Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Diego Bonetti"'
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110373- (2024)
Summary: Homologous recombination is initiated by the nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection is a two-step process. In the short-range step, the MRX (Mre11-Rad50-Xrs2) complex, together with Sae2, incise
Externí odkaz:
https://doaj.org/article/005a8cfcaad84c2196cb2a5f63050469
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Replicative senescence is an essential cellular process playing important physiological functions, but it is better known for its implications in aging, cancer, and other pathologies. One of the main triggers of replicative senescence is telomere sho
Externí odkaz:
https://doaj.org/article/2ff000631ee54863b1077de7d7a55039
Autor:
Diego Bonetti
Publikováno v:
Revista de Direito e Negócios Internacionais da Maritime Law Academy, Vol 2, Iss 1 (2022)
O Código Comercial (Lei n. 556, de 25 de junho de 1850) foi o primeiro diploma a regular o transporte no Direito Brasileiro, dispondo notadamente sobre o transporte marítimo. Por tempos o transporte foi regulado de forma superficial e casuística n
Externí odkaz:
https://doaj.org/article/3b2b3709c10f4b8b84570506bdc9a56a
Autor:
Erika Casari, Marco Gnugnoli, Carlo Rinaldi, Paolo Pizzul, Chiara Vittoria Colombo, Diego Bonetti, Maria Pia Longhese
Publikováno v:
Cells, Vol 11, Iss 20, p 3224 (2022)
Early work by Muller and McClintock discovered that the physical ends of linear chromosomes, named telomeres, possess an inherent ability to escape unwarranted fusions. Since then, extensive research has shown that this special feature relies on spec
Externí odkaz:
https://doaj.org/article/79fd461168b14762b39a5c02ee1060b7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the nascent RNA strongly binds the template DNA strand, l
Externí odkaz:
https://doaj.org/article/69ad709bd68c4433b77b95de79917b07
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108287- (2020)
Summary: Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs). DSB resection is a two-step process in which an initial short-range step is catalyzed by the Mre11-Rad50-Xrs2 (MRX) complex and
Externí odkaz:
https://doaj.org/article/8788204961c1485f8f14ff233146332e
Autor:
Erika Casari, Carlo Rinaldi, Antonio Marsella, Marco Gnugnoli, Chiara Vittoria Colombo, Diego Bonetti, Maria Pia Longhese
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
DNA double-strand breaks (DSBs) are highly cytotoxic lesions that must be repaired to ensure genomic stability and avoid cell death. The cellular response to DSBs is initiated by the evolutionarily conserved Mre11-Rad50-Xrs2/NBS1 (MRX/MRN) complex th
Externí odkaz:
https://doaj.org/article/02857ddb75954b589733cfeba7178062
Publikováno v:
Microbial Cell, Vol 3, Iss 8, Pp 329-337 (2016)
DNA double-strand breaks (DSBs) pose a serious threat to genome stability and cell survival. Cells possess mechanisms that recognize DSBs and promote their repair through either homologous recombination (HR) or non-homologous end joining (NHEJ). The
Externí odkaz:
https://doaj.org/article/7af6982a4cdf4ca6a8e4c3703a3c080e
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
DNA double-strand breaks (DSBs) are particularly hazardous lesions as their inappropriate repair can result in chromosome rearrangements, an important driving force of tumorigenesis. DSBs can be repaired by end joining mechanisms or by homologous rec
Externí odkaz:
https://doaj.org/article/0814656589a6475dbd46f10096ea1fe2
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1002024 (2011)
Telomere integrity in budding yeast depends on the CST (Cdc13-Stn1-Ten1) and shelterin-like (Rap1-Rif1-Rif2) complexes, which are thought to act independently from each other. Here we show that a specific functional interaction indeed exists among co
Externí odkaz:
https://doaj.org/article/ba50c7cb746349b3986cbdda4ba97566