Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Diego A. Pereira‐Martins"'
Autor:
Aleide S. Lima, Matheus F. Bezerra, Amanda Moreira-Aguiar, Isabel Weinhäuser, Bianca L. Santos, Raul M. Falcão, Maria L. Salustiano-Bandeira, Pedro L. Franca-Neto, Marinus M. Lima, Felipe Saldanha-Araujo, Juan L. Coelho-Silva, Diego A. Pereira-Martins, Marcos A. Bezerra, Antonio R. Lucena-Araujo
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 46, Iss 3, Pp 250-255 (2024)
Introduction: The aberrant expression of the inhibitor of DNA binding (ID1) gene has been frequently associated with the leukemogenesis and prognostication acute myeloid leukemia (AML), although its clinical importance has never been investigated in
Externí odkaz:
https://doaj.org/article/7c1873776b3546389a46d5d239e18b9a
Autor:
Maria L. Salustiano-Bandeira, Amanda Moreira-Aguiar, Diego A. Pereira-Martins, Juan L. Coelho-Silva, Isabel Weinhäuser, Pedro L. França-Neto, Aleide S. Lima, Ana S. Lima, Anemari R. Baccarin, Fernanda B. Silva, Manuela A. de Melo, Fernanda S. Niemann, Luciana Nardinelli, César A. Ortiz Rojas, Bruno K. Duarte, Aderson S. Araujo, Elisa A. Azevedo, Clarice N. Morais, Lorena L. Figueiredo-Pontes, Jan J. Schuringa, Gerwin Huls, Israel Bendit, Eduardo M. Rego, Sara T. Olalla Saad, Fabiola Traina, Marcos A. Bezerra, Antonio R. Lucena-Araujo
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/67ef150b7ee54451934361d769848375
Autor:
Tao Zhang, Glenn Marsman, Diego A. Pereira-Martins, Manfred Wuhrer, Gerwin A. Huls, Valerie R. Wiersma
Publikováno v:
Frontiers in Hematology, Vol 2 (2024)
Acute myeloid leukemia (AML) is a cancer of the myeloid lineage of blood cells, with an overall 5-year survival rate of 25%, mainly due to therapy-resistant relapses in > 50% of patients. The standard treatment for AML comprises cytarabine (AraC) wit
Externí odkaz:
https://doaj.org/article/b396b7f4a14d4694a136f34d0105e90b
Autor:
Isabel Weinhäuser, Diego A. Pereira-Martins, Jacobien R. Hilberink, Annet Brouwers-Vos, Eduardo M. Rego, Gerwin Huls, Jan Jacob Schuringa
Publikováno v:
Haematologica, Vol 109, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/a6032b8c6c124d25b2bc7e7184f7b3c6
Autor:
Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Inhibition of specific metabolic pathways often drives metabolic adaptation. Here, the authors show that FLT3-ITD + acute myeloid leukemia cells are OXPHOS-driven, and inhibition of complex II activity results in increased lactate influx to drive res
Externí odkaz:
https://doaj.org/article/c6190c32ad6545bcbde3640dce0f4ff7
Autor:
Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Roldán Cortés, Alan Cunningham, Maurien G. Pruis, Bauke de Boer, Fiona A. J. van den Heuvel, Marjan Geugien, Albertus T. J. Wierenga, Annet Z. Brouwers-Vos, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Acute myeloid leukemia (AML) is genetically a very heterogeneous disease. Here, Erdem et al. uncover heterogeneity in the metabolic landscape of AML and identify Pyruvate dehydrogenase kinase 1 (PDK1) as a targetable determinant of different metaboli
Externí odkaz:
https://doaj.org/article/0f8fe7450b4e4f25a3960cce038a7ad3
Autor:
Diego A. Pereira-Martins, Igor F. Domingos, Edis Belini-Junior, Juan L. Coelho-Silva, Isabel Weinhäuser, Aderson S. Araújo, Clarisse L. Lobo, Claudia R. Bonini-Domingos, Marcos A. Bezerra, Antonio R. Lucena-Araujo
Publikováno v:
Hematology, Transfusion and Cell Therapy, Vol 43, Iss 3, Pp 243-248 (2021)
Introduction: Sickle cell anemia (SCA) is a Mendelian disorder with a heterogeneous clinical course. The reasons for this phenotypic diversity are not entirely established, but it is known that high fetal hemoglobin levels lead to a milder course of
Externí odkaz:
https://doaj.org/article/b4f7b9e9364742d191c10f93c9d5a4c7
Autor:
Diego A. Pereira-Martins, Isabel Weinhäuser, Juan Luiz Coelho-Silva, Pedro L. França-Neto, Luciana Y. Almeida, Thiago M. Bianco, Cleide L. Silva, Rafael F. França, Fabiola Traina, Eduardo M. Rego, Jan Jacob Schuringa, Antonio R. Lucena-Araujo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Although the mixed lineage leukemia 5 (MLL5) gene has prognostic implications in acute promyelocyte leukemia (APL), the underlying mechanism remains to be elucidated. Here, we demonstrate the critical role exerted by MLL5 in APL regarding ce
Externí odkaz:
https://doaj.org/article/a952eae0379240d8894ca75104bea765
Autor:
Juan L. Coelho-Silva, Douglas R. A. Silveira, Diego A. Pereira-Martins, Cesar A. O. Rojas, Antonio R. Lucena-Araujo, Eduardo M. Rego, João A. Machado-Neto, Israel Bendit, Vanderson Rocha, Fabiola Traina
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Deregulated cellular energetics is formally incorporated as an emerging hallmark of cancer, however little is known about its processes in myelodysplastic syndromes (MDS). Using transcriptomic data of CD34+ cells from 159 MDS patients and 17
Externí odkaz:
https://doaj.org/article/8ba9e4b1885747c1968531cbed9acd10
Autor:
Luciana Yamamoto de Almeida, Diego A. Pereira-Martins, Isabel Weinhäuser, César Ortiz, Larissa A. Cândido, Ana Paula Lange, Nayara F. De Abreu, Sílvia E. S. Mendonza, Virgínia M. de Deus Wagatsuma, Mariane C. Do Nascimento, Helder H. Paiva, Raquel M. Alves-Paiva, Camila C. O. M. Bonaldo, Daniele C. Nascimento, José C. Alves-Filho, Priscila S. Scheucher, Ana Sílvia G. Lima, Jan Jacob Schuringa, Emanuele Ammantuna, Tiziana Ottone, Nelida I. Noguera, Cleide L. Araujo, Eduardo M. Rego
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
In approximately 15% of patients with acute myeloid leukemia (AML), total and phosphorylated EGFR proteins have been reported to be increased compared to healthy CD34+ samples. However, it is unclear if this subset of patients would benefit from EGFR
Externí odkaz:
https://doaj.org/article/7571ff921fee43699747c4b3cd44329e