Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Diego Angosto"'
Autor:
Cristina Molina-López, Laura Hurtado-Navarro, Carlos J. García, Diego Angosto-Bazarra, Fernando Vallejo, Ana Tapia-Abellán, Joana R. Marques-Soares, Carmen Vargas, Segundo Bujan-Rivas, Francisco A. Tomás-Barberán, Juan I. Arostegui, Pablo Pelegrin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory condition resulting from monoallelic NLRP3 variants that facilitate IL-1β production. Although these are gain-of-function variants characterized by hypersensitivity to cel
Externí odkaz:
https://doaj.org/article/8fff75ee7c594dc3a2b4f18e746c4a0b
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
This review discusses emerging roles for the NLR family pyrin domain containing 6 receptor (NLRP6) in intestinal homeostasis, inflammation, cancer, the nervous system and liver disease.
Externí odkaz:
https://doaj.org/article/ac0c010038dc45f8b61db21a0b4e5dba
Autor:
Diego Angosto-Bazarra, Cristina Alarcón-Vila, Laura Hurtado-Navarro, María C. Baños, Jack Rivers-Auty, Pablo Pelegrín
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Gasdermins are ancient (>500million-years-ago) proteins, constituting a family of pore-forming proteins that allow the release of intracellular content including proinflammatory cytokines. Despite their importance in the immune re
Externí odkaz:
https://doaj.org/article/13fc3eb2f2734fffa31708fb4f36ce7d
Autor:
Julio García-Villalba, Laura Hurtado-Navarro, Alejandro Peñín-Franch, Cristina Molina-López, Laura Martínez-Alarcón, Diego Angosto-Bazarra, Alberto Baroja-Mazo, Pablo Pelegrin
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Inflammation is a tightly coordinated response against bacterial and viral infections, triggered by the production of pro-inflammatory cytokines. SARS-CoV-2 infection induces COVID-19 disease, characterized by an inflammatory response mediated throug
Externí odkaz:
https://doaj.org/article/da244b6cdac24de4acfc5751f80b9902
Autor:
Juan José Martínez-García, Helios Martínez-Banaclocha, Diego Angosto-Bazarra, Carlos de Torre-Minguela, Alberto Baroja-Mazo, Cristina Alarcón-Vila, Laura Martínez-Alarcón, Joaquín Amores-Iniesta, Fátima Martín-Sánchez, Giovanni A. Ercole, Carlos M. Martínez, Ada González-Lisorge, José Fernández-Pacheco, Piedad Martínez-Gil, Sahil Adriouch, Friedrich Koch-Nolte, Juan Luján, Francisco Acosta-Villegas, Pascual Parrilla, Carlos García-Palenciano, Pablo Pelegrin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Systemic sepsis is a potentially life-threatening illness and immunocompromised individuals are especially vulnerable. Here, using a cohort of patients with intra-abdominal origin sepsis, the authors show an important role for the NLRP3 inflammasome
Externí odkaz:
https://doaj.org/article/1ae90a92ab1d45b3b618703a201c9c3b
Autor:
Iva Hafner-Bratkovič, Petra Sušjan, Duško Lainšček, Ana Tapia-Abellán, Kosta Cerović, Lucija Kadunc, Diego Angosto-Bazarra, Pablo Pelegrin, Roman Jerala
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Activation of the NLRP3 inflammasome is associated with various diseases but its activation mechanism is not fully understood. Here, the authors determine the impact of different NLRP3 domains on sensing NLRP3 triggers, inflammasome assembly and regu
Externí odkaz:
https://doaj.org/article/1ef3edb735df4712b0a5732ea7fa1100
Autor:
Laura Hurtado-Navarro, Diego Angosto-Bazarra, Pablo Pelegrín, Alberto Baroja-Mazo, Santiago Cuevas
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 870 (2022)
Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial regulators of the inflammatory response through the activation of Caspase-
Externí odkaz:
https://doaj.org/article/443f81ab8a1e4205a2946d09eb043695
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108405- (2020)
Summary: The NLRP3 inflammasome, a critical component of the innate immune system, induces caspase-1 activation and interleukin (IL)-1β maturation in response to microbial infection and cellular damage. However, aberrant activation of the NLRP3 infl
Externí odkaz:
https://doaj.org/article/68a0edbb3a0c4f7795fab01050ed4557
Autor:
Diego Angosto-Bazarra, Cristina Molina-López, Alejandro Peñín-Franch, Laura Hurtado-Navarro, Pablo Pelegrín
Publikováno v:
Molecules, Vol 26, Iss 6, p 1704 (2021)
Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of multiple pathologies and diseases. The tight regulation of these immune sensors is necessary to control an optimal inflammatory response and recover organism h
Externí odkaz:
https://doaj.org/article/0f143f5032a545c59caf993897188552
Autor:
Sylwia D. Tyrkalska, Sergio Candel, Diego Angosto, Victoria Gómez-Abellán, Fátima Martín-Sánchez, Diana García-Moreno, Rubén Zapata-Pérez, Álvaro Sánchez-Ferrer, María P. Sepulcre, Pablo Pelegrín, Victoriano Mulero
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
The role of guanylate-binding proteins (GBPs) in innate immunity is increasingly recognized. Here the authors show that GBP4 activates inflammasome in zebrafish neutrophils, and that this process is critical for the clearance of Salmonellainfection v
Externí odkaz:
https://doaj.org/article/55bfda7fda31404dab8fdb2f0bb50c7f