Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Diego Colombo"'
Autor:
Marco Nicola Iannone, Silvia Valtorta, Stefano Stucchi, Stefano Altomonte, Elia Anna Turolla, Elisa Vino, Paolo Rainone, Valentina Zecca, Alessia Lo Dico, Marco Maspero, Mariangela Figini, Matteo Bellone, Samuele Ciceri, Diego Colombo, Clizia Chinello, Lisa Pagani, Rosa Maria Moresco, Sergio Todde, Patrizia Ferraboschi
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-30 (2024)
Abstract Background In the last decade the development of new PSMA-ligand based radiopharmaceuticals for the imaging and therapy of prostate cancer has been a highly active and important area of research. The most promising derivative in terms of int
Externí odkaz:
https://doaj.org/article/a91d26a7184b4828a1736c39a7f40a60
The deubiquitinase USP8 regulates ovarian cancer cell response to cisplatin by suppressing apoptosis
Autor:
Cristina Corno, Padraig D’Arcy, Marina Bagnoli, Biagio Paolini, Matteo Costantino, Nives Carenini, Elisabetta Corna, Paola Alberti, Delia Mezzanzanica, Diego Colombo, Stig Linder, Noemi Arrighetti, Paola Perego
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The identification of therapeutic approaches to improve response to platinum-based therapies is an urgent need for ovarian carcinoma. Deubiquitinases are a large family of ubiquitin proteases implicated in a variety of cellular functions and may cont
Externí odkaz:
https://doaj.org/article/8fd3870d67564c868a440ef7473efdf5
Autor:
Samuele Ciceri, Diego Colombo, Enrico M. A. Fassi, Patrizia Ferraboschi, Giovanni Grazioso, Paride Grisenti, Marco Iannone, Carlo Castellano, Fiorella Meneghetti
Publikováno v:
Molecules, Vol 28, Iss 9, p 3861 (2023)
Elagolix sodium salt is the first marketed orally active non-peptide gonadotropin-releasing hormone receptor antagonist (GnRHR-ant) for the management of hormone dependent diseases, such as endometriosis and uterine fibroids. Despite its presence on
Externí odkaz:
https://doaj.org/article/86f314c55a4040219c41fea99a394d95
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Curcumin and related compounds are known for the large spectrum of activities. The chemical features of these compounds are important for their biological effects with a key role for the thiol-reactive α−β unsaturated carbonyl groups. Curcumin de
Externí odkaz:
https://doaj.org/article/da9db27f388d42a291b1b32762c6f3e4
Autor:
Matteo Mori, Stefania Villa, Samuele Ciceri, Diego Colombo, Patrizia Ferraboschi, Fiorella Meneghetti
Publikováno v:
Molecules, Vol 26, Iss 23, p 7082 (2021)
The elucidation of the structure of enzymes and their complexes with ligands continues to provide invaluable insights for the development of drugs against many diseases, including bacterial infections. After nearly three decades since the World Healt
Externí odkaz:
https://doaj.org/article/af77b5d349734418aaa45c7d3b7f3157
Autor:
Lisa Perruzza, Giorgio Gargari, Michele Proietti, Bruno Fosso, Anna Maria D’Erchia, Caterina Elisa Faliti, Tanja Rezzonico-Jost, Daniela Scribano, Laura Mauri, Diego Colombo, Giovanni Pellegrini, Annalisa Moregola, Catherine Mooser, Graziano Pesole, Mauro Nicoletti, Giuseppe Danilo Norata, Markus B. Geuking, Kathy D. McCoy, Simone Guglielmetti, Fabio Grassi
Publikováno v:
Cell Reports, Vol 18, Iss 11, Pp 2566-2575 (2017)
The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer’s patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to comme
Externí odkaz:
https://doaj.org/article/393daf25202c4bef9be01d20883d157a
Autor:
Matteo Mori, Ettore Gilardoni, Luca Regazzoni, Alessandro Pedretti, Diego Colombo, Gary Parkinson, Akira Asai, Fiorella Meneghetti, Stefania Villa, Arianna Gelain
Publikováno v:
Molecules, Vol 25, Iss 15, p 3509 (2020)
Signal transducer and activator of transcription 3 (STAT3) is a validated anticancer target due to the relationship between its constitutive activation and malignant tumors. Through a virtual screening approach on the STAT3-SH2 domain, 5,6-dimethyl-1
Externí odkaz:
https://doaj.org/article/77c2efb883124336931642529e63e37c
Publikováno v:
Journal on Interactive Systems, Vol 3, Iss 3 (2013)
Nenhum resumo disponível
Externí odkaz:
https://doaj.org/article/6bb5f89166a64c7294a18e8edef10c2e
Publikováno v:
Journal of Statistical Software, Vol 47, Iss 11 (2012)
The pcalg package for R can be used for the following two purposes: Causal structure learning and estimation of causal effects from observational data. In this document, we give a brief overview of the methodology, and demonstrate the package’s fun
Externí odkaz:
https://doaj.org/article/dc9f6f0f06f4490fa52ac4375ba60e0c
Publikováno v:
Current Medicinal Chemistry. 29:2566-2601
Platinum (Pt) drugs, including cisplatin, are widely used for the treatment of solid tumors. Despite the clinical success, side effects and occurrence of resistance represent major limitations to the use of clinically available Pt drugs. To overcome