Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Diego B, Diaz"'
Autor:
Joanne Tan, Armand B. Cognetta III, Diego B. Diaz, Kenneth M. Lum, Shinya Adachi, Soumajit Kundu, Benjamin F. Cravatt, Andrei K. Yudin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Heteroatom-rich organoboron compounds are promising modulators of enzyme activity. Here, the authors report a library of aminocyanoboronates as serine hydrolases inhibitors with the most potent compound showing in vivo and in vitro nanomolar activity
Externí odkaz:
https://doaj.org/article/2aff97f7effa472ca74895e649dd461a
Publikováno v:
RSC Chemical Biology. 3:739-747
Identification of turn motifs that are stabilized by intramolecular hydrogen bonds can be useful in describing the conformation of peptide systems. However, this approach is somewhat insufficient for cyclic peptides because peptide regions that are n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63578989f57b75a85762dfdf50cbda44
https://doi.org/10.1039/d2cb00016d
https://doi.org/10.1039/d2cb00016d
Autor:
Harjeet S. Soor, Diego B. Diaz, Ka Yi Tsui, Karina Calvopiña, Marcin Bielinski, Dean J. Tantillo, Christopher J. Schofield, Andrei K. Yudin
Publikováno v:
The Journal of Organic Chemistry. 87:94-102
Amidoboronic acid-containing peptidomimetics are an important class of scaffolds in chemistry and drug discovery. Despite increasing interest in boron-based enzyme inhibitors, constrained amidoboronic acids have received little attention due to the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc918521acf7aef794442f502df2b3a5
https://doi.org/10.1021/acs.joc.1c02015
https://doi.org/10.1021/acs.joc.1c02015
Publikováno v:
Angewandte Chemie International Edition. 60:16366-16371
Our ongoing search for underdeveloped functional group combinations has brought to light α-fluorinated aminoalkylboronic acids, a new class of molecules featuring the B-CF linkage. These compounds can now be generated from secondary amines and α-bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8942689fbbed8dbeef5e44bf1b49c4b5
https://doi.org/10.1002/anie.202104133
https://doi.org/10.1002/anie.202104133
Autor:
Diego B. Diaz, Timothy J. McTiernan, Andrei K. Yudin, Anastasia F. Bogdanchikova, Gabriel dos Passos Gomes, Yury Lebedev, Solomon D. Appavoo
Publikováno v:
Nature Chemistry. 13:218-225
Three-dimensional conformation is the primary determinant of molecular properties. The thermal energy available at room temperature typically equilibrates the accessible conformational states. Here, we introduce a method for isolating unique and prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb7722c800fd1156e596e8763b195c3
https://doi.org/10.1038/s41557-020-00620-y
https://doi.org/10.1038/s41557-020-00620-y
Publikováno v:
European Journal of Organic Chemistry. 2020:5029-5033
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5590915545b6f478e9653f17f140d871
https://doi.org/10.1002/ejoc.202000838
https://doi.org/10.1002/ejoc.202000838
Publikováno v:
Angewandte Chemie. 131:15292-15297
The synthesis and applications of carboxy-MIDA-boronate, a novel C1 building block, are described. This molecule is accessible via a ruthenium tetraoxide-mediated cleavage of commercially available ethynyl-MIDA-boronate. In the course of this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54492399415028d197fe979f807a062
https://doi.org/10.1002/ange.201907486
https://doi.org/10.1002/ange.201907486
Publikováno v:
Chemical Reviews. 119:9724-9752
The conformational analysis of macrocycles is a complex and challenging problem. There are many factors that contribute to this complexity. These include a large number of degrees of freedom, transannular interactions such as hydrogen bonds and hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0266ba23281f0cf640402ef4e68a6e45
https://doi.org/10.1021/acs.chemrev.8b00742
https://doi.org/10.1021/acs.chemrev.8b00742
Autor:
Joanne Tan, Julie J. Grouleff, Yulia Jitkova, Diego B. Diaz, Elizabeth C. Griffith, Wenjie Shao, Anastasia F. Bogdanchikova, Gennady Poda, Aaron D. Schimmer, Richard E. Lee, Andrei K. Yudin
Publikováno v:
Journal of Medicinal Chemistry. 62:6377-6390
Boronic acids have attracted the attention of synthetic and medicinal chemists due to boron's ability to modulate enzyme function. Recently, we demonstrated that boron-containing amphoteric building blocks facilitate the discovery of bioactive aminob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabd3e939fa5097a116b5bd4b830ec37
https://doi.org/10.1021/acs.jmedchem.9b00878
https://doi.org/10.1021/acs.jmedchem.9b00878
Publikováno v:
Chemical Communications. 55:10567-10570
Macrocyclization of linear peptide precursors using the Petasis borono-Mannich reaction affords a diverse range of macrocycles with an endocyclic amine. Analysis of the corresponding macrocyclic structures underscores that the hydrogen bond between a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938471ce508306b5957c8ef6f48fa64f
https://doi.org/10.1039/c9cc05934b
https://doi.org/10.1039/c9cc05934b