imaging and analysis approaches offer accurate detection and quantification of fluorescently-labeled proteins and cells in highly autofluorescent tissues. However, selecting optimum acquisition settings for hyperspectral imaging is ofte
Externí odkaz: https://doaj.org/article/fe884d7c2a94413c954c70129d4dba2f
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8
Unleashing shear: Role of intercellular traction and cellular moments in collective cell migration
Autor: Ningyong Xu, Alyson Nguyen, Dhananjay T. Tambe, Diego F. Alvarez, Troy Stevens, Shivani Ananthasekar, Neel G. Patel
Publikováno v: Biochemical and biophysical research communications
In the field of endothelial biology, the term “shear forces” is tied to the forces exerted by the flowing blood on the quiescent cells. But endothelial cells themselves also exert physical forces on their immediate and distant neighbors. Specific
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b91b23d073c5a77e0f93660708f52e
http://europepmc.org/articles/PMC6957749
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9
Mechanical signaling in a pulmonary microvascular endothelial cell monolayer
Autor: Troy Stevens, Diego F. Alvarez, Alyson Nguyen, Gnyata Patel, Dhananjay T. Tambe, Ningyong Xu, Jeffrey J. Fredberg
Publikováno v: Biochem Biophys Res Commun
The mechanical microenvironment of an endothelial cell includes a stable protein scaffold on the basal side, flowing blood on the apical side and contractile cells on the lateral sides. Interaction with the protein scaffold and flowing blood modulate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d60b511671c927899188df1f5e98e9
https://doi.org/10.1016/j.bbrc.2019.08.169
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