Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Diego E. Pafundo"'
1
Interneuron NMDA Receptor Ablation Induces Hippocampus-Prefrontal Cortex Functional Hypoconnectivity after Adolescence in a Mouse Model of Schizophrenia
Autor: Camila Lidia Zold, Juan E. Belforte, Diego E. Pafundo, Rodrigo Javier Alvarez
Publikováno v: J Neurosci
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Although the etiology of schizophrenia is still unknown, it is accepted to be a neurodevelopmental disorder that results from the interaction of genetic vulnerabilities and environmental insults. Although schizophrenia’s pathophysiology is still un
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f3bfb445ff8190f350838b1316699b
https://doi.org/10.1523/jneurosci.1897-19.2020
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2
A novel role for the lateral habenula in fear learning
Autor: Tomas E. Sachella, Marina R. Ihidoype, Christophe D. Proulx, Diego E. Pafundo, Jorge H. Medina, Pablo Mendez, Joaquin Piriz
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Neuropsychopharmacology
Fear is an extreme form of aversion that underlies pathological conditions such as panic or phobias. Fear conditioning (FC) is the best-understood model of fear learning. In FC the context and a cue are independently associated with a threatening unc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb3b14fcd8e42a82317a12ff0012a35d
http://hdl.handle.net/10261/274831
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3
Early NMDA Receptor Ablation in Interneurons Causes an Activity-Dependent E/I Imbalance in vivo in Prefrontal Cortex Pyramidal Neurons of a Mouse Model Useful for the Study of Schizophrenia
Autor: Carlos Alfredo Pretell Annan, Diego E. Pafundo, Juan E. Belforte, Nicolas M Fulginiti
Publikováno v: Schizophr Bull
Altered Excitatory/Inhibitory (E/I) balance of cortical synaptic inputs has been proposed as a central pathophysiological factor for psychiatric neurodevelopmental disorders, including schizophrenia (SZ). However, direct measurement of E/I synaptic b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1076d88718add68aed1ef5c8ba5c35ba
https://europepmc.org/articles/PMC8379555/
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4
Independence of Cued and Contextual Components of Fear Conditioning is Gated by the Lateral Habenula
Autor: Tomas E. Sachella, Marina R. Ihidoype, Christophe D. Proulx, Diego E. Pafundo, Jorge H. Medina, Pablo Mendez, Joaquin Piriz
Fear is an extreme form of aversion that, if inappropriately generalized, initiates pathological conditions such as panic or anxiety. Fear conditioning (FC) is the best understood model of fear learning. During FC two independent associations link th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d30b75efb48db1645fed105d87e6697
https://doi.org/10.1101/2020.07.12.197319
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5
Distinct Properties of Layer 3 Pyramidal Neurons from Prefrontal and Parietal Areas of the Monkey Neocortex
Autor: Olga Krimer, Guillermo Gonzalez-Burgos, Takeaki Miyamae, Holly Bazmi, Kenneth N. Fish, Yelena Gulchina, David A. Lewis, Diego E. Pafundo, Dominique Arion, Yosef Krimer, John F. Enwright
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
In primates, working memory function depends on activity in a distributed network of cortical areas that display different patterns of delay task-related activity. These differences are correlated with, and might depend on, distinctive properties of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f6c56f73cdb6931ae3a5b5105966f8
https://pubmed.ncbi.nlm.nih.gov/31341029
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6
Optostimulation of striatonigral terminals in substantia nigra induces dyskinesia that increases after L‐DOPA in a mouse model of Parkinson's disease
Autor: Ettel Keifman, Rosario Moratalla, Rodrigo Manuel Paz, Diego E. Pafundo, Irene Ruiz-DeDiego, Mario Gustavo Murer, Oscar Solís
Publikováno v: Br J Pharmacol
Digital.CSIC. Repositorio Institucional del CSIC
instname
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
BACKGROUND AND PURPOSE: L-DOPA-induced dyskinesia (LID) remains a major complication of L-DOPA therapy in Parkinson's disease. LID is believed to result from inhibition of substantia nigra reticulata (SNr) neurons by GABAergic striatal projection neu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795aa77bd4c01078333c94945e0470ff
Wiley Online Library
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7
Top-Down-Mediated Facilitation in the Visual Cortex Is Gated by Subcortical Neuromodulation
Autor: Ruilin Zhang, Sandra J. Kuhlman, Diego E. Pafundo, Mark A. Nicholas
Publikováno v: The Journal of Neuroscience. 36:2904-2914
Response properties in primary sensory cortices are highly dependent on behavioral state. For example, the nucleus basalis of the forebrain plays a critical role in enhancing response properties of excitatory neurons in primary visual cortex (V1) dur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612c7a3cec414a2d11364b22c5041e86
https://doi.org/10.1523/jneurosci.2909-15.2016
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8
Presynaptic Effects of N-Methyl-D-Aspartate Receptors Enhance Parvalbumin Cell–Mediated Inhibition of Pyramidal Cells in Mouse Prefrontal Cortex
Autor: David A. Lewis, Diego E. Pafundo, Guillermo Gonzalez-Burgos, Takeaki Miyamae
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Background: Testing hypotheses regarding the role of N-methyl-D-aspartate receptor (NMDAR) hypofunction in schizophrenia requires understanding the mechanisms of NMDAR regulation of prefrontal cortex (PFC) circuit function. NMDAR antagonists are thou
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65819eef6e833053db917f8be8ae337f
https://www.sciencedirect.com/science/article/pii/S0006322318300660
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9
Binocular deprivation induces both age-dependent and age-independent forms of plasticity in parvalbumin inhibitory neuron visual response properties
Autor: Diego E. Pafundo, Meredith N. Schmehl, Berquin D. Feese, Sandra J. Kuhlman
Publikováno v: Journal of neurophysiology. 119(2)
Activity of cortical inhibitory interneurons is rapidly reduced in response to monocular deprivation during the critical period for ocular dominance plasticity and in response to salient events encountered during learning. In the case of primary sens
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb182867bbc724788423e046b2f5506
https://pubmed.ncbi.nlm.nih.gov/29118195
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10
Functional Maturation of GABA Synapses During Postnatal Development of the Monkey Dorsolateral Prefrontal Cortex
Autor: Gil D. Hoftman, Allan R. Sampson, Kenneth N. Fish, David A. Lewis, Hiroki Yoshino, Mahjub Hammond, Takeaki Miyamae, Dibyadeep Datta, Guillermo Gonzalez-Burgos, Diego E. Pafundo, Yun Zhang, Diana C. Rotaru, G. Bard Ermentrout
Publikováno v: Cerebral Cortex. 25:4076-4093
Development of inhibition onto pyramidal cells may be crucial for the emergence of cortical network activity, including gamma oscillations. In primate dorsolateral prefrontal cortex (DLPFC), inhibitory synaptogenesis starts in utero and inhibitory sy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff01f00999d79a9d223c2ba354271848
https://doi.org/10.1093/cercor/bhu122
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